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3.2.2.5: NAD+ glycohydrolase

This is an abbreviated version!
For detailed information about NAD+ glycohydrolase, go to the full flat file.

Word Map on EC 3.2.2.5

Reaction

NAD+
+
H2O
=
ADP-D-ribose
 +
nicotinamide
 +
H+

Synonyms

(Streptococcus pyogenes NAD+ glycohydrolase), AA-NADase, Acute lymphoblastic leukemia cells antigen CD38, ADP-ribosyl cyclase/NAD+-glycohydrolase, ADPRC, ADRC, Antigen BP3, beta-NAD+ glycohydrolase, beta-NAD+glycohydrolase, BP-3 alloantigen, cADPr hydrolase, CagL, CD157, CD157 antigen, CD38, CD38 homolog, CD38 like activity, CD38H, co-toxin NADase, Cyclic ADP-ribose hydrolase, diphosphopyridine nucleosidase, diphosphopyridine nucleotidase, DPN hydrolase, DPNase, ecto-NAD-glycohydrolase, HvnA, HvnB, I-19, Lymphocyte differentiation antigen CD38, NACE, NAD glycohydrolase, NAD hydrolase, NAD nucleosidase, NAD(+) nucleosidase, NAD+ catabolizing enzyme, NAD+ glycohydrolase, NAD+-glycohydrolase, NAD+glycohydrolase, NAD-glycohydrolase, NADase, Nga, nicotinamide adenine dinucleotide glycohydrolase, nicotinamide adenine dinucleotide nucleosidase, NIM-R5 antigen, PA0093, PAAR motif containing protein, PFL_6209, pNADase, SmNACE, sNADase, SPN, T10, Tse6

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.5 NAD+ glycohydrolase

Source Tissue

Source Tissue on EC 3.2.2.5 - NAD+ glycohydrolase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
lung epithelial cell line
Manually annotated by BRENDA team
-
TRAP(+) osteoclast formation is inhibitied by exogenous addition of enzyme or of ADPribose
Manually annotated by BRENDA team
-
enzyme level and ADP-ribosylation is significantly higher in patients and are correlated with tumour stage
Manually annotated by BRENDA team
-
leukemic cells, retinoic acid-treated
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
from bone marrow. Tumor necrosis factor alpha upregulates CD38. Induced CD38 expression enhances inflammatory gene expression by decreasing ERK1/2 phosphorylation and increasing NF kappaB activation. It negatively affects the expression of osteoclast markers. CD38 may reduce osteoclastogenesis and increase inflammatory gene induction by decreasing cellular histone deacetylase activity
Manually annotated by BRENDA team
-
CD38 is localized in or on sympathetic nerve terminals of this blood vessel
Manually annotated by BRENDA team
-
CD38 is localized in or on sympathetic nerve terminals of this blood vessel
Manually annotated by BRENDA team
-
sympathic nerve terminal of mesenteric artery or vein
Manually annotated by BRENDA team
-
bone marrow neutrophil
Manually annotated by BRENDA team
-
high enzyme levels in serum are associated with a poor prognosis in patients with colorectal cancer
Manually annotated by BRENDA team
-
enzyme is partially GPI-anchored, T-cell lacking ADP-ribosyltransferase activity
Manually annotated by BRENDA team
additional information