3.2.2.21: DNA-3-methyladenine glycosylase II
This is an abbreviated version!
For detailed information about DNA-3-methyladenine glycosylase II, go to the full flat file.
Word Map on EC 3.2.2.21
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3.2.2.21
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glycosylases
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endonuclease
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8-oxoguanine
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strand
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guanine
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thymine
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mismatch
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abasic
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pyrimidine
-
uracil
-
duplex
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8-oxog
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excises
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cytosine
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alkyladenine
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mispairs
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mutyh
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7,8-dihydro-8-oxoguanine
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formamidopyrimidine
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hypoxanthine
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7-methylguanine
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ape1
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5-methylcytosine
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1,n6-ethenoadenine
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undamaged
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8-hydroxyguanine
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8-oxo-7,8-dihydroguanine
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formamidopyrimidine-dna
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nucleobase
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transversions
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apurinic
-
uracil-dna
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n-glycosidic
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ser326cys
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etheno
-
mutyh-associated
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unrepaired
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mismatch-specific
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8-oxo-7,8-dihydro-2'-deoxyguanosine
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base-excision
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5-hydroxymethyluracil
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apyrimidinic
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8-oxoguanine-dna
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premutagenic
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alkylation-induced
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ap-endonuclease
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thymine-dna
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medicine
-
miscoding
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extrahelical
-
methylmethane
- 3.2.2.21
- glycosylases
- endonuclease
- 8-oxoguanine
- strand
- guanine
- thymine
- mismatch
-
abasic
- pyrimidine
- uracil
- duplex
-
8-oxog
-
excises
- cytosine
-
alkyladenine
- mispairs
-
mutyh
- 7,8-dihydro-8-oxoguanine
- formamidopyrimidine
- hypoxanthine
- 7-methylguanine
- ape1
- 5-methylcytosine
- 1,n6-ethenoadenine
-
undamaged
- 8-hydroxyguanine
- 8-oxo-7,8-dihydroguanine
-
formamidopyrimidine-dna
-
nucleobase
-
transversions
-
apurinic
-
uracil-dna
-
n-glycosidic
-
ser326cys
-
etheno
-
mutyh-associated
-
unrepaired
-
mismatch-specific
-
8-oxo-7,8-dihydro-2'-deoxyguanosine
-
base-excision
- 5-hydroxymethyluracil
-
apyrimidinic
-
8-oxoguanine-dna
-
premutagenic
-
alkylation-induced
- ap-endonuclease
-
thymine-dna
- medicine
-
miscoding
-
extrahelical
-
methylmethane
Reaction
Synonyms
3-methyladenine DANN glycosylase II, 3-methyladenine DNA glycosylase II, 3-methyladenine-DNA glycosidase II, 3-methyladenine-DNA glycosylase II, AAG, ALK, AlkA, AlkA protein, AlkA1, AlkA2, AlkD, alkylpurine-DNA-N-glycosylase, ANPG, deoxyribonucleate 3-methyladenine glycosidase II, DNA glycosylase, DNA-3-methyladenine glycosidase II, helix-hairpin-helix DNA glycosylase, m3A DNA glycosylase II, MAG, Mag1 protein, MPG, N-methylpurine-DNA glycosylase, TagII
ECTree
3.2.2.21 DNA-3-methyladenine glycosylase IIAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.2.2.21 - DNA-3-methyladenine glycosylase II
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + DNA
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
alkylated DNA + H2O
7-methyladenine + 7-methylguanine + 3-methyladenine + 3-methylguanine + purine + 6-chloropurine + xanthine + DNA
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7-methylguanine is cleaved the most quickly
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
646845, 646846, 646847, 646851, 646872, 646876, 646877, 646878, 646880, 646885, 646888, 646891, 646892
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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induced by cell exposure to sublethal doses of alkylating agents, important role in the excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
short-patch base excision repair pathway, repair of alkylation and oxidative DNA damage
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
cellular repair of alkylated DNA base modifications
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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binds mismatch base-pairs in DNA
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
alkylated DNA + H2O
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
-
-
-
?
additional information
?
-
-
AlkD is involved exclusively in the repair of alkylation damage
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-
?
additional information
?
-
the enzyme isoform AlkA2 possesses no activity towards 1,N6-ethenoadenine and hypoxanthine in alkylated DNA
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-
?
additional information
?
-
-
the enzyme isoform AlkA2 possesses no activity towards 1,N6-ethenoadenine and hypoxanthine in alkylated DNA
-
-
?
additional information
?
-
-
the enzyme is induced in response to DNA alkylation, and it protects cells from alkylated nucleobases by catalyzing their excision
-
-
?
