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3.2.2.27: uracil-DNA glycosylase

This is an abbreviated version!
For detailed information about uracil-DNA glycosylase, go to the full flat file.

Word Map on EC 3.2.2.27

Reaction

Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil =

Synonyms

5-formyluracil-DNA glycosylase, AFUDG, Afung protein, Blr0248, DNA N-glycosylase, dr0689, DR_0968, endonuclease VIII, family 1 uracil N-glycosylase, family 4 UDGa, family 4 uracil-DNA glycosylase, HMUDG, mismatch-specific uracil-DNA glycosylase, MjUDG, More, MtuNei1, MUG, Pa-UDG, PF1385, PfuUDG, single-strand selective monofunctional uracil-DNA glycosylase, single-strand selective uracil DNA glycosylase, single-strand-selective mono-functional uracil-DNA glycosylase, single-strand-selective monofunctional uracil DNA glycosylase, single-strand-selective monofunctional uracil-DNA glycosylase, single-stranded monofunctional uracil DNA N-glycosylase, SMUG1, SMUG1-like glycosylase, STK_22380, Ta0477, TD12-encoded protein, Thd1p, Thp1p, TMUDG, type 1 UDG, UDG, UDG1, UDGa, UdgB, UDGIV, UDGV, UL114, UL2, UNG, UNG-1, Ung-type uracil glycosylase, UNG1, UNG2, Unga, uracil DNA glycosylase, uracil DNA glycosylase 2, uracil DNA-glycosylase, uracil DNA-glycosylase 2, uracil-DNA glycosylase, uracil-DNA glycosylase 2, uracil-DNA glycosylase a, uracil-DNA N-glycosylase, uracil-N-glycosylase 2

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.27 uracil-DNA glycosylase

Temperature Range

Temperature Range on EC 3.2.2.27 - uracil-DNA glycosylase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 50
recombinant UDG, inactive above 50°C, temperature profile
20 - 50
fluorescence and activity measurements following incubation at different temperatures suggest the following model describing structure-activity relationships: at temperatures from 20 to 50°C the protein exists as a compact protein exhibiting low enzyme activity, whereas at temperatures above 50°C, the Afung conformation opens up, which is associated with the acquisition of high enzyme activity
37 - 65
the enzyme is more active at 65°C than at 37°C
55 - 85
-
high activity between 55 and 85°C
65 - 100
65°C: about 55% of maximal activity, 100°C: about 50% of maximal activity
additional information