3.2.2.17: deoxyribodipyrimidine endonucleosidase

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For detailed information about deoxyribodipyrimidine endonucleosidase, go to the full flat file.

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Synonyms

5'dimer DNA glycosylase, bacteriophage T4 endonuclease V, Bsp-pdg, Chlorella virus pyrimidine dimer glycosylase, cis-syn cyclobutane pyrimidine dimer glycosylase, cis-syn trans-syn-II cyclobutane pyrimidine dimer glycosylase, cv-pdg1, denV, deoxyribonucleate pyrimidine dimer glycosidase, deoxyribopyrimidine endonucleosidase, dimer dependent endonuclease V, dimer specific M. luteus endonuclease, dimer-dependent endonuclease, dimericine, endodeoxyribonuclease (apurinic or apyrimidinic), endodeoxyribonuclease (pyrimidine dimer), endonuclease V, glycosylase/abasic (AP) lyase, PD-DNA glycosylase, PD-glycosylase, PD-specific DNA glycosylase, pyrimidine dimer DNA glycosylase, pyrimidine dimer glycosylase, pyrimidine dimer-specific glycosylase/AP lyase, T4 Endo V, T4 endonuclease V, T4 endonuclease V DNA repair enzyme, T4 PD-DNA-glycosylase, T4 Pdg, T4 pyrimidine dimer DNA glycosylase, T4 pyrimidine dimer DNA glycosylase/AP-lyase, T4 pyrimidine dimer glycosylase, T4 UV endonuclease, T4-induced UV endonuclease, T4-PDG, T4PDG, thymine photodimer repair enzyme, UV endonuclease, UV-specific endonuclease

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.17 deoxyribodipyrimidine endonucleosidase

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Results	in table
1	Activating Compound
25	AA Sequence
4	Application
11	Cloned(Commentary)
8	Crystallization (Commentary)
2	General Stability
7	Inhibitors
18	KM Value [mM]
10	Metals/Ions
11	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
45	Organism
2	PDB ID
7	pH Optimum
3	pH Range
13	Protein Variants
21	Purification (Commentary)
4	Reaction
5	Reaction Type
44	Reference
4	Source Tissue
3	Specific Activity [micromol/min/mg]
3	Storage Stability
48	Substrates and Products (Substrate)
5	Subunits
77	Synonyms
1	Systematic Name
2	Temperature Range [°C]
6	Temperature Stability [°C]

Crystallization

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Crystallization on EC 3.2.2.17 - deoxyribodipyrimidine endonucleosidase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

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Tequatrovirus T4

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170697, 170703, 171807, 171808, 171809, 171813

2 amino acids critical for T4-PDG catalysis, Thr2 and Glu23, known from x-ray crystal structure studies

Tequatrovirus T4

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171812

crystallized at 15°C by the hanging-drop vapor-diffusion method, co-crystal structure of T4-Pdg as a reduced covalent complex with an AP site-containing duplex oligodeoxynucleotide. This high-resolution structure reveals essential precatalytic and catalytic features, including flipping of the nucleotide opposite the AP site, a sharp kink (about 66°) in the DNA at the dimer site and the covalent bond linking the enzyme to the DNA

Tequatrovirus T4

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681394