3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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For detailed information about ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, go to the full flat file.

Reaction

Synonyms

ADP-ribosyl cyclase, ADPR cyclase, bCD38, CD38, CD38/NAD+ glycohydrolase, NAD(P) nucleosidase, NAD(P)+ glycohydrolase, NAD(P)+-glycohydrolase, NAD(P)-glycohydrolase, NAD(P)ase, NAD+ glycohydrolase, NADase, nicotinamide adenine dinucleotide (phosphate) glycohydrolase, nicotinamide adenine dinucleotide (phosphate) nucleosidase, nucleosidase, nicotinamide adenine dinucleotide (phosphate), triphosphopyridine nucleotidase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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7500	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	Crystallization (Commentary)
70	Disease/ Diagnostics
4	Expression
21	General Information
2	General Stability
16	IC50 Value
79	Inhibitors
12	kcat/KM [mM/s]
37	KM Value [mM]
11	Localization
4	Metals/Ions
10	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
25	Organism
4	Pathway
178	PDB ID
15	pH Optimum
1	pH Range
3	pH Stability
2	pI Value
3	Posttranslational Modification
26	Protein Variants
7	Purification (Commentary)
7	Reaction
1	Reaction Type
25	Reference
1	Renatured (Commentary)
28	Source Tissue
6	Specific Activity [micromol/min/mg]
5	Storage Stability
79	Substrates and Products (Substrate)
3	Subunits
33	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
12	Turnover Number [1/s]

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Cloned on EC 3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

gene cd38, eight exons, DNA and amino acid sequence determination and analysis, sequence comparison to the human enzyme, phylogenetic tree, expression in COS-7 cells

Xenopus laevis

H7C831

732501

recombinant expression of bovine CD38/NAD+ glycohydrolase truncated for the first 31 amino acids that encompass the transmembrane and short intracellular domains in Pichia pastoris. The construct comprises a DNA fragment encoding the ecto-domain in the expression plasmid pPICZaA in frame with the yeast alpha-factor secretion signal sequence under the transcriptional control of the AOX1 promoter and keeping its original stop codon

Bos taurus

Q9TTF5

732691

the soluble ecto-domain of human CD38 is expressed in Pichia pastoris

Homo sapiens

-

714434