3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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For detailed information about ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, go to the full flat file.

Word Map on EC 3.2.2.6

3.2.2.6

cadpr

ryanodine

aplysia

inositol

naadp

ectoenzyme

ca2+-mobilizing

californica

gdp-ribose

nadase

beta-nad+

urchin

diphosphoribose

calcium-mobilizing

8-br-cadpr

oxytocin

ca2+-releasing

anti-cd38

trisphosphate

8-bromo-cadpr

ca2+-induced

nad+-glycohydrolase

ngd+

ryanodine-sensitive

cd38-deficient

cadpr-mediated

cadpr-induced

Reaction

Synonyms

ADP-ribosyl cyclase, ADPR cyclase, bCD38, CD38, CD38/NAD+ glycohydrolase, NAD(P) nucleosidase, NAD(P)+ glycohydrolase, NAD(P)+-glycohydrolase, NAD(P)-glycohydrolase, NAD(P)ase, NAD+ glycohydrolase, NADase, nicotinamide adenine dinucleotide (phosphate) glycohydrolase, nicotinamide adenine dinucleotide (phosphate) nucleosidase, nucleosidase, nicotinamide adenine dinucleotide (phosphate), triphosphopyridine nucleotidase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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7500	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Crystallization (Commentary)
70	Disease/ Diagnostics
4	Expression
21	General Information
2	General Stability
16	IC50 Value
79	Inhibitors
12	kcat/KM [mM/s]
37	KM Value [mM]
11	Localization
4	Metals/Ions
10	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
25	Organism
4	Pathway
178	PDB ID
15	pH Optimum
1	pH Range
3	pH Stability
2	pI Value
3	Posttranslational Modification
26	Protein Variants
7	Purification (Commentary)
7	Reaction
1	Reaction Type
25	Reference
1	Renatured (Commentary)
28	Source Tissue
6	Specific Activity [micromol/min/mg]
5	Storage Stability
79	Substrates and Products (Substrate)
3	Subunits
33	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
12	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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NAD+ glycohydrolase (cyclic ADP-ribose-forming)

This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase.