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3.2.1.63: 1,2-alpha-L-fucosidase

This is an abbreviated version!
For detailed information about 1,2-alpha-L-fucosidase, go to the full flat file.

Word Map on EC 3.2.1.63

Reaction

(Glcalpha(1-4))n
+
H2O
=
(Glcalpha(1-4))n-4
+
(Glcalpha(1-4))4

Synonyms

1,2-alpha-L-fucosidase, Afc3, AfcA, AfcA protein, alpha(1,2) fucosidase, alpha-(1--> 2)-L-fucosidase, alpha-fucosidase, alpha-L-fucosidase, alpha-L-fucosidase II, alpha1,2-FUC, alpha1,2-fucosidase, bfo_2737, FgFCO1, Fuc1, FucNaFLD, fucosidase, 1,2-alpha-L-, More

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.63 1,2-alpha-L-fucosidase

Substrates Products

Substrates Products on EC 3.2.1.63 - 1,2-alpha-L-fucosidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2'-fucosyllactose + H2O
?
show the reaction diagram
-
hydrolysis by the Fuc domain of AfcA. N423 and D766 are critical for activating an attacking water molecule and N421 is critical for maintaining the water molecule and the side-chain of E566 (a general acid) in their proper orientations
-
-
?
2'-fucosyllactose + H2O
fucose + lactose
show the reaction diagram
2'-fucosyllactose + H2O
L-fucose + lactose
show the reaction diagram
2'-L-fucosyllactose + H2O
L-fucose + lactose
show the reaction diagram
2-fucosyllactitol + H2O
fucose + lactitol
show the reaction diagram
-
-
-
-
?
2-O-alpha-L-fucopyranosyl-D-galactose + H2O
L-fucose + galactose
show the reaction diagram
4-methylumbelliferyl alpha-L-fucopyranoside + H2O
4-methylumbelliferone + L-fucopyranose
show the reaction diagram
4-nitrophenyl alpha-L-fucopyranoside + H2O
4-nitrophenol + L-fucopyranose
show the reaction diagram
4-nitrophenyl-alpha-L-fucoside + H2O
4-nitrophenol + L-fucose
show the reaction diagram
-
-
-
?
alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-D-GlcNAc + H2O
L-fucose + ?
show the reaction diagram
alpha-Fuc-(1-2)-beta-Gal-(1-3)-beta-GlcNAc-(1-3)-beta-Gal-(1-4)-beta-Glc + H2O
alpha-L-fucose + beta-Gal-(1-3)-beta-GlcNAc-(1-3)-beta-Gal-(1-4)-beta-Glc
show the reaction diagram
-
i.e. lacto-N-fucopentaose I
-
?
alpha-Fuc-(1-2)-beta-Gal-(1-3)-beta-GlcNAc-(1-3)-beta-Gal-(1-4-)-beta-Glc + H2O
alpha-L-fucose + beta-Gal-(1-3)-beta-GlcNAc-(1-3)-beta-Gal-(1-4)-beta-Glc
show the reaction diagram
Bacillus fulminans
-
-
-
-
?
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O
L-fucose + ?
show the reaction diagram
i.e. blood group antigen H pentaose type-1, weak substrate
-
-
?
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-D-Gal + H2O
L-fucose + ?
show the reaction diagram
i.e. blood group antigen H-tetraose type 2
-
-
?
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + H2O
L-fucose + ?
show the reaction diagram
i.e. blood group antigen H triose type-2
-
-
?
alpha-L-Fuc-(1->2)-D-Gal + H2O
L-fucose + ?
show the reaction diagram
-
-
-
-
?
alpha-L-Fuc-(1->6)-beta-D-GlcNAc + H2O
?
show the reaction diagram
beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GalNAc-(1->3)-D-Gal
L-fucose + ?
show the reaction diagram
i.e. Lewis a tetraose
-
-
?
beta-L-fucosyl fluoride + lactose + H2O
?
show the reaction diagram
-
Hehre resynthesis-hydrolysis is catalyzed by the wild-type Fuc domain of AfcA. Conversion of the inverting alpha-glycosidase to a glycosynthase
-
-
?
biotin-PAA-alpha-L-fucose + H2O
?
show the reaction diagram
-
-
-
?
blood group substance H + H2O
?
show the reaction diagram
bovine submaxillary mucin + H2O
L-fucose + ?
show the reaction diagram
Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc + H2O
L-fucose + Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc
show the reaction diagram
-
i.e. lacto-N-fucopentaose I, at 29% of the activity with 2'-fucosyllactose
-
-
?
Fucalpha(1-2)Galbeta(1-4)Glc + H2O
L-fucose + Galbeta(1-4)Glc
show the reaction diagram
-
i.e. 2'-fucosyllactose
-
-
?
Galbeta(1-4)(Fucalpha(1-3))Glc + H2O
?
show the reaction diagram
-
i.e. 3-fucosyllactose, at 0.85% of the activity with 2'-fucosyllactose
-
-
?
glycopeptide desialyzed porcine submaxillary mucin + H2O
?
show the reaction diagram
Bacillus fulminans
-
-
-
-
?
glycoprotein + H2O
?
show the reaction diagram
Bacillus fulminans
-
-
-
-
?
lacto-N-fucopentaose I
?
show the reaction diagram
Bacillus fulminans
-
-
-
-
?
lacto-N-fucopentaose I + H2O
?
show the reaction diagram
methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside + H2O
L-fucose + methyl beta-D-galactoside
show the reaction diagram
mucin + H2O
?
show the reaction diagram
-
-
-
?
mucin + H2O
L-fucose + ?
show the reaction diagram
N-acetyl-propargyl alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc + H2O
L-fucose + ?
show the reaction diagram
i.e. blood group antigen H-pentaose type-2 beta-N-acetyl propargyl
-
-
?
O-alpha-L-fucose-(1-2)-O-beta-D-galactose-(1-4)-D-glucose + H2O
L-fucose + lactose
show the reaction diagram
porcine gastric mucin + H2O
?
show the reaction diagram
-
at 33% of the activity with 2'-fucosyllactose
-
-
?
porcine gastric mucin + H2O
L-fucose + ?
show the reaction diagram
-
-
-
-
?
porcine submaxillary mucin + H2O
?
show the reaction diagram
Bacillus fulminans
-
-
-
-
?
submaxillary glycoprotein + H2O
L-fucose + ?
show the reaction diagram
-
degradation of blood group substances
-
?
additional information
?
-