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3.2.2.14: NMN nucleosidase

This is an abbreviated version!
For detailed information about NMN nucleosidase, go to the full flat file.

Word Map on EC 3.2.2.14

Reaction

beta-nicotinamide D-ribonucleotide
+
H2O
=
D-ribose 5-phosphate
 +
nicotinamide

Synonyms

NaR nucleosidase, nicotinamide mononucleotidase, nicotinamide mononucleotide glycohydrolase, nicotinamide mononucleotide nucleosidase, NMN glycohydrolase, NMNase, NMNGhase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.14 NMN nucleosidase

Inhibitors

Inhibitors on EC 3.2.2.14 - NMN nucleosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-phosphoribose 1-diphosphate
-
PRPP, inorganic polyphosphates, affinity of 5-phosphoribose 1-pyrophosphate for the enzyme is dependent on the activator concentration , inhibition mechanism with 5-phosphoribose 1-pyrophosphate is competitive with GTP
7-methylguanosine-5'-triphosphate
-
-
adenosine
-
addition of 1.4 mM, inhibition 54.7%
ADP-ribose
-
addition of 1-1.4 mM, inhibition 74.4%
AMP
-
addition of 1.4 mM AMP, inhibition 92.5%
D-ribose-5-phosphate
-
addition of 1.4 mM, inhibition 42.3%
dCMP
-
effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
desamido-NAD+
-
addition of 1 mM, inhibition 66.6%
dGMP
-
effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
EDTA
-
1 mM inhibits NMN hydrolysis by 30%
guanosine
-
addition of 1.4 mM, inhibition 44.6%
N-ethylmaleimide
-
50% inhibition at 80 mM
NAD+
-
greatly inhibited by intracellular levels of NAD+ and reduced NADH, addition of 1 mM NAD+, inhibition 73.2%
NADH
-
addition of 1 mM, inhibition 68.6%
NADP+
-
addition of 1 mM, inhibition 24%
nicotinamide hypoxanthine dinucleotide
-
addition of 1 mM nicotinamide hypoxanthine dinucleotide, inhibition 61.4%
p-chloromercuribenzoate
-
50% inhibition at 3 mM
pyridoxal 5'-phosphate
-
addition of 1.4 mM, inhibition 8.8%
pyridoxal HCl
-
addition of 1.4 mM, inhibition 5.2%
thio-NAD+
-
addition of 1 mM, inhibition 63.2%