3.2.1.50: alpha-N-acetylglucosaminidase
This is an abbreviated version!
For detailed information about alpha-N-acetylglucosaminidase, go to the full flat file.
Word Map on EC 3.2.1.50
-
3.2.1.50
-
oligosaccharide
-
glycoside
-
lysosomal
-
glycans
-
n-linked
-
lectin
-
beta-glucosidase
-
sialic
-
neuraminidase
-
glycoconjugates
-
n-acetylglucosamine
-
iminosugars
-
glycopeptides
-
sialylated
-
glcnac
-
alpha-l-fucosidase
-
mucopolysaccharidosis
-
sialidase
-
anomeric
-
polyhydroxylated
-
swainsonine
-
mannosidase
-
1-deoxynojirimycin
-
asparagine-linked
-
fucosylated
-
high-mannose
-
beta-n-acetylglucosaminidase
-
beta-d-galactosidase
-
naglu
-
complex-type
-
alpha-d-mannosidase
-
1-deoxymannojirimycin
-
fucosidase
-
alpha-d-galactosidase
-
n-acetyl-beta-d-glucosaminidase
-
almond
-
transglycosylation
-
pngase
-
hydrazinolysis
-
castanospermine
-
sulfonium
-
alpha-n-acetylgalactosaminidase
-
beta-d-xylosidase
-
neuac
-
mannose-type
-
triantennary
-
endo-beta-galactosidase
-
beta-mannosidase
-
alpha-d-glucosidase
-
alpha-l-iduronidase
-
medicine
- 3.2.1.50
- oligosaccharide
- glycoside
- lysosomal
- glycans
-
n-linked
- lectin
- beta-glucosidase
-
sialic
- neuraminidase
- glycoconjugates
- n-acetylglucosamine
-
iminosugars
- glycopeptides
-
sialylated
- glcnac
- alpha-l-fucosidase
- mucopolysaccharidosis
- sialidase
-
anomeric
-
polyhydroxylated
- swainsonine
-
mannosidase
- 1-deoxynojirimycin
-
asparagine-linked
-
fucosylated
-
high-mannose
- beta-n-acetylglucosaminidase
- beta-d-galactosidase
- naglu
-
complex-type
- alpha-d-mannosidase
- 1-deoxymannojirimycin
-
fucosidase
- alpha-d-galactosidase
-
n-acetyl-beta-d-glucosaminidase
- almond
-
transglycosylation
-
pngase
-
hydrazinolysis
- castanospermine
-
sulfonium
- alpha-n-acetylgalactosaminidase
- beta-d-xylosidase
- neuac
-
mannose-type
-
triantennary
- endo-beta-galactosidase
- beta-mannosidase
- alpha-d-glucosidase
- alpha-l-iduronidase
- medicine
Reaction
Synonyms
2-acetamido-2-deoxy-alpha-D-glucoside acetamidodeoxyglucohydrolase, AgnB, AgnC, alpha-acetylglucosaminidase, alpha-N-acetylglucosaminidase, BMN 250, exo-glycosidase, glycosidase, heparan N-sulfatase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, NAGase, NAGLU, Sanfilippo b corrective factor
ECTree
3.2.1.50 alpha-N-acetylglucosaminidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.2.1.50 - alpha-N-acetylglucosaminidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
2,4-dinitrophenyl-alpha-N-acetyl-D-glucosaminide + H2O
2,4-dinitrophenol + N-acetyl-D-glucosamine
25°C
-
-
?
2-nitrophenyl alpha-N-acetylglucosaminide + H2O
2-nitrophenol + alpha-N-acetylglucosamine
-
-
-
-
?
4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O
?
-
-
-
?
4-methylumbelliferyl 4-O-N-acetyl-alpha-D-glucosaminyl-beta-D-galactoside + H2O
N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-galactosaminide
-
-
-
-
?
4-methylumbelliferyl 6-O-N-acetyl-alpha-D-glucosaminyl-beta-D-galactoside + H2O
N-acetyl-alpha-D-glucosamine + 4-methylumbelliferyl beta-D-galactosaminide
-
slow reaction
-
-
?
4-methylumbelliferyl N-acetyl-alpha-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-alpha-D-glucosamine
4-methylumbelliferyl-2-acetamide-2-deoxy-alpha-D-glucopyranoside + H2O
4-methylumbelliferol + 2-acetamide-2-deoxy-alpha-D-glucopyranose
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-alpha-D-glucosamine
-
slow reaction
-
-
?
4-nitrophenyl-alpha-N-acetyl-D-glucosaminide + H2O
4-nitrophenol + N-acetyl-alpha-D-glucose
25°C
-
-
?
4-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
N-acetyl-alpha-D-glucosamine + 4-nitrophenol
methylumbelliferyl-N-acetyl-alpha-D-glucosaminide + H2O
methylumbelliferone + N-acetyl-alpha-D-glucosamine
methylumbelliferyl-N-acetylglucosamine + H2O
methylumbelliferone + N-acetylglucosamine
-
-
-
?
methylumbelliferyl-N-acetylglucosamine-6-sulfate + H2O
methylumbelliferone + N-acetylglucosamine-6-sulfate
-
-
-
?
N-acetyl-alpha-D-Gluc-1,4-(1-methoxyphenyl)Gal + H2O
N-acetyl-alpha-D-glucosamine + 1-methoxyphenyl-Gal
O-(alpha-acetamido-2-deoxy-D-glucopyranosyl)-(1-3)-[L-6,3H]idoronic acid + H2O
?
-
-
-
?
o-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-glucosamine
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
UDP-N-acetyl-alpha-D-glucosamine + H2O
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
uridine-5'-diphospho-N-acetyl-alpha-D-glucosamine
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
involved in the degradation of heparin and heparan sulfate
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
involved in the degradation of heparin and heparan sulfate
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
involved in the degradation of heparin and heparan sulfate
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
involved in the degradation of heparin and heparan sulfate
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
involved in the degradation of heparin and heparan sulfate
-
-
?
(GlcNAcalpha(1-4))n + H2O
(GlcNAcalpha(1-4))n-1 + 2-(acetylamino)-2-deoxy-beta-D-glucopyranose
-
-
-
?
4-methylumbelliferyl N-acetyl-alpha-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-alpha-D-glucosamine
-
efficient substrate
-
-
?
4-methylumbelliferyl N-acetyl-alpha-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-alpha-D-glucosamine
-
-
-
?
4-methylumbelliferyl N-acetyl-alpha-D-glucosaminide + H2O
4-methylumbelliferone + N-acetyl-alpha-D-glucosamine
-
-
-
-
?
4-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
N-acetyl-alpha-D-glucosamine + 4-nitrophenol
-
-
-
?
4-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
N-acetyl-alpha-D-glucosamine + 4-nitrophenol
-
-
-
?
cell surface mucin + H2O
N-acetyl-alpha-D-glucosamine + ?
-
-
-
?
cell surface mucin + H2O
N-acetyl-alpha-D-glucosamine + ?
-
-
-
?
methylumbelliferyl-N-acetyl-alpha-D-glucosaminide + H2O
methylumbelliferone + N-acetyl-alpha-D-glucosamine
-
-
-
?
methylumbelliferyl-N-acetyl-alpha-D-glucosaminide + H2O
methylumbelliferone + N-acetyl-alpha-D-glucosamine
-
-
-
?
N-acetyl-alpha-D-Gluc-1,4-(1-methoxyphenyl)Gal + H2O
N-acetyl-alpha-D-glucosamine + 1-methoxyphenyl-Gal
-
-
-
?
N-acetyl-alpha-D-Gluc-1,4-(1-methoxyphenyl)Gal + H2O
N-acetyl-alpha-D-glucosamine + 1-methoxyphenyl-Gal
-
-
-
?
o-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
o-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
o-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-glucosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
phenyl-N-acetyl-alpha-D-glucosaminide + H2O
phenol + N-acetyl-alpha-D-glucosamine
-
-
-
?
porcine gastric mucin + H2O
N-acetyl-alpha-D-glucosamine + ?
-
the enzyme specifically hydrolyzes alpha-linked N-acetylglucosamine at nonreducing terminus of O-glycan on gastric mucin
-
-
?
porcine gastric mucin + H2O
N-acetyl-alpha-D-glucosamine + ?
-
-
-
?
porcine gastric mucin + H2O
N-acetyl-alpha-D-glucosamine + ?
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
-
?
uridine-5'-diphospho-N-acetyl-alpha-D-glucosamine
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
?
uridine-5'-diphospho-N-acetyl-alpha-D-glucosamine
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
?
uridine-5'-diphospho-N-acetyl-alpha-D-glucosamine
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
?
uridine-5'-diphospho-N-acetyl-alpha-D-glucosamine
uridine-5'-diphosphate + N-acetyl-alpha-D-glucosamine
-
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl N-acetyl-beta-D-glucosaminide, 4-nitrophenyl N-acetyl-alpha-D-galactosaminide, 4-nitrophenyl N-acetyl-beta-D-galactosaminide, 4-nitrophenyl alpha-D-glucosaminide, 4-nitrophenyl beta-D-glucosaminide, 4-nitrophenyl alpha-D-galactosaminide, 4-nitrophenyl beta-D-galactosaminide, 4-nitrophenyl alpha-D-fucosaminide, 4-nitrophenyl beta-D-fucosaminide, 4-nitrophenyl alpha-D-mannosaminide, 4-nitrophenyl beta-D-mannosaminide, 4-nitrophenyl alpha-D-xylosaminide, and 4-nitrophenyl beta-D-xylosaminide. Alpha1,2- and alpha1,3-linked N-acetyl-alpha-D-glucosaminides are resistant to this enzyme
-
-
?
additional information
?
-
-
swollen chitin and oligosaccharide above (GlcNAc)4 are not hydrolyzed by the enzyme
-
?
additional information
?
-
no activity against any of the GlcNAc1,2-(1-methoxyphenyl)Gal, GlcNAc-1,3-(1-methoxyphenyl)Gal, GlcNAc-1,6-(1-methoxyphenyl)Gal, andGlcNAc-1,4-(1-methoxyphenyl)Glc substrates
-
-
?
additional information
?
-
-
no activity against any of the GlcNAc1,2-(1-methoxyphenyl)Gal, GlcNAc-1,3-(1-methoxyphenyl)Gal, GlcNAc-1,6-(1-methoxyphenyl)Gal, andGlcNAc-1,4-(1-methoxyphenyl)Glc substrates
-
-
?
additional information
?
-
no activity against any of the GlcNAc1,2-(1-methoxyphenyl)Gal, GlcNAc-1,3-(1-methoxyphenyl)Gal, GlcNAc-1,6-(1-methoxyphenyl)Gal, andGlcNAc-1,4-(1-methoxyphenyl)Glc substrates
-
-
?
additional information
?
-
-
mucopolysaccharidosis type IIIB is a lysosomal storage disorder characterized by the defective degradation of heparan sulfate due to a deficiency of alpha-N-acetylglucosaminidase. The clinical severity of mucopolysacchariddosis type IIIB ranges from an attenuated to severely affected Sanfilippo phenotype. Relationship between genotype, cellular biochemistry and clinical phenotype in a F48L/R297X compound heterozygous mucopolysaccharidosis type IIIB patient with an attenuated Sanfilippo phenotype
-
?
additional information
?
-
-
enzyme deficiency causes the Sanfilippo type B syndrome, i.e. the mucopolysaccharidosis type IIIB, a lysosomal storage disorder, phenotype, overview
-
-
?
additional information
?
-
-
enzyme deficiency causes the Sanfilippo type B syndrome, i.e. the mucopolysaccharidosis type IIIB, an autosomal recessive lysosomal storage disorder, overview
-
-
?
