3.2.2.27: uracil-DNA glycosylase

This is an abbreviated version!
For detailed information about uracil-DNA glycosylase, go to the full flat file.

Reaction

Hydrolyses single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil =

Synonyms

5-formyluracil-DNA glycosylase, AFUDG, Afung protein, Blr0248, DNA N-glycosylase, dr0689, DR_0968, endonuclease VIII, family 1 uracil N-glycosylase, family 4 UDGa, family 4 uracil-DNA glycosylase, HMUDG, mismatch-specific uracil-DNA glycosylase, MjUDG, More, MtuNei1, MUG, Pa-UDG, PF1385, PfuUDG, single-strand selective monofunctional uracil-DNA glycosylase, single-strand selective uracil DNA glycosylase, single-strand-selective mono-functional uracil-DNA glycosylase, single-strand-selective monofunctional uracil DNA glycosylase, single-strand-selective monofunctional uracil-DNA glycosylase, single-stranded monofunctional uracil DNA N-glycosylase, SMUG1, SMUG1-like glycosylase, STK_22380, Ta0477, TD12-encoded protein, Thd1p, Thp1p, TMUDG, type 1 UDG, UDG, UDG1, UDGa, UdgB, UDGIV, UDGV, UL114, UL2, UNG, UNG-1, Ung-type uracil glycosylase, UNG1, UNG2, Unga, uracil DNA glycosylase, uracil DNA glycosylase 2, uracil DNA-glycosylase, uracil DNA-glycosylase 2, uracil-DNA glycosylase, uracil-DNA glycosylase 2, uracil-DNA glycosylase a, uracil-DNA N-glycosylase, uracil-N-glycosylase 2

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.27 uracil-DNA glycosylase

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Results	in table
9	Activating Compound
54789	AA Sequence
12	Application
1	CAS Registry Number
74	Cloned(Commentary)
1	Cofactor
24	Crystallization (Commentary)
425	Disease/ Diagnostics
3	Expression
35	General Information
4	General Stability
1	IC50 Value
66	Inhibitors
42	kcat/KM [mM/s]
4	Ki Value [mM]
90	KM Value [mM]
25	Localization
12	Metals/Ions
24	Molecular Weight [Da]
161	Natural Substrates/ Products (Substrates)
568	Organism
119	PDB ID
57	pH Optimum
9	pH Range
1	pH Stability
3	pI Value
2	Posttranslational Modification
127	Protein Variants
64	Purification (Commentary)
12	Reaction
152	Reference
1	Renatured (Commentary)
53	Source Tissue
27	Specific Activity [micromol/min/mg]
326	Substrates and Products (Substrate)
61	Subunits
288	Synonyms
1	Systematic Name
46	Temperature Optimum [°C]
10	Temperature Range [°C]
29	Temperature Stability [°C]
76	Turnover Number [1/s]

General Stability

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General Stability on EC 3.2.2.27 - uracil-DNA glycosylase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

HEPES pH 7.5, Tris pH 7.5, and imidazole pH 8.0 are the most stabilizing buffers

Homo sapiens

P13051

731683

HEPES pH 7.5, Tris pH 7.5, and imidazole pH 8.0 are the most stabilizing buffers for the enzyme

Homo sapiens

P13051

750352

Tris pH 7.5 and 8.0, and HEPES pH 7.5 are the most stabilizing buffers for the enzyme

Gadus morhua

-

750352

Tris pH 7.5 and 8.0, and HEPES pH 7.5 are the most stabilizing buffers,

Gadus morhua

-

731683