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3.2.1.63: 1,2-alpha-L-fucosidase

This is an abbreviated version!
For detailed information about 1,2-alpha-L-fucosidase, go to the full flat file.

Word Map on EC 3.2.1.63

Reaction

(Glcalpha(1-4))n
+
H2O
=
(Glcalpha(1-4))n-4
 +
(Glcalpha(1-4))4

Synonyms

1,2-alpha-L-fucosidase, Afc3, AfcA, AfcA protein, alpha(1,2) fucosidase, alpha-(1--> 2)-L-fucosidase, alpha-fucosidase, alpha-L-fucosidase, alpha-L-fucosidase II, alpha1,2-FUC, alpha1,2-fucosidase, bfo_2737, FgFCO1, Fuc1, FucNaFLD, fucosidase, 1,2-alpha-L-, More

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.63 1,2-alpha-L-fucosidase

Inhibitors

Inhibitors on EC 3.2.1.63 - 1,2-alpha-L-fucosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol
-
(2R,3S,4S,5R,6S)-2-benzyl-6-methylpiperidine-3,4,5-triol
-
(2S,3R,4S,5S,6R)-2-methyl-6-(propan-2-yl)piperidine-3,4,5-triol
-
2-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
2-cyclopentyl-2-phenyl-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
3'-fucosyllactose
-
3-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide
-
9-oxo-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-9H-fluorene-1-carboxamide
-
alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-D-GlcNAc
i.e. blood group antigen B-tetraose type 2
alpha-D-GalNAc-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->4)-D-GlcNAc
i.e. blood group antigen A-tetraose type 2
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc
i.e. Lewisb tetraose
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-D-Gal
i.e. blood group antigen H-tetraose type 2
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc
i.e. blood group antigen H-triose type 2
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc
i.e. Lewisy tetraose
BaCl2
-
1 mM, 63% inhibition
beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GalNAc-(1->3)-D-Gal
i.e. Lewis a tetraose
beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-Glc
i.e. Lewisa hexaose
beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-D-Gal
i.e. Lewisx tetraose
CaCl2
-
1 mM, 60% inhibition
Co2+
0.8fold decrease of activity at 10 mM
CoCl2
-
1 mM, 38% inhibition
CuSO4
-
1 mM, 86% inhibition
cysteine
-
1 mM, 27% inhibition
D-mannose
-
10 mM, 22% inhibition
deoxycholate
Bacillus fulminans
-
-
deoxyfuconojirimycin
dithiothreitol
-
1 mM, 22% inhibition
FeSO4
-
1 mM, complete inhibition
glutathione
-
1 mM, 21% inhibition
iodoacetamide
-
-
L-fucose
lactose
-
10 mM, 27% inhibition
MgCl2
-
-
Mn2+
Bacillus fulminans
-
-
N-acetyl-propargyl alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc
i.e. blood group antigen H-pentaose type-2 beta-N-acetyl propargyl
N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide
-
N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-2-carboxamide
-
N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
NEM
-
0.1 mM, 24% inhibition
Ni2+
1.0fold decrease of activity at 10 mM
NiSO4
-
1 mM, 59% inhibition
p-chloromercuribenzoate
-
-
p-chloromercuriphenylsulfonate
-
1 mM, 12% inhibition
p-mercuribenzoate
-
1 mM, 23% inhibition
SDS
Bacillus fulminans
-
-
ZnCl2
-
1 mM, 43% inhibition
additional information
no substantial effect on alpha-L-fucosidase activity upon the addition of 10 mM EDTA or 300 mM NaCl
-