3.2.2.1: purine nucleosidase
This is an abbreviated version!
For detailed information about purine nucleosidase, go to the full flat file.
Word Map on EC 3.2.2.1
-
3.2.2.1
-
salvage
-
trypanosoma
-
vivax
-
crithidia
-
fasciculata
-
pyrimidine-specific
-
n-glycosidic
-
iminoribitols
-
parkin
-
schramm
-
formycin
-
horenstein
-
trypanocidal
-
pharmacology
-
drug development
-
analysis
- 3.2.2.1
-
salvage
- trypanosoma
- vivax
-
crithidia
- fasciculata
-
pyrimidine-specific
-
n-glycosidic
- iminoribitols
- parkin
-
schramm
- formycin
-
horenstein
-
trypanocidal
- pharmacology
- drug development
- analysis
Reaction
Synonyms
6-oxopurine nucleosidase, CELE_Y43F8C.13, IAG nucleoside hydrolase, IAG-NH, IAG-nucleoside hydrolase, IAGNH, IG-NH, inosine-adenosine-guanosine nucleoside hydrolase, inosine-adenosine-guanosine-preferring nucleoside hydrolase, inosine-guanosine nucleoside hydrolase, inosine-guanosine-specific nucleoside hydrolase, inosine/adenosine/guanosinepreferring NH, IU-nucleoside hydrolase, IunH, N-ribosyl purine ribohydrolase, N-ribosyl-purine ribohydrolase, NSH3, nucleosidase, nucleosidase g, nucleoside hydrolase, PpNRH1, purine beta-ribosidase, purine hydrolase, purine NRH, Purine nucleosidase, purine nucleoside hydrolase, purine nucleoside N-ribohydrolase, purine ribonucleosidase, purine specific nucleoside hydrolase, purine-preferring nucleoside hydrolase, purine-specific hydrolase, purine-specific inosine-adenosine-guanosine nucleoside hydrolase, purine-specific inosineadenosine-guanosine nucleoside hydrolase, purine-specific NH, purine-specific nucleoside hydrolase, purine-specific ribonucleoside hydrolase, ribonucleoside hydrolase, rih1, rih2, RihC, SsIAG-NH, SslAG-NH, SSO2243, Tb927.3.2960, URH1, URH2, ZmNRH3
ECTree
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Reference on EC 3.2.2.1 - purine nucleosidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koszalka, G.W.; Krenitsky, T.A.
Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2-deoxyribonucleosidase
J. Biol. Chem.
254
8185-8193
1979
Leishmania mexicana
Atkins, C.A.; Shelp, B.J.; Storer, P.J.
Purification and properties of purine nucleosidase from N2-fixing nodules of cowpea (Vigna unguiculata)
J. Plant Physiol.
134
447-452
1989
Vigna unguiculata
-
Larsen, K.; Jochimsen, B.U.
Appearance of purine-catabolizing enzymes in fix+ and fix- root nodules on soybean and effect of oxygen on the expression of the enzymes in callus tissue
Plant Physiol.
85
452-456
1987
Glycine max
Hassan, H.F.; Coombs, G.H.
A comparative study of the purine- and pyrimidine-metabolising enzymes of a range of trypanosomatids
Comp. Biochem. Physiol. B
84
217-223
1986
Crithidia fasciculata, Herpetomonas muscarum, Leishmania donovani, Leishmania mexicana, Leishmania tarentolae
-
Christensen, T.M.I.E.; Jochimsen, B.U.
Enzymes of ureide synthesis in pea and soybean
Plant Physiol.
72
56-59
1983
Bradyrhizobium japonicum, Glycine max, Pisum sativum, Rhizobium leguminosarum
Hassan, H.F.; Coombs, G.H.
Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes
Exp. Parasitol.
59
139-150
1985
Leishmania mexicana
Mattoo, A.K.; Dandekar, A.M.; Trivedi, J.P.; Majmudar, G.H.; Patel, D.M.
Regulation of Neurospora crassa nucleosidases by some environmental factors
Z. Allg. Mikrobiol.
19
253-260
1979
Neurospora crassa
Kuwahara, M.; Fujii, T.
Purification and some properties of NAD-degrading purine nucleosidase from Aspergillus niger
Can. J. Biochem.
56
345-348
1978
Aspergillus niger
Agrawal, P.K.; Narayan, R.; Gollakota, K.G.
The influence of growth and sporulation temperature on heat resistance of a bacterial nucleosidase
Biochem. Biophys. Res. Commun.
63
562-570
1975
Bacillus cereus
Parkin, D.W.; Horenstein, B.A.; Abdulah, D.R.; Estupinan, B.; Schramm, V.L.
Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism
J. Biol. Chem.
266
20658-20665
1991
Crithidia fasciculata
Parkin, D.W.
Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei
J. Biol. Chem.
271
21713-21719
1996
Trypanosoma brucei
Agrawal, P.K.; Narayan, R.; Gollakota, K.G.
Study of heat resistance in a bacterial nucleosidase
Biochem. Biophys. Res. Commun.
60
111-117
1974
Bacillus cereus
Mattoo, A.K.; Shah, Z.M.
Nucleotide degrading enzymes in Neurospora crassa
Z. Allg. Mikrobiol.
14
581-591
1974
Neurospora crassa
Srivastava, O.P.; Fitz-James, P.C.
Alteration by heat activation of enzymes localized in spore coats of Bacillus cereus
Can. J. Microbiol.
27
408-416
1981
Bacillus cereus
Nolan, L.L.; Kidder, G.W.
Caffeine: its action on purine metabolizing enzymes
Biochem. Biophys. Res. Commun.
91
253-262
1979
Crithidia fasciculata
Reese, E.T.; Maguire, A.H.
Purine ribonucleosidase g from Aspergillus foetidus
J. Bacteriol.
96
1696-1699
1968
Aspergillus foetidus
Takagi, Y.; Horecker, B.L.
Purification and properties of a bacterial riboside riboside hydrolase
J. Biol. Chem.
225
77-86
1956
Lactobacillus delbrueckii
Hassan, M.M.; El-Zainy, T.A.; Alla, A.M.
Studies of some of the properties of purine nucleoside hydrolase from Aspergillus niger
Egypt. J. Chem.
22
189-196
1979
Aspergillus niger
-
Gutteridge, W.E.; Davies, M.J.
Enzymes of purine salvage in Trypanosoma cruzi
FEBS Lett.
127
211-214
1981
Trypanosoma cruzi
Canale-Parola, E.; Kidder, G.W.
Enzymatic activities for interconversion of purines in spirochetes
J. Bacteriol.
152
1105-1110
1982
Spirochaeta aurantia, Treponema denticola, Treponema succinifaciens, Spirochaeta aurantia M1
Furneaux, R.H.; Schramm, V.L.; Tyler, P.C.
Transition state analogue inhibitors of protozoan nucleoside hydrolases
Bioorg. Med. Chem.
7
2599-2606
1999
Trypanosoma brucei
Parkin, D.W.; Limberg, G.; Tyler, P.C.; Furneaux, R.H.; Chen, X.Y.; Schramm, V.L.
Isozyme-specific transition state inhibitors for the trypanosomal nucleoside hydrolases
Biochemistry
36
3528-3534
1997
Trypanosoma brucei
Abu-Shady, M.R.; Elshafei, A.M.; El-Beih, F.M.; Mohamed, L.A.
Hydrolytic cleavage of purine ribunucleosides by extracts of Aspergillus terricola
Acta Microbiol. Pol.
43
297-304
1994
Aspergillus terricola
Versees, W.; van Holsbeke, E.; de Vos, S.; Decanniere, K.; Zegers, I.; Steyaert, J.
Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni
Acta Crystallogr. Sect. D
D59
1087-1089
2003
Caenorhabditis elegans, Campylobacter jejuni
Ogawa, J.; Takeda, S.; Xie, S.X.; Hatanaka, H.; Ashikari, T.; Amachi, T.; Shimizu, S.
Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi
Appl. Environ. Microbiol.
67
1783-1787
2001
Brucella anthropi (E15229), Brucella anthropi
Ribeiro, J.M.; Valenzuela, J.G.
The salivary purine nucleosidase of the mosquito, Aedes aegypti
Insect Biochem. Mol. Biol.
33
13-22
2003
Aedes aegypti, no activity in Anopheles gambiae, no activity in Lutzomyia longipalpis, no activity in Culex quinquefasciatus
Versees, W.; Decanniere, K.; Pelle, R.; Depoorter, J.; Brosens, E.; Parkin, D.W.; Steyaert, J.
Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax
J. Mol. Biol.
307
1363-1379
2001
Trypanosoma vivax (Q9GPQ4), Trypanosoma vivax
Zaks, A.; Dodds, D.R.
Application of biocatalysts and biotransformation to the synthesis of pharmaceuticals
Drug Discov. Today
2
513-531
1997
Pectobacterium carotovorum
-
Hansen, M.R.; Dandanell, G.
Purification and characterization of RihC, a xanthosine-inosine-uridine-adenosine-preferring hydrolase from Salmonella enterica serovar Typhimurium
Biochim. Biophys. Acta
1723
55-62
2005
Salmonella enterica
Hunt, C.; Gillani, N.; Farone, A.; Rezaei, M.; Kline, P.C.
Kinetic isotope effects of nucleoside hydrolase from Escherichia coli
Biochim. Biophys. Acta
1751
140-149
2005
Escherichia coli
Versees, W.; Barlow, J.; Steyaert, J.
Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis
J. Mol. Biol.
359
331-346
2006
Trypanosoma vivax
Kim, H.S.; Lee, J.H.; Lee, W.S.; Bang, W.G.
Genes encoding ribonucleoside hydrolase 1 and 2 from Corynebacterium ammoniagenes
Microbiology
152
1169-1177
2006
Corynebacterium ammoniagenes
Evans, G.B.; Furneaux, R.H.; Greatrex, B.; Murkin, A.S.; Schramm, V.L.; Tyler, P.C.
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases
J. Med. Chem.
51
948-956
2008
Bos taurus, Homo sapiens, Plasmodium falciparum
Barlow, J.N.; Steyaert, J.
Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax
Biochim. Biophys. Acta
1774
1451-1461
2007
Trypanosoma vivax
Goeminne, A.; McNaughton, M.; Bal, G.; Surpateanu, G.; Van Der Veken, P.; De Prol, S.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors
Eur. J. Med. Chem.
43
315-326
2008
Trypanosoma vivax
Miller, T.K.; Patel, C.; Selitrennikoff, C.P.
Construction of a Saccharomyces cerevisiae strain expressing the Leishmania major nucleoside hydrolase gene
Int. J. Antimicrob. Agents
29
103-107
2007
Leishmania major
Sterk, M.; Mueller, J.; Hemphill, A.; Mueller, N.
Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin
Microbiology
153
4150-4158
2007
Giardia intestinalis
Porcelli, M.; Peluso, I.; Marabotti, A.; Facchiano, A.; Cacciapuoti, G.
Biochemical characterization and homology modeling of a purine-specific ribonucleoside hydrolase from the archaeon Sulfolobus solfataricus: insights into mechanisms of protein stabilization
Arch. Biochem. Biophys.
483
55-65
2009
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Versees, W.; Goeminne, A.; Berg, M.; Vandemeulebroucke, A.; Haemers, A.; Augustyns, K.; Steyaert, J.
Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors
Biochim. Biophys. Acta
1794
953-960
2009
Trypanosoma vivax (Q9GPQ4)
Goeminne, A.; Berg, M.; McNaughton, M.; Bal, G.; Surpateanu, G.; Van der Veken, P.; De Prol, S.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase
Bioorg. Med. Chem.
16
6752-6763
2008
Trypanosoma vivax (Q9GPQ4), Trypanosoma vivax
Berg, M.; Bal, G.; Goeminne, A.; Van der Veken, P.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors
ChemMedChem
4
249-260
2009
Trypanosoma vivax (Q9GPQ4)
Vandemeulebroucke, A.; De Vos, S.; Van Holsbeke, E.; Steyaert, J.; Versees, W.
A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax
J. Biol. Chem.
283
22272-22282
2008
Trypanosoma vivax (Q9GPQ4)
Liang, L.; He, X.; Liu, G.; Tan, H.
The role of a purine-specific nucleoside hydrolase in spore germination of Bacillus thuringiensis
Microbiology
154
1333-1340
2008
Bacillus thuringiensis (A7UHH1), Bacillus thuringiensis
Berg, M.; Kohl, L.; Van der Veken, P.; Joossens, J.; Al-Salabi, M.I.; Castagna, V.; Giannese, F.; Cos, P.; Versees, W.; Steyaert, J.; Grellier, P.; Haemers, A.; Degano, M.; Maes, L.; de Koning, H.P.; Augustyns, K.
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis
Antimicrob. Agents Chemother.
54
1900-1908
2010
Trypanosoma brucei brucei, Trypanosoma vivax
Vandemeulebroucke, A.; Minici, C.; Bruno, I.; Muzzolini, L.; Tornaghi, P.; Parkin, D.W.; Versees, W.; Steyaert, J.; Degano, M.
Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei
Biochemistry
49
8999-9010
2010
Trypanosoma brucei brucei
Riegler, H.; Geserick, C.; Zrenner, R.
Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation
New Phytol.
191
349-359
2011
Arabidopsis thaliana
Jung, B.; Hoffmann, C.; Moehlmann, T.
Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines
Plant J.
65
703-711
2011
Arabidopsis thaliana
Minici, C.; Cacciapuoti, G.; De Leo, E.; Porcelli, M.; Degano, M.
New determinants in the catalytic mechanism of nucleoside hydrolases from the structures of two isozymes from Sulfolobus solfataricus
Biochemistry
51
4590-4599
2012
Saccharolobus solfataricus (Q97WH6), Saccharolobus solfataricus P2 (Q97WH6)
Porcelli, M.; De Leo, E.; Del Vecchio, P.; Fuccio, F.; Cacciapuoti, G.
Thermal unfolding of nucleoside hydrolases from the hyperthermophilic archaeon Sulfolobus solfataricus: role of disulfide bonds
Protein Pept. Lett.
19
369-374
2012
Saccharolobus solfataricus
Giannese, F.; Berg, M.; Van der Veken, P.; Castagna, V.; Tornaghi, P.; Augustyns, K.; Degano, M.
Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor
Acta Crystallogr. Sect. D
69
1553-1566
2013
Trypanosoma brucei, Trypanosoma brucei TREU927
Porcelli, M.; De Leo, E.; Marabotti, A.; Cacciapuoti, G.
Site-directed mutagenesis gives insights into substrate specificity of Sulfolobus solfataricus purine-specific nucleoside hydrolase
Ann. Microbiol.
62
881-887
2012
Saccharolobus solfataricus (Q97WH6)
Chen, N.; Ge, H.; Xu, J.; Cao, Z.; Wu, R.
Loop motion and base release in purine-specific nucleoside hydrolase: a molecular dynamics study
Biochim. Biophys. Acta
1834
1117-1124
2013
Trypanosoma vivax
Kopecna, M.; Blaschke, H.; Kopecny, D.; Vigouroux, A.; Koncitikova, R.; Novak, O.; Kotland, O.; Strnad, M.; Morera, S.; von Schwartzenberg, K.
Structure and function of nucleoside hydrolases from Physcomitrella patens and maize catalyzing the hydrolysis of purine, pyrimidine, and cytokinin ribosides
Plant Physiol.
163
1568-1583
2013
Physcomitrium patens (A9TXA6), Physcomitrium patens, Zea mays (B6T563), Zea mays, Physcomitrium patens Gransden 2004 (A9TXA6)
Ha, C.; Fatima, A.; Gaurav, A.
In silico investigation of flavonoids as potential trypanosomal nucleoside hydrolase inhibitors
Adv. Bioinformatics
2015
826047
2015
Trypanosoma brucei (Q57ZL6), Trypanosoma brucei, Trypanosoma brucei 927/4 GUTat10.1 (Q57ZL6)
Mitsukawa, Y.; Hibi, M.; Matsutani, N.; Horinouchi, N.; Takahashi, S.; Ogawa, J.
A novel nucleoside hydrolase from Lactobacillus buchneri LBK78 catalyzing hydrolysis of 2-O-methylribonucleosides
Biosci. Biotechnol. Biochem.
80
1568-1576
2016
Lentilactobacillus buchneri
Chen, N.; Zhao, Y.; Lu, J.; Wu, R.; Cao, Z.
Mechanistic insights into the rate-limiting step in purine-specific nucleoside hydrolase
J. Chem. Theory Comput.
11
3180-3188
2015
Trypanosoma vivax (Q9GPQ4)
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