3.2.2.21: DNA-3-methyladenine glycosylase II

This is an abbreviated version!
For detailed information about DNA-3-methyladenine glycosylase II, go to the full flat file.

Word Map on EC 3.2.2.21

3.2.2.21

glycosylases

endonuclease

8-oxoguanine

strand

guanine

thymine

mismatch

abasic

pyrimidine

uracil

duplex

8-oxog

excises

cytosine

alkyladenine

mispairs

mutyh

7,8-dihydro-8-oxoguanine

formamidopyrimidine

hypoxanthine

7-methylguanine

ape1

5-methylcytosine

1,n6-ethenoadenine

undamaged

8-hydroxyguanine

8-oxo-7,8-dihydroguanine

formamidopyrimidine-dna

nucleobase

transversions

apurinic

uracil-dna

n-glycosidic

ser326cys

etheno

mutyh-associated

unrepaired

mismatch-specific

8-oxo-7,8-dihydro-2'-deoxyguanosine

base-excision

5-hydroxymethyluracil

apyrimidinic

8-oxoguanine-dna

premutagenic

alkylation-induced

ap-endonuclease

thymine-dna

medicine

miscoding

extrahelical

methylmethane

Reaction

Synonyms

3-methyladenine DANN glycosylase II, 3-methyladenine DNA glycosylase II, 3-methyladenine-DNA glycosidase II, 3-methyladenine-DNA glycosylase II, AAG, ALK, AlkA, AlkA protein, AlkA1, AlkA2, AlkD, alkylpurine-DNA-N-glycosylase, ANPG, deoxyribonucleate 3-methyladenine glycosidase II, DNA glycosylase, DNA-3-methyladenine glycosidase II, helix-hairpin-helix DNA glycosylase, m3A DNA glycosylase II, MAG, Mag1 protein, MPG, N-methylpurine-DNA glycosylase, TagII

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.21 DNA-3-methyladenine glycosylase II

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Results	in table
7	Activating Compound
5198	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
1	Cofactor
13	Crystallization (Commentary)
416	Disease/ Diagnostics
2	General Information
1	General Stability
23	Inhibitors
1	kcat/KM [mM/s]
17	KM Value [mM]
1	Localization
13	Metals/Ions
11	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
80	Organism
58	PDB ID
4	pH Optimum
2	pI Value
15	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
65	Reference
1	Renatured (Commentary)
15	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
124	Substrates and Products (Substrate)
1	Subunits
54	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.2.2.21 - DNA-3-methyladenine glycosylase II

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2'-deoxy-2'-fluoro-7-methylguanosine

Escherichia coli

P04395

715554

abasic-containing DNA

potent inhibitor

apurinic-DNA

CaCl2

DNA containing 1-azaribose

Double-stranded DNA

Mg2+

significant inhibition depending on its concentration, but independent of substrate type. Mg2+ at high but physiologic concentrations decreases the amount of active enzyme. Inhibition affects the Km value, but not Vmax, and is due to inhibition in substrate binding and can be reversed by EDTA. At low concentration, Mg2+ stimulates enzyme activity with substrate hypoxanthine, but not with ethenoadenine

N-ethylmaleimide

NaCl

Ni2+

0.001 mM

p-hydroxymercuribenzoate

Archaeoglobus fulgidus

646888

p-mercuribenzoate

Micrococcus luteus

646851

Pyrrolidine-containing oligonucleotide

Escherichia coli

646874

ZnSO4

Archaeoglobus fulgidus

2 mM, enzyme activity 23%

646888

additional information

6 entries