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3.2.1.51: alpha-L-fucosidase

This is an abbreviated version!
For detailed information about alpha-L-fucosidase, go to the full flat file.

Word Map on EC 3.2.1.51

Reaction

an alpha-L-fucoside
+
H2O
=
L-fucose
 +
an alcohol

Synonyms

acid hydrolase, Afc2, Afc3, AFU, Alf1_Wf, alfA, alfB, alfC, alpha-fuc, alpha-fucosidase, alpha-L fucosidase, alpha-L-fucosidase, alpha-L-fucosidase 1, alpha-L-fucosidase 2, alpha-L-fucosidase I, alpha-L-fucosidase iso2, alpha-L-fucosidase isoenzyme 1, Alpha-L-fucoside fucohydrolase, alpha-L-fucoside fucohydrolase 2, alphafuc, bfo_2737, BgFUC, Eo0918, Eo3066, Eo3812, FpFucA, FucA, Fuca1, Fuca2, Fuca3, FucFA, fucosidase, alpha-L-1, tissue, h-Fuc, mfuc1, mfuc2, mfuc3, mfuc4, mfuc5, mfuc6, mfuc7, Pap-Alf, serum AFU, serum alpha-L-fucosidase, TfFuc1, TMalphafuc

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.51 alpha-L-fucosidase

KI Value

KI Value on EC 3.2.1.51 - alpha-L-fucosidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
12 - 125
(1R,2R,3R,4R,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
22 - 188
(1R,2R,3R,4S,5R)-4-amino-5-methylcyclopentane-1,2,3-triol
0.0000152 - 0.0000163
(2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol
0.006
(2S,3R,4S,5R)-2-(propan-2-yl)piperidine-3,4,5-triol
-
-
0.005
(2S,3R,4S,5R)-2-benzylpiperidine-3,4,5-triol
-
-
0.000237
(2S,3R,4S,5S)-2-methyl-5-(phenylamino)pyrrolidine-3,4-diol
-
-
0.00008
(2S,3S,4R,5S)-2-(1H-benzimidazol-2-yl)-5-methylpyrrolidine-3,4-diol
-
-
0.00004
(2S,3S,4R,5S)-2-[(biphenyl-4-ylamino)methyl]-5-methylpyrrolidine-3,4-diol
-
-
0.0016
(5S,6R,7S)-6,7-dihydroxy-5-[(1S)-1,2-dihydroxyethyl]-4-azaspiro[2.4]heptane
-
-
200 - 1100
(R)-2-aminobutanol
350
(R)-2-aminobuthanol
-
pH 6.8, 25°C, epididymis
100 - 1300
(S)-2-aminobutanol
125
(S)-2-aminobuthanol
-
pH 6.8, 25°C, epididymis
0.00002 - 7.1
1-deoxyfuconojirimycin
1
1-deoxygalactonojirimycin
-
pH 4, 60°C
0.034
1-deoxymannojirimycin
-
pH 4, 60°C
1
1-deoxynojirimycin
-
pH 4, 60°C
0.000475
2-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
-
0.004 - 26
2-(hydroxymethyl)-5-methylpyrrolidine-3,4-diol
-
competitive or uncompetitive inhibition, depending on conformation
0.000018
2-cyclopentyl-2-phenyl-N-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl)methyl)acetamide
-
0.001
2-cyclopentyl-2-phenyl-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
-
23
2-methyltetrahydro-2H-pyran-3,4-diol
-
uncompetitive inhibition
0.0000117
2-phenyl-N-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl)methyl)quinoline-4-carboxamide
-
22 - 83
2-phenyl-tetrahydro-2H-pyran-3,4-diol
-
uncompetitive inhibition, depending on conformation
0.0000056
3-(1H-indol-3-yl)-N-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl)methyl)propanamide
-
0.000105
3-(1H-indol-3-yl)-N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide
-
-
1.25
4-aminophenyl 1-thio alpha-L-fucoside
-
weak competitive inhibition
0.09
4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate
-
competitive inhibition
0.91
5-(hydroxymethyl)pyrrolidine-2,3,4-triol
-
competitive inhibition
0.000001
5-amino-5-deoxy-L-fucose
-
-
0.0000097
5-fluoro-N-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl)methyl)-1H-indole-2-carboxamide
-
0.055
6-N-acetylamino-deoxymannojirimycin
-
pH 4, 60°C
0.57 - 28
alpha-L-fuco N-benzyl aminocyclopentitol
0.3 - 180
alpha-L-fuco-N-benzyl aminocyclopentitol
0.2
alpha-L-fucose
pH 5.5, 37°C
0.03
D-1-deoxymannojirimycin
-
competitive inhibition
0.011
D-1-deoxyrhamnojirimycin
-
competitive inhibition
0.053
D-1-deoxytalonojirimycin
-
competitive inhibition
35
D-fucal
-
uncompetitive inhibition
0.000024
deoxyfuconojirimycin
-
competitive inhibition
0.15
fucose
-
pH 6.5, 37°C
0.014
fucosylamine
-
competitive inhibition
0.00003
L-1-deoxyfuconojirimycin
-
competitive inhibition
90
L-1-deoxymannojirimycin
-
competitive inhibition
1
L-1-deoxyrhamnojirimycin
-
competitive inhibition
0.05
L-fucal
-
competitive inhibition, best inhibitor of glycal compounds tested
0.000001
L-fuco-nojirimycin
-
-
0.316
L-fucosamine
-
pH 4, 60°C
0.24 - 1.09
L-fucose
140
L-rhamnose
-
competitive inhibition
0.000441
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide
-
-
0.000427
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-3-carboxamide
-
-
0.0045
N-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
-
0.64
p-nitrophenyl alpha-L-fucoside
pH 5.0, 60°C
112
phenol
-
noncompetitive inhibition
12.2
Tris(hydroxymethyl)aminomethane
pH 5.5, 37°C