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3.2.2.2: inosine nucleosidase

This is an abbreviated version!
For detailed information about inosine nucleosidase, go to the full flat file.

Word Map on EC 3.2.2.2

Reaction

Inosine
+
H2O
=
D-ribose
 +
hypoxanthine

Synonyms

guanosine-inosine-preferring nucleoside N-ribohydrolase, inosinase, inosine hydrolase, inosine-adenosine-guanosine nucleoside hydrolase, inosine-guanosine nucleosidase, NSH2, nucleosidase, inosine, purine-specific nucleoside hydrolase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.2 inosine nucleosidase

Inhibitors

Inhibitors on EC 3.2.2.2 - inosine nucleosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2'-deoxyguanosine
-
competitive
2'-methylguanosine
-
competitive
6-mercaptopurine riboside
-
-
adenine
adenosine
-
competitive
ATP
-
binds to I1- and I2-site, noncompetitive inhibition, ligand exclusion model
Co2+
-
24.2% residual activity at 0.1 M using inosine as substrate, 25.8% residual activity at 0.1 M using guanosine as substrate, 33.3% residual activity at 0.1 M using adenosine as substrate
Cu2+
-
10.6% residual activity at 0.1 M using inosine as substrate, 9.67% residual activity at 0.1 M using guanosine as substrate, complete inhibition at 0.1 M using adenosine as substrate
Fe2+
-
60.6% residual activity at 0.1 M using inosine as substrate, 54.8% residual activity at 0.1 M using guanosine as substrate, 66.6% residual activity at 0.1 M using adenosine as substrate
guanine
-
competitive
hypoxanthine
Mg2+
-
62.1% residual activity at 0.1 M using inosine as substrate, 74.2% residual activity at 0.1 M using guanosine as substrate, 75% residual activity at 0.1 M using adenosine as substrate
NaCN
-
60.6% residual activity at 0.1 M using inosine as substrate, 38.7% residual activity at 0.1 M using guanosine as substrate, 41.6% residual activity at 0.1 M using adenosine as substrate
nucleoside diphosphates
-
less effective inhibitor compared to nucleoside triphosphates, non competitive inhibition
nucleoside monophosphates
-
slight inhibition or no effect
nucleoside triphosphates
-
most potent inhibitor, non competitive inhibition
Theobromine
-
at alkaline pH