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3.2.1.51: alpha-L-fucosidase

This is an abbreviated version!
For detailed information about alpha-L-fucosidase, go to the full flat file.

Word Map on EC 3.2.1.51

Reaction

an alpha-L-fucoside
+
H2O
=
L-fucose
 +
an alcohol

Synonyms

acid hydrolase, Afc2, Afc3, AFU, Alf1_Wf, alfA, alfB, alfC, alpha-fuc, alpha-fucosidase, alpha-L fucosidase, alpha-L-fucosidase, alpha-L-fucosidase 1, alpha-L-fucosidase 2, alpha-L-fucosidase I, alpha-L-fucosidase iso2, alpha-L-fucosidase isoenzyme 1, Alpha-L-fucoside fucohydrolase, alpha-L-fucoside fucohydrolase 2, alphafuc, bfo_2737, BgFUC, Eo0918, Eo3066, Eo3812, FpFucA, FucA, Fuca1, Fuca2, Fuca3, FucFA, fucosidase, alpha-L-1, tissue, h-Fuc, mfuc1, mfuc2, mfuc3, mfuc4, mfuc5, mfuc6, mfuc7, Pap-Alf, serum AFU, serum alpha-L-fucosidase, TfFuc1, TMalphafuc

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.51 alpha-L-fucosidase

Natural Substrates Products

Natural Substrates Products on EC 3.2.1.51 - alpha-L-fucosidase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2'-fucosyllactitol + H2O
alpha-L-fucose + lactitol
show the reaction diagram
3-fucosyllactitol + H2O
alpha-L-fucose + lactitol
show the reaction diagram
4-nitrophenyl-alpha-L-fucopyranoside + H2O
4-nitrophenol + L-fucose
show the reaction diagram
-
-
-
-
?
6-O-alpha-L-fucopyranosyl-N-acetylglucosamine + H2O
alpha-L-fucopyranose + N-acetyl-glucosamine
show the reaction diagram
-
Fuc-alpha-1,6-GlcNAc-linkage most susceptible
-
?
alpha-L-Fuc-(1-2)-D-Gal + N-acetyl-D-glucosamine
alpha-L-Fuc-(1-3)-D-GlcNAc + D-galactose
show the reaction diagram
-
same yield of transglycosylation and hydrolysis products
-
?
alpha-L-Fuc-(1-3)-D-Gal + N-acetyl-D-glucosamine
alpha-L-Fuc-(1-3)-D-GlcNAc + D-galactose
show the reaction diagram
-
slower hydrolysis than for the alpha-(1-6)- or alpha-(1-2)-isomers, transglycosylation activity
-
?
alpha-L-Fuc-(1-6)-D-Gal + N-acetyl-D-glucosamine
alpha-L-Fuc-(1-6)-D-GlcNAc + D-galactose
show the reaction diagram
-
same yield of transglycosylation and hydrolysis products
-
?
alpha-L-fucopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-galactitol + H2O
alpha-L-fucose + beta-D-galactopyranosyl-(1->4)-2-acetamido-2-deoxy-D-galactitol
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-2)-Gal + H2O
alpha-L-fucose + D-galactose
show the reaction diagram
Fuc-alpha-(1-2)-Gal-beta-(1-3)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O
alpha-L-fucose + Gal-beta-(1-3)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
Fuc-alpha-(1-2)-Gal-beta-(1-3)-GlcNAc-beta-(1-4)-Glc + H2O
Gal-beta-(1-3)-GlcNAc-beta-(1-4)-Glc + alpha-L-fucose
show the reaction diagram
Fuc-alpha-(1-2)-Gal-beta-(1-3)-[Fuc-alpha-(1-4)]-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O
Gal-beta-(1-3)-[Fuc-alpha-(1-4)]-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc + alpha-L-fucose
show the reaction diagram
-
lacto-N-difucohexaitol I, NaBH4-reduced oligosaccharide
-
?
Fuc-alpha-(1-2)-Gal-beta-(1-4)-Glc + H2O
alpha-L-fucose + lactose
show the reaction diagram
Fuc-alpha-(1-2)-Gal-beta-(1-4)-sorbitol + H2O
alpha-L-fucose + Gal-beta-(1-4)-sorbitol
show the reaction diagram
-
alpha-fucosidase II, does not cleave alpha-(1-4)-GlcNAc-, alpha-(1-3)-GlcNAc- or alpha-(1-6)-GlcNAc-linkages and does not act on lacto-N-fucopentaoitol I, which has a Fuc-alpha-(1-2)-Gal-group
-
?
Fuc-alpha-(1-2)-Gal-beta-(1-4)-[Fuc-alpha-(1-3)]-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O
Gal-beta-(1-4)-[Fuc-alpha-(1-3)]-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc + alpha-L-fucose
show the reaction diagram
-
hydrolysis of Fuc-alpha-(1-2)-Gal- and Fuc-alpha-(1-4)-GlcNAc- and Fuc-alpha-(1-6)-GlcNAc- linkages but hardly the Fuc-alpha-(1-3)-GlcNAc-linkage
-
?
Fuc-alpha-(1-2)-Glc + H2O
alpha-L-fucose + D-glucose
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-2)-Xyl + H2O
alpha-L-fucose + D-xylose
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-3)-Gal + H2O
alpha-L-fucose + D-galactose
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-3)-Gal-beta-(1-4)-Glc + H2O
alpha-D-fucose + lactose
show the reaction diagram
Fuc-alpha-(1-3)-Glc + H2O
alpha-L-fucose + D-glucose
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-3)-GlcNAc + H2O
alpha-L-fucose + N-acetyl-D-glucosamine
show the reaction diagram
Fuc-alpha-(1-4)-GlcNAc + H2O
alpha-L-fucose + N-acetyl-D-glucosamine
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-6)-Gal + H2O
alpha-L-fucose + D-galactose
show the reaction diagram
-
-
-
?
Fuc-alpha-(1-6)-GlcNAc + H2O
alpha-L-fucose + N-acetyl-D-glucosamine
show the reaction diagram
Fuc-alpha-(1-6)-GlcNAc-beta-Asn + H2O
alpha-L-fucose + N-acetyl-D-glucosaminyl-Asn
show the reaction diagram
-
-
-
?
Fuc-alpha-(1->2)-Gal-beta-(1->3)-[Fuc-alpha-(1->6)]GlcNAc-beta-(1->3)-Gal-beta-(1->4)GlcNAc + H2O
alpha-L-fucose + Gal-beta-(1->3)-[Fuc-alpha-(1->6)]GlcNAc-beta-(1->3)-Gal-beta-(1->4)GlcNAc
show the reaction diagram
-
low activity
-
?
Fuc-alpha-(1->2)-Gal-beta-(1->3)-[Fuc-alpha-(1->6)]GlcNAc-beta-(1->3)-Gal-beta-(1->4)GlcNAc + H2O + H2O
alpha-L-fucose + Fuc-alpha-(1->2)-Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)GlcNAc + H2O
show the reaction diagram
Bacillus fulminans
-
-
-
?
fucoidan + H2O
alpha-L-fucose + ?
show the reaction diagram
-
-
-
?
Gal-beta-(1-3)-GlcNAc-beta-(1-3)-[Fuc-alpha-(1-4)]-Gal-beta-(1-4)-Glc + H2O
alpha-L-fucose + Gal-beta-(1-3)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
Gal-beta-(1-4)-GlcNAc-[Fuc-alpha-(1-4)]-beta-(1-3)-Gal-beta-(1-4)-Glc + H2O
alpha-L-fucose + Gal-beta-(1-4)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
Gal-beta-(1-4)[Fuc-alpha-(1-3)]-Glc + H2O
Gal-beta-(1-4)-Glc + alpha-L-fucose
show the reaction diagram
-
very slow hydrolysis, NaBH4-reduced oligosaccharide
-
?
GalNAc-alpha-(1-3)-Gal-[Fuc-alpha-(1-2)] + H2O
alpha-L-fucose + GalNAc-alpha-(1-3)-Gal
show the reaction diagram
gastric mucin + H2O
alpha-L-fucose + ?
show the reaction diagram
glycopeptide + H2O
alpha-L-fucose + ?
show the reaction diagram
glycoprotein + H2O
alpha-L-fucose + ?
show the reaction diagram
glycosphingolipid + H2O
alpha-L-fucose + ?
show the reaction diagram
-
blood-group active types B and H
-
?
gp120 oligosaccharides + H2O
alpha-L-fucose + ?
show the reaction diagram
-
released from recombinant CHO cell-produced gp120, glycoproteins containing fucose in alpha-1,3- and alpha-1,6-linkages are no substrates
-
?
IgG Fc peptide + H2O
alpha-L-fucose + ?
show the reaction diagram
-
human, rabbit, horse
-
?
IgG L peptide + H2O
alpha-L-fucose + ?
show the reaction diagram
-
-
-
?
lacto-N-fucopentaitol III + H2O
alpha-L-fucose + ?
show the reaction diagram
lacto-N-fucopentaose II + H2O
alpha-L-fucose + Gal-beta-(1-3)-GlcNAc-beta-(1-3)-Gal-beta-(1-4)-Glc
show the reaction diagram
lactoferrin + H2O
alpha-L-fucose + ?
show the reaction diagram
-
low activity
-
?
LH-beta peptic glycopeptide + H2O
alpha-L-fucose + ?
show the reaction diagram
-
-
-
?
meconium H-1 + H2O
alpha-L-fucose + ?
show the reaction diagram
Bacillus fulminans
-
-
-
?
meconium H-2 + H2O
alpha-L-fucose + ?
show the reaction diagram
Bacillus fulminans
-
-
-
?
meconium X-1 + H2O
alpha-L-fucose + ?
show the reaction diagram
Bacillus fulminans
-
low activity
-
?
milk + H2O
alpha-L-fucose + ?
show the reaction diagram
-
human
-
?
oligosaccharide + H2O
alpha-L-fucose + ?
show the reaction diagram
orosomucoid + H2O
alpha-L-fucose + ?
show the reaction diagram
-
low activity, higher activity if desialyzed
-
?
saliva + H2O
alpha-L-fucose + ?
show the reaction diagram
submaxillary mucin + H2O
alpha-L-fucose + ?
show the reaction diagram
thyroglobulin + H2O
alpha-L-fucose + ?
show the reaction diagram
[Man-alpha-(1->6)]-[Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-[Fuc-alpha-(1->6)]GlcNAc + H2O
[Man-alpha-(1->6)]-[Man-alpha-(1->3)]-Man-beta-(1->4)-GlcNAc-beta-(1->4)-GlcNAc + alpha-L-fucose
show the reaction diagram
-
-
-
?
additional information
?
-
-
the enzyme is able to catalyse the hydrolysis of fucosyl units of Ascophyllum nodosum fucoidan
-
-
?