3.2.2.25: N-methyl nucleosidase

This is an abbreviated version!
For detailed information about N-methyl nucleosidase, go to the full flat file.

Reaction

Synonyms

7-methyl-N9-nucleoside hydrolase, N-MeNase, NMT1, NMT2

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.25 N-methyl nucleosidase

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Results	in table
1	CAS Registry Number
8	Inhibitors
1	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
3	Organism
6	Pathway
2	pH Optimum
1	pH Stability
1	Purification (Commentary)
1	Reaction
3	Reference
3	Source Tissue
2	Specific Activity [micromol/min/mg]
15	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.2.2.25 - N-methyl nucleosidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1-methyladenosine + H2O

1-methyladenine + D-ribose

Camellia sinensis

-

22% of the activity with 7-methylxanthosine, substrate as 7-methyladenosine perchlorate

137101

-

-

ir

1-methylinosine + H2O

1-methylhypoxanthine + D-ribose

Camellia sinensis

-

9% of the activity with 7-methylxanthosine

137101

-

-

ir

1-methylxanthosine + H2O

1-methylxanthine + D-ribose

Camellia sinensis

-

12% of the activity with 7-methylxanthosine

137101

-

-

ir

3-methyladenosine + H2O

3-methyladenine + D-ribose

Camellia sinensis

-

178% of the activity with 7-methylxanthosine, substrate as 3-methyladenosine p-toluenesulfonate

137101

-

-

ir

3-methylguanosine + H2O

3-methylguanine + D-ribose

Camellia sinensis

-

38% of the activity with 7-methylxanthosine

137101

-

-

ir

3-methylinosine + H2O

3-methylhypoxanthine + D-ribose

Camellia sinensis

-

128% of the activity with 7-methylxanthosine

137101

-

-

ir

3-methylxanthosine + H2O

3-methylxanthine + D-ribose

Camellia sinensis

-

198% of the activity with 7-methylxanthosine

137101

-

-

ir

7-methyladenosine + H2O

7-methyladenine + D-ribose

Camellia sinensis

-

13% of the activity with 7-methylxanthosine

137101

-

-

ir

7-methylguanosine + H2O

7-methylguanine + D-ribose

Camellia sinensis

-

189% of the activity with 7-methylxanthosine

137101

-

-

ir

7-methylinosine + H2O

7-methylhypoxanthine + D-ribose

Camellia sinensis

-

121% of the activity with 7-methylxanthosine

137101

-

-

ir

7-methylxanthosine + H2O

7-methylxanthine + D-ribose

4 entries

additional information

?

-

Camellia sinensis

-

substrate specificity, overview, no activity with 1-methylguanosine and guanosine, poor activity with inosine and adenosine

137101

-

-

?

7-methylxanthosine + H2O

7-methylxanthine + D-ribose

Camellia sinensis

-

second step in caffeine biosynthesis, pathway overview

137101

-

-

ir

7-methylxanthosine + H2O

7-methylxanthine + D-ribose

Camellia sinensis

-

the reverse reaction is catalyzed by a nucleoside phosphorylase using ribose-1-phosphate, overview

137101

-

-

ir

7-methylxanthosine + H2O

7-methylxanthine + D-ribose

Coffea arabica

-

-

670507

-

-

?

7-methylxanthosine + H2O

7-methylxanthine + D-ribose

Coffea arabica

-

step in caffeine biosynthesis, feeding experiments, overview

670507

-

-

?