3.2.2.24: ADP-ribosyl-[dinitrogen reductase] hydrolase
This is an abbreviated version!
For detailed information about ADP-ribosyl-[dinitrogen reductase] hydrolase, go to the full flat file.
Word Map on EC 3.2.2.24
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3.2.2.24
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adp-ribosylation
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rhodospirillum
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rubrum
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adp-ribosyltransferase
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azospirillum
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brasilense
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adp-ribose
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pii
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macrod2
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mono-adp-ribosylation
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dratg
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fe-protein
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lipoferum
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glnz
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macrodomains
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switch-off
- 3.2.2.24
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adp-ribosylation
- rhodospirillum
- rubrum
- adp-ribosyltransferase
- azospirillum
- brasilense
- adp-ribose
- pii
- macrod2
-
mono-adp-ribosylation
-
dratg
- fe-protein
- lipoferum
- glnz
-
macrodomains
-
switch-off
Reaction
Synonyms
ADP-ribosyl glycohydrolase, ADP-ribosylglycohydrolase, ADP-ribosylhydrolase, azoferredoxin-activating enzymes, dinitrogenase reductase activating glycohydrolase, dinitrogenase reductase ADP-glycohydrolase, dinitrogenase reductase glycohydrolase, dinitrogenase reductase-activating glycohydrolase, DRAG, glycosidase, azoferredoxin, mono-ADP-ribosylhydrolase, More
ECTree
3.2.2.24 ADP-ribosyl-[dinitrogen reductase] hydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.2.2.24 - ADP-ribosyl-[dinitrogen reductase] hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
-
enzyme is sensitive to the redox-state of the (Fe4S4) cluster of substrate protein, having less than 2% of activity with oxidized Fe protein compared to reduced Fe protein
-
-
?
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex + H2O
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
ADP-D-ribosyl-[dinitrogen reductase]
ADP-D-ribose + [dinitrogen reductase]
-
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
Nalpha-dansyl-Nomega-(1,N6-etheno-ADP-ribosyl)-arginine methyl ester
ADP-ribose + Nalpha-dansyl-Nomega-(1,N6-ethyl)-arginine methyl ester
-
-
-
-
?
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex + H2O
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
-
-
-
-
?
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex + H2O
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
-
ADP-ribosylation of initrogenase reductase (NifH) occurs in response to addition of ammonium to the extracellular medium and is mediated by dinitrogenase reductase ADP-ribosyltransferase (DraT) and reversed by dinitrogenase reductase glycohydrolase (DraG). The PII protein GlnZ is implicated in regulation DraG. DraG binds to both the uridylylated and deuridylylated forms of GlnZ
-
-
?
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex + H2O
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
-
-
-
-
?
ADP-D-ribosyl-(dinitrogen reductase) component of nitrogenase complex + H2O
ADP-ribose + (dinitrogen reductase) component of nitrogenase complex
-
nitrogenase activity in Rhodospirillum rubrum is post-translationally regulated by DRAG (dinitrogenase reductase glycohydrolase) and DRAT (dinitrogenase reductase ADP-ribosylation transferase). When a sudden increase in fixed nitrogen concentration or energy depletion is sensed by the cells, DRAG is inactivated and DRAT activated
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
i.e. component II or Fe-protein, one of the two identical subunits of dinitrogen reductase
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
i.e. component II or Fe-protein, one of the two identical subunits of dinitrogen reductase
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-D-ribosyl-[dinitrogen reductase] component of nitrogenase complex
ADPribose + [dinitrogen reductase] component of nitrogenase complex
-
-
-
?
ADP-ribosyl-[dinitrogen reductase] + H2O
ADP-ribose + [dinitrogen reductase]
-
-
-
?
ADP-ribosyl-[dinitrogen reductase] + H2O
ADP-ribose + [dinitrogen reductase]
substrate is the Azospirillum brasilense dinitrogenase, DraG on Arg101, modeling of the binding of the substrate ADP-ribosyl moiety to DraG, active site structure, overview
-
-
?
ADP-ribosyl-[dinitrogen reductase] + H2O
ADP-ribose + [dinitrogen reductase]
-
-
-
?
ADP-ribosyl-[dinitrogen reductase] + H2O
ADP-ribose + [dinitrogen reductase]
DraG removes ADP-ribose upon exposure of the bacteria to light or depletion of the nitrogen source added, regenerating the arginine guanidino group and activating the dinitrogenase reductase dimer
-
-
?
ADP-ribosylated Fe-protein
ADP-D-ribose + Fe-protein
-
-
-
?
additional information
?
-
the enzyme acts specifically towards a mono-ADP-ribosylated substrate, structure-function relationship, overview
-
-
?
additional information
?
-
-
the enzyme acts specifically towards a mono-ADP-ribosylated substrate, structure-function relationship, overview
-
-
?
additional information
?
-
-
no substrate: dinitrogen reductase from Anabaena variabilis
-
-
?
additional information
?
-
-
activity depends on oxidation state of Fe protein, with reduced Fe protein about 2% of activity compared to oxidized substrate
-
-
?
additional information
?
-
DraG is capable of auto ADP-ribosylation when in excess of ADP-ribose, this reaction can function as an autoregulatory mechanism in vivo
-
-
?
additional information
?
-
-
DraG is capable of auto ADP-ribosylation when in excess of ADP-ribose, this reaction can function as an autoregulatory mechanism in vivo
-
-
?
