3.2.2.3: uridine nucleosidase
This is an abbreviated version!
For detailed information about uridine nucleosidase, go to the full flat file.
Word Map on EC 3.2.2.3
-
3.2.2.3
-
salvage
-
uracil
-
purine
-
protozoan
-
deaminase
-
crithidia
-
fasciculata
-
baker
-
orotate
-
ribonucleosides
-
schramm
-
vaginalis
-
trichomonas
-
glycosylase
-
pharmacology
- 3.2.2.3
-
salvage
- uracil
- purine
-
protozoan
- deaminase
-
crithidia
- fasciculata
-
baker
- orotate
- ribonucleosides
-
schramm
- vaginalis
-
trichomonas
- glycosylase
- pharmacology
Reaction
Synonyms
inosine-uridine nucleoside hydrolase, NSH1, nucleosidase, uridine, nucleoside hydrolase 1, PpNRH2, RihC, UNH, URH1, Urh1p, uridine hydrolase, uridine nucleoside ribohydrolase, Uridine ribohydrolase, uridine-cytidine N-ribohydrolase, uridine-preferring pyrimidine nucleoside hydrolase, uridine-ribohydrolase 1, uridine/cytidine hydrolase, ZmNRH2a, ZmNRH2b
ECTree
3.2.2.3 uridine nucleosidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.2.2.3 - uridine nucleosidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
isopentenyladenine riboside + H2O
D-ribose + N6-isopentenyladenine
-
-
-
-
?
cytidine + H2O
D-ribose + cytosine
-
3.9% of the activity with uridine
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
22% of the activity with uridine
-
-
?
inosine + H2O
D-ribose + hypoxanthine
9.3% of the activity with uridine
-
-
?
inosine + H2O
D-ribose + hypoxanthine
9.5% of the activity with uridine
-
-
?
nicotinamide riboside + H2O
nicotinamide + D-ribose
-
the uridine hydrolase is 100fold more active as a nicotinamide riboside hydrolase than as a uridine hydrolase
-
-
?
nicotinamide riboside + H2O
nicotinamide + D-ribose
-
the uridine hydrolase is 100fold more active as a nicotinamide riboside hydrolase than as a uridine hydrolase
-
-
?
nicotinic acid riboside + H2O
nicotinic acid + D-ribose
-
-
-
-
?
uridine + H2O
D-ribose + uracil
-
isoform NSH1 shows highest hydrolysis capacity for uridine
-
-
?
uridine + H2O
D-ribose + uracil
enzyme is important for recycling, via the salvage pathway, pyrimidine deoxy- and ribonucleosides into uracil required for the growth of strains lacking de novo pyrimidine synthesis pathway
-
-
?
uridine + H2O
uracil + D-ribose
-
-
-
-
?
xanthosine + H2O
D-ribose + xanthine
-
61% of the activity with uridine
-
-
?
additional information
?
-
the pure recombinant protein exhibits highest hydrolase activity for uridine, followed by inosine and adenosine
-
-
?
additional information
?
-
-
substrate specificity, overview. No activity with 2'-OH and 3'-OH deoxynucleosides. Nucleosides in which additional groups are added to the exocyclic N6 amino group also exhibit no activity. Nucleosides lacking the 5'-OH group or with the 2'-OH group in the arabino configuration exhibit greatly reduced activity. Purine nucleosides and pyrimidine nucleosides in which the N7 or N3 nitrogens respectively are replaced with carbon also have no activity
-
-
?
additional information
?
-
-
adenosine is a poor substrates, no activity with guanosine, trans-zeatin riboside, and cytokinin riboside, substrate specificity, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the metabolism of pyridine nucleotides
-
-
?
additional information
?
-
-
the enzyme is involved in cytidine metabolism
-
-
?
additional information
?
-
-
key enzyme of the pyrimidine salvage pathway, overview, enzyme is required for growth of mutants deficient in uridine kinase activity
-
-
?
additional information
?
-
physiological function, investigation of metabolic fluxes in several mutants impaired in the pyrimidine salvage pathway, regulation, overview
-
-
?
additional information
?
-
-
physiological function, investigation of metabolic fluxes in several mutants impaired in the pyrimidine salvage pathway, regulation, overview
-
-
?
additional information
?
-
-
inosine, adenosine, guanosine, and thymidine are poor substrates
-
-
?
additional information
?
-
substrate specificity, enzyme possesses no phosphorylase activity
-
-
?
additional information
?
-
-
substrate specificity, enzyme possesses no phosphorylase activity
-
-
?
additional information
?
-
-
no or almost no activity with guanosine, trans-zeatin riboside, and cytokinin riboside, substrate specificity, overview
-
-
?
additional information
?
-
no or almost no activity with guanosine, trans-zeatin riboside, and cytokinin riboside, substrate specificity, overview
-
-
?
additional information
?
-
-
poor activity with cytidine, guanosine, trans-zeatin riboside, and cytokinin riboside, substrate specificity, overview
-
-
?
