3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
This is an abbreviated version!
For detailed information about ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, go to the full flat file.
Word Map on EC 3.2.2.6
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3.2.2.6
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cadpr
-
ryanodine
-
aplysia
-
inositol
-
naadp
-
ectoenzyme
-
ca2+-mobilizing
-
californica
-
gdp-ribose
-
nadase
-
beta-nad+
-
urchin
-
diphosphoribose
-
calcium-mobilizing
-
8-br-cadpr
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oxytocin
-
ca2+-releasing
-
anti-cd38
-
trisphosphate
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8-bromo-cadpr
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ca2+-induced
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nad+-glycohydrolase
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ngd+
-
ryanodine-sensitive
-
cd38-deficient
-
cadpr-mediated
-
cadpr-induced
- 3.2.2.6
-
cadpr
-
ryanodine
- aplysia
- inositol
-
naadp
-
ectoenzyme
-
ca2+-mobilizing
- californica
- gdp-ribose
- nadase
- beta-nad+
-
urchin
- diphosphoribose
-
calcium-mobilizing
-
8-br-cadpr
- oxytocin
-
ca2+-releasing
-
anti-cd38
-
trisphosphate
-
8-bromo-cadpr
-
ca2+-induced
- nad+-glycohydrolase
- ngd+
-
ryanodine-sensitive
-
cd38-deficient
-
cadpr-mediated
-
cadpr-induced
Reaction
Synonyms
ADP-ribosyl cyclase, ADPR cyclase, bCD38, CD38, CD38/NAD+ glycohydrolase, NAD(P) nucleosidase, NAD(P)+ glycohydrolase, NAD(P)+-glycohydrolase, NAD(P)-glycohydrolase, NAD(P)ase, NAD+ glycohydrolase, NADase, nicotinamide adenine dinucleotide (phosphate) glycohydrolase, nicotinamide adenine dinucleotide (phosphate) nucleosidase, nucleosidase, nicotinamide adenine dinucleotide (phosphate), triphosphopyridine nucleotidase
ECTree
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Reference
Reference on EC 3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
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Yamasaki, N.; Mori, I.; Takakuwa, M.
Purification and some properties of NAD(P)+ glycohydrolase from Saccharomyces cerevisiae
J. Ferment. Technol.
60
131-137
1982
Saccharomyces cerevisiae
-
Mather, I.H.; Knight, M.
A heat-stable nicotinamide-adenine dinucleotide glycohydrolase from Pseudomonas putida KB1. Partial purification and some properties of the enzyme and an inhibitory protein
Biochem. J.
129
141-152
1972
Pseudomonas putida KB1
Broeker, M.; Schindelmeiser, J.; Pape, H.
A nicotinamide adenine dinucleotide (phosphate) glycohydrolase [NAD(P)ase, EC 3.2.2.6] from Streptomyces griseus
FEMS Microbiol. Lett.
6
245-247
1979
Streptomyces griseus
-
Jorge, J.A.; Terenzi, H.F.
Carbon source regulation of nicotinamide adenine dinucleotide (phosphate) glycohydrolase in Neurospora crassa: induction and repression of enzyme synthesis
J. Gen. Microbiol.
130
1563-1568
1984
Neurospora crassa
Skala, H.; Lenoir, G.M.; Pichard, A.L.; Vuillaume, M.; Dreyfus, J.C.
Elevated NAD(P) glycohydrolase activity: a possible enzymatic marker for malignancy in Burkitt's lymphoma cells
Blood
60
912-917
1982
Homo sapiens
Artman, M.; Frankl, G.
Nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate splitting enzyme(s) of sheep and rabbit erythrocytes: their effect on the growth of Haemophilus
Can. J. Microbiol.
28
696-702
1982
Oryctolagus cuniculus, Ovis aries
Orsomando, G.; Polzonetti, V.; Natalini, P.
NAD(P)+-glycohydrolase from human spleen: a multicatalytic enzyme
Comp. Biochem. Physiol. B
126
89-98
2000
Homo sapiens
Berthelier, V.; Tixier, J.M.; Muller-Steffner, H.; Schuber, F.; Deterre, P.
Human CD38 is an authentic NAD(P)+ glycohydrolase
Biochem. J.
330
1383-1390
1998
Homo sapiens
-
Chini, E.N.; Dousa, T.P.
Enzymatic synthesis and degradation of nicotinate adenine dinucleotide phosphate (NAADP), a Ca2+-releasing agonist, in rat tissues
Biochem. Biophys. Res. Commun.
209
167-174
1995
Rattus norvegicus
Kellenberger, E.; Kuhn, I.; Schuber, F.; Muller-Steffner, H.
Flavonoids as inhibitors of human CD38
Bioorg. Med. Chem. Lett.
21
3939-3942
2011
Homo sapiens
Congleton, J.; Jiang, H.; Malavasi, F.; Lin, H.; Yen, A.
ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary
Exp. Cell Res.
317
910-919
2011
Homo sapiens
Lee, H.C.
Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling
Sci. China Life Sci.
54
699-711
2011
Mus musculus
Jiang, H.; Sherwood, R.; Zhang, S.; Zhu, X.; Liu, Q.; Graeff, R.; Kriksunov, I.A.; Lee, H.C.; Hao, Q.; Lin, H.
Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry
Anal. Biochem.
433
218-226
2013
Homo sapiens (P28907)
Kwong, A.; Chen, Z.; Zhang, H.; Leung, F.; Lam, C.; Ting, K.; Zhang, L.; Hao, Q.; Zhang, L.; Lee, H.
Catalysis-based inhibitors of the calcium signaling function of CD38
Biochemistry
51
555-564
2012
Rattus norvegicus, Homo sapiens (P28907), Mus musculus (P56528)
Kuhn, I.; Kellenberger, E.; Cakir-Kiefer, C.; Muller-Steffner, H.; Schuber, F.
Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues
Biochim. Biophys. Acta
1844
1317-1331
2014
Bos taurus (Q9TTF5), Bos taurus
Ma, Y.; Cao, W.; Wang, L.; Jiang, J.; Nie, H.; Wang, B.; Wei, X.; Ying, W.
Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels
Glia
62
943-955
2014
Mus musculus (P56528)
Shrimp, J.H.; Hu, J.; Dong, M.; Wang, B.S.; MacDonald, R.; Jiang, H.; Hao, Q.; Yen, A.; Lin, H.
Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe
J. Am. Chem. Soc.
136
5656-5663
2014
Homo sapiens (P28907)
Ikeda, T.; Takasawa, S.; Noguchi, N.; Nata, K.; Yamauchi, A.; Takahashi, I.; Yoshikawa, T.; Sugawara, A.; Yonekura, H.; Okamoto, H.
Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate
Mol. Cell. Biochem.
366
69-80
2012
Xenopus laevis (H7C831), Xenopus laevis
Coskun, O.; Nurten, R.
Purification of NAD+ glycohydrolase from human serum
Oncol. Lett.
6
227-231
2013
Homo sapiens (P28907)
Egea, P.F.; Muller-Steffner, H.; Kuhn, I.; Cakir-Kiefer, C.; Oppenheimer, N.J.; Stroud, R.M.; Kellenberger, E.; Schuber, F.
Insights into the mechanism of bovine CD38/NAD+ glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates
PLoS ONE
7
e34918
2012
Bos taurus (Q9TTF5), Bos taurus
Chini, C.; Hogan, K.A.; Warner, G.M.; Tarrago, M.G.; Peclat, T.R.; Tchkonia, T.; Kirkland, J.L.; Chini, E.
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Biochem. Biophys. Res. Commun.
513
486-493
2019
Homo sapiens (P28907)
Shu, B.; Feng, Y.; Gui, Y.; Lu, Q.; Wei, W.; Xue, X.; Sun, X.; He, W.; Yang, J.; Dai, C.
Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression
Cell. Signal.
42
249-258
2018
Mus musculus (P56528), Mus musculus
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