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3.2.1.50: alpha-N-acetylglucosaminidase

This is an abbreviated version!
For detailed information about alpha-N-acetylglucosaminidase, go to the full flat file.

Word Map on EC 3.2.1.50

Reaction

(GlcNAcalpha(1-4))n
+
H2O
=
(GlcNAcalpha(1-4))n-1
 +
2-(acetylamino)-2-deoxy-beta-D-glucopyranose

Synonyms

2-acetamido-2-deoxy-alpha-D-glucoside acetamidodeoxyglucohydrolase, AgnB, AgnC, alpha-acetylglucosaminidase, alpha-N-acetylglucosaminidase, BMN 250, exo-glycosidase, glycosidase, heparan N-sulfatase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, NAGase, NAGLU, Sanfilippo b corrective factor

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.50 alpha-N-acetylglucosaminidase

Specific Activity

Specific Activity on EC 3.2.1.50 - alpha-N-acetylglucosaminidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000009
-
methylumbelliferyl-N-acetyl-alpha-D-glucosaminide as substrate
0.00012
-
phenyl-N-acetyl-alpha-D-glucosaminide as substrate
0.00015 - 0.0003
-
homogenates of various organes
0.001
0.00117
-
mutant with genotype R643C/R533X
0.0012
-
in lysosomes
0.0017
-
mutant with genotype R234C/R234C
0.0025
-
mutant with genotype R234C/R234C
0.0027
-
mutant with genotype R234C/M1K
0.003
-
mutant with genotype R565W/R565W
0.00317
-
mutant with genotype R565W/R565W
0.0075
-
purified enzyme
0.027
-
partially purified enzyme
0.115 - 1.2
-
purified enzyme, p-nitrophenyl-N-acetyl-alpha-D-glucosaminide as substrate
0.2
wild-type, substrate N-acetyl-alpha-D-Gluc-1,4-(1-methoxyphenyl)Gal, pH 7.4, 37°C
0.58
-
purified enzyme, methylumbelliferyl-N-acetyl-alpha-D-glucosaminide as substrate
1.057
-
-
1.35
-
purified enzyme
2.82
C-terminal deletion mutant, substrate N-acetyl-alpha-D-Gluc-1,4-(1-methoxyphenyl)Gal, pH 7.4, 37°C
additional information