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0.0046
5-hydroxymethyluracil-mismatched double-stranded DNA with U-A mismatch
pH 7.5, 30°C, recombinant hSMUG1
-
0.0027
5-hydroxymethyluracil-mismatched double-stranded DNA with U-G mismatch
pH 7.5, 30°C, recombinant hSMUG1
-
0.0038
5-hydroxymethyluracil-mismatched single-stranded DNA
pH 7.5, 30°C, recombinant hSMUG1
-
0.00017 - 0.00097
double stranded DNA containing G-U mismatch
-
0.0004 - 0.0028
dUMP DNA
-
0.0004 - 0.00277
uracil-containing calf thymus DNA
-
0.000054 - 0.00007
uracil-containing double-stranded DNA
-
0.000008 - 0.000011
uracil-containing single-stranded DNA
-
0.000015 - 0.256
uracil-mismatched double-stranded DNA
-
0.0007 - 0.004
uracil-mismatched double-stranded DNA with U-A mismatch
-
0.0000022 - 0.0013
uracil-mismatched double-stranded DNA with U-G mismatch
-
0.0005 - 0.0083
uracil-mismatched single-stranded DNA
-
additional information
additional information
-
0.00017
double stranded DNA containing G-U mismatch
mutant enzyme E41Q/G42D, at pH 7.6 and 60°C
-
0.00074
double stranded DNA containing G-U mismatch
mutant enzyme N89A, at pH 7.6 and 60°C
-
0.00076
double stranded DNA containing G-U mismatch
mutant enzyme H155S, at pH 7.6 and 60°C
-
0.00097
double stranded DNA containing G-U mismatch
wild type enzyme, at pH 7.6 and 60°C
-
0.0004
dUMP DNA
-
pH 7.5, recombinant wild-type enzyme
-
0.0011
dUMP DNA
pH 7.5, recombinant mutant V90R
-
0.0018
dUMP DNA
pH 7.5, recombinant mutant H194R
-
0.0028
dUMP DNA
pH 7.5, recombinant wild-type enzyme
-
0.0004
uracil-containing calf thymus DNA
-
mutant enzyme G183D/R302K, at pH 7.5 and 37°C
-
0.0005
uracil-containing calf thymus DNA
-
wild type enzyme, at pH 7.5 and 15°C
-
0.0006
uracil-containing calf thymus DNA
-
mutant enzyme G183D/R302K, at pH 7.5 and 22°C
-
0.00074
uracil-containing calf thymus DNA
-
mutant enzyme G183D, at pH 7.5 and 22°C
-
0.0008
uracil-containing calf thymus DNA
-
wild type enzyme, at pH 7.5 and 37°C
-
0.0008
uracil-containing calf thymus DNA
-
wild type enzyme, at pH 7.5 and 22°C
-
0.00083
uracil-containing calf thymus DNA
-
mutant enzyme G183D, at pH 7.5 and 37°C
-
0.001
uracil-containing calf thymus DNA
-
mutant enzyme G183D/R302K, at pH 7.5 and 15°C
-
0.00113
uracil-containing calf thymus DNA
-
mutant enzyme G183D, at pH 7.5 and 15°C
-
0.00157
uracil-containing calf thymus DNA
mutant enzyme D183G, at pH 7.5 and 37°C
-
0.0021
uracil-containing calf thymus DNA
wild type enzyme, at pH 7.5 and 37°C
-
0.0022
uracil-containing calf thymus DNA
wild type enzyme, at pH 7.5 and 15°C
-
0.00226
uracil-containing calf thymus DNA
mutant enzyme D183G, at pH 7.5 and 15°C
-
0.00238
uracil-containing calf thymus DNA
mutant enzyme D183G/K302R, at pH 7.5 and 15°C
-
0.0024
uracil-containing calf thymus DNA
wild type enzyme, at pH 7.5 and 22°C
-
0.00265
uracil-containing calf thymus DNA
mutant enzyme D183G/K302R, at pH 7.5 and 37°C
-
0.00276
uracil-containing calf thymus DNA
mutant enzyme D183G/K302R, at pH 7.5 and 22°C
-
0.00277
uracil-containing calf thymus DNA
mutant enzyme D183G, at pH 7.5 and 22°C
-
0.000054
uracil-containing double-stranded DNA
-
pH 7.5, 52°C, mutant enzyme K100A
-
0.00007
uracil-containing double-stranded DNA
-
pH 7.5, 52°C, wild-type enzyme
-
0.000008
uracil-containing single-stranded DNA
-
pH 7.5, 52°C, mutant enzyme K100A
-
0.000011
uracil-containing single-stranded DNA
-
pH 7.5, 52°C, wild-type enzyme
-
0.000015
uracil-mismatched double-stranded DNA
pH 7.0, 37°C, excision of a single uracil residue from PS-G, recombinant enzyme
-
0.00003
uracil-mismatched double-stranded DNA
pH 7.0, 37°C, excision of a single uracil residue from U-G, recombinant enzyme
-
0.0005
uracil-mismatched double-stranded DNA
pH 7.5, 37°C
-
0.0005
uracil-mismatched double-stranded DNA
pH 7.8, 70°C
-
0.0007
uracil-mismatched double-stranded DNA
pH 8.0, 37°C, recombinant enzyme
-
0.001
uracil-mismatched double-stranded DNA
pH 7.5, 37°C, excision of a single uracil residue from U-A, recombinant enzyme
-
0.001
uracil-mismatched double-stranded DNA
pH 7.5, 37°C, excision of a single uracil residue from U-G, recombinant enzyme
-
0.00134
uracil-mismatched double-stranded DNA
pH 7.5, 70°C
-
0.0014
uracil-mismatched double-stranded DNA
pH 7.5, 37°C, excision of a single uracil residue from U-T, recombinant enzyme
-
0.00151
uracil-mismatched double-stranded DNA
pH 7.5, 80°C
-
0.0016
uracil-mismatched double-stranded DNA
pH 7.5, 37°C, excision of a single uracil residue from U-C, recombinant enzyme
-
0.0017
uracil-mismatched double-stranded DNA
pH 7.5, 37°C, excision of a single uracil residue from PS-U, recombinant enzyme
-
0.003
uracil-mismatched double-stranded DNA
pH 7.5, 80°C, cell extract (wild-type enzyme)
-
0.0052
uracil-mismatched double-stranded DNA
pH 8.0, 37°C, recombinant wild-type enzyme
-
0.0087
uracil-mismatched double-stranded DNA
pH 7.5, 80°C, recombinant enzyme
-
0.009
uracil-mismatched double-stranded DNA
pH 8.0, 37°C, recombinant mutant A205S
-
0.148
uracil-mismatched double-stranded DNA
pH 8.0, 37°C, recombinant mutant H200Q
-
0.256
uracil-mismatched double-stranded DNA
pH 8.0, 37°C, recombinant mutant D77N
-
0.0007
uracil-mismatched double-stranded DNA with U-A mismatch
pH 7.5, 30°C, recombinant hUNG2
-
0.004
uracil-mismatched double-stranded DNA with U-A mismatch
pH 7.5, 30°C, recombinant hSMUG1
-
0.0000022
uracil-mismatched double-stranded DNA with U-G mismatch
pH 7.5, 37°C, wild-type enzyme
-
0.000035
uracil-mismatched double-stranded DNA with U-G mismatch
-
-
-
0.0004
uracil-mismatched double-stranded DNA with U-G mismatch
pH 7.5, 30°C, recombinant hUNG2
-
0.0013
uracil-mismatched double-stranded DNA with U-G mismatch
pH 7.5, 30°C, recombinant hSMUG1
-
0.0005
uracil-mismatched single-stranded DNA
-
-
-
0.0005
uracil-mismatched single-stranded DNA
pH 7.5, 37°C
-
0.0005
uracil-mismatched single-stranded DNA
pH 7.8, 95°C
-
0.0005
uracil-mismatched single-stranded DNA
-
wild type enzyme, at pH 7.5 and 15°C
-
0.000536
uracil-mismatched single-stranded DNA
pH 7.5, 95°C
-
0.0008
uracil-mismatched single-stranded DNA
-
wild type enzyme, at pH 7.4 and 37°C
-
0.001
uracil-mismatched single-stranded DNA
Q7WYV4
pH 7.5, 37°C, family 4 UDG
-
0.00109
uracil-mismatched single-stranded DNA
-
-
-
0.00157
uracil-mismatched single-stranded DNA
mutant enzyme G183G, at pH 7.4 and 37°C
-
0.0017
uracil-mismatched single-stranded DNA
pH 7.5, 30°C, recombinant hSMUG1
-
0.0021
uracil-mismatched single-stranded DNA
wild type enzyme, at pH 7.4 and 37°C
-
0.0022
uracil-mismatched single-stranded DNA
pH 7.5, 30°C, recombinant hUNG2
-
0.0022
uracil-mismatched single-stranded DNA
wild type enzyme, at pH 7.5 and 15°C
-
0.00265
uracil-mismatched single-stranded DNA
mutant enzyme G183G/K302R, at pH 7.4 and 37°C
-
0.004
uracil-mismatched single-stranded DNA
-
mutant enzyme G183D/R302K, at pH 7.4 and 37°C
-
0.0083
uracil-mismatched single-stranded DNA
-
mutant enzyme G183D, at pH 7.4 and 37°C
-
additional information
additional information
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kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
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kinetics
-
additional information
additional information
Q7WYV4
kinetic analysis
-
additional information
additional information
kinetics of mutant enzymes, overview
-
additional information
additional information
-
kinetics of mutant enzymes, overview
-
additional information
additional information
-
steady-state kinetics of wild-type and mutant enzymes
-
additional information
additional information
SMUG1 single-turnover kinetics using oligonucleotide substrates containing purine and pyrimidine analogs
-
additional information
additional information
-
SMUG1 single-turnover kinetics using oligonucleotide substrates containing purine and pyrimidine analogs
-
additional information
additional information
-
steady-state kinetics with several oligonucleitide substrate possessing U-A or U-G mispairs, overview
-
additional information
additional information
substrate specificity, kinetic analysis
-
additional information
additional information
-
substrate specificity, kinetic analysis
-
additional information
additional information
-
UNG2 kinetics
-
additional information
additional information
UNG2 kinetics
-
additional information
additional information
-
kinetic parameters for the opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1
-
additional information
additional information
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kinetics of MtuNei1 with diverse substrates, overview
-
additional information
additional information
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thermodynamics of UNG interactions with undamaged and damaged, e.g. 2'-deoxypseudouridine, substrates
-
additional information
additional information
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thermodynamics of UNG interactions with undamaged and damaged, e.g. 2'-deoxypseudouridine, substrates
-
additional information
additional information
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significantly different Km-values for the two substrates, with values of 70 nM for double-stranded DNA and 11 nM for single-stranded DNA
-