3.2.1.50: alpha-N-acetylglucosaminidase
This is an abbreviated version!
For detailed information about alpha-N-acetylglucosaminidase, go to the full flat file.
Word Map on EC 3.2.1.50
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3.2.1.50
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oligosaccharide
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glycoside
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lysosomal
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glycans
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n-linked
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lectin
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beta-glucosidase
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sialic
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neuraminidase
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glycoconjugates
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n-acetylglucosamine
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iminosugars
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glycopeptides
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sialylated
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glcnac
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alpha-l-fucosidase
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mucopolysaccharidosis
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sialidase
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anomeric
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polyhydroxylated
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swainsonine
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mannosidase
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1-deoxynojirimycin
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asparagine-linked
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fucosylated
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high-mannose
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beta-n-acetylglucosaminidase
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beta-d-galactosidase
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naglu
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complex-type
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alpha-d-mannosidase
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1-deoxymannojirimycin
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fucosidase
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alpha-d-galactosidase
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n-acetyl-beta-d-glucosaminidase
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almond
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transglycosylation
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pngase
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hydrazinolysis
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castanospermine
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sulfonium
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alpha-n-acetylgalactosaminidase
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beta-d-xylosidase
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neuac
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mannose-type
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triantennary
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endo-beta-galactosidase
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beta-mannosidase
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alpha-d-glucosidase
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alpha-l-iduronidase
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medicine
- 3.2.1.50
- oligosaccharide
- glycoside
- lysosomal
- glycans
-
n-linked
- lectin
- beta-glucosidase
-
sialic
- neuraminidase
- glycoconjugates
- n-acetylglucosamine
-
iminosugars
- glycopeptides
-
sialylated
- glcnac
- alpha-l-fucosidase
- mucopolysaccharidosis
- sialidase
-
anomeric
-
polyhydroxylated
- swainsonine
-
mannosidase
- 1-deoxynojirimycin
-
asparagine-linked
-
fucosylated
-
high-mannose
- beta-n-acetylglucosaminidase
- beta-d-galactosidase
- naglu
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complex-type
- alpha-d-mannosidase
- 1-deoxymannojirimycin
-
fucosidase
- alpha-d-galactosidase
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n-acetyl-beta-d-glucosaminidase
- almond
-
transglycosylation
-
pngase
-
hydrazinolysis
- castanospermine
-
sulfonium
- alpha-n-acetylgalactosaminidase
- beta-d-xylosidase
- neuac
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mannose-type
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triantennary
- endo-beta-galactosidase
- beta-mannosidase
- alpha-d-glucosidase
- alpha-l-iduronidase
- medicine
Reaction
Synonyms
2-acetamido-2-deoxy-alpha-D-glucoside acetamidodeoxyglucohydrolase, AgnB, AgnC, alpha-acetylglucosaminidase, alpha-N-acetylglucosaminidase, BMN 250, exo-glycosidase, glycosidase, heparan N-sulfatase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, NAGase, NAGLU, Sanfilippo b corrective factor
ECTree
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Engineering
Engineering on EC 3.2.1.50 - alpha-N-acetylglucosaminidase
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E601A
mutation in the active site, lack of enzymatic activity
mutagenesis of Glu-483
mutation in the active site, less enzymatic activity
R565P
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naturally occurring mutation, five patients with the homozygous mutation in the alpha-N-acetylglucosaminidase gene from the Okinawa islands in Japan show the Sanfilippo type B syndrome, heterozygotes show no phenotype
additional information
deletion of the C-terminal region containing several carbohydrate-binding module 32 domains significantly reduces the activity for porcine gastric mucin,while activity against GlcNAc1,4-(1-methoxyphenyl)Gal is markedly enhanced. A deletion construct containing the C-terminal carbohydrate-binding module-C2 to carbohydrate-binding module-C6 domains binds strongly to porcine gastric mucin
additional information
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deletion of the C-terminal region containing several carbohydrate-binding module 32 domains significantly reduces the activity for porcine gastric mucin,while activity against GlcNAc1,4-(1-methoxyphenyl)Gal is markedly enhanced. A deletion construct containing the C-terminal carbohydrate-binding module-C2 to carbohydrate-binding module-C6 domains binds strongly to porcine gastric mucin
additional information
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deletion of the C-terminal region containing several carbohydrate-binding module 32 domains significantly reduces the activity for porcine gastric mucin,while activity against GlcNAc1,4-(1-methoxyphenyl)Gal is markedly enhanced. A deletion construct containing the C-terminal carbohydrate-binding module-C2 to carbohydrate-binding module-C6 domains binds strongly to porcine gastric mucin
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additional information
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NAGLU-encoding gene: geneotyping and identification of a large homozygous intragenic deletion mutation in the alpha-N-acetylglucosaminidase gene, causing enzyme deficiency, involved in the autosomal recessive disease Sanfilippo type B syndrome, i.e. mucopolysaccharidosis IIIB, in a Turkish patient, phenotype,overview
additional information
expression of human NaGlu in the central nervous system of mucopolysaccharidosis IIIB mice by an i.c. injection approach
additional information
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expression of human NaGlu in the central nervous system of mucopolysaccharidosis IIIB mice by an i.c. injection approach