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3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

This is an abbreviated version!
For detailed information about ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, go to the full flat file.

Word Map on EC 3.2.2.6

Reaction

cyclic ADP-ribose
+
H2O
=
ADP-D-ribose

Synonyms

ADP-ribosyl cyclase, ADPR cyclase, bCD38, CD38, CD38/NAD+ glycohydrolase, NAD(P) nucleosidase, NAD(P)+ glycohydrolase, NAD(P)+-glycohydrolase, NAD(P)-glycohydrolase, NAD(P)ase, NAD+ glycohydrolase, NADase, nicotinamide adenine dinucleotide (phosphate) glycohydrolase, nicotinamide adenine dinucleotide (phosphate) nucleosidase, nucleosidase, nicotinamide adenine dinucleotide (phosphate), triphosphopyridine nucleotidase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Inhibitors

Inhibitors on EC 3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,N6-etheno NAD+
-
1-[2-azido-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]-3-carbamoylpyridinium
1-[5-O-[(benzyloxy)(hydroxy)phosphoryl]-2-deoxy-2-fluoro-L-erythro-pentofuranosyl]-3-carbamoylpyridinium
1-[5-O-[butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-D-threo-pentofuranosyl]-3-carbamoylpyridinium
2'-deoxy-2'-beta-D-fluoroarabinofuranoside NAD+
-
2'-deoxy-2'-beta-D-fluororibofuranoside NAD+
non-covalent complex of the inhibitor formed with enzyme mutant E218Q, PDB ID: 3ghh, and with wild-type enzyme, PDB ID: 3kou
3-aminopyridine
-
3-carbamoyl-1-[2-chloro-2-deoxy-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-thiophosphono-L-erythro-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[(hexyloxy)(hydroxy)phosphoryl]-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-5-O-[hydroxy(2-phenylethoxy)phosphoryl]-L-erythro-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-5-O-(diethoxyphosphoryl)-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[2-deoxy-5-O-[(ethenyloxy)(propoxy)phosphoryl]-2-fluoro-D-threo-pentofuranosyl]pyridinium
3-carbamoyl-1-[3-deoxy-3-fluoro-5-O-phosphono-L-threo-pentofuranosyl]pyridinium
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium
-
-
ADP-ribose
-
-
Ag+
-
50% inhibition of NADase and 300% activation of adenosine diphosphate cyclase; at 2 mM 50% inhibition of NADase activity and 300% activation of cADPR activity
arabinosyl 2'-fluoro-2'-deoxy-NAD
-
suicide substrate that inhibits CD38 ectoenzyme activity
arabinosyl-2'-fluoro-2'-deoxynicotinamide mononucleotide
Cr3+
-
inhibition of NADase and adenosine diphosphate cyclase
cyanidin
-
-
delphinidin
-
-
fisetinidin
-
-
HClO4
-
5%, 2°C, 10 min, 60% loss of the original activity
Isonicotinic acid hydrazide
-
kuromanin
-
-
luteolin
-
-
luteolinidin
-
-
malvidin
-
-
myricetin
-
-
nicotinamide
inhibition involves enzyme residue Trp181
Pb2+
-
complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase
pelargonidin
-
-
peonidin
-
-
petunidin
-
-
Pyridine
non-competitive inhibition of mutant E218A by pyridine
quercetagetin
-
-
quercetagetinidin
-
-
quercetin
-
-
robinetin
-
-
Sn2+
-
complete inhibition at 2 mM; inhibition of NADase and adenosine diphosphate cyclase
Zn2+
-
inhibition of NADase and adenosine diphosphate cyclase
additional information
-