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3.2.1.50: alpha-N-acetylglucosaminidase

This is an abbreviated version!
For detailed information about alpha-N-acetylglucosaminidase, go to the full flat file.

Word Map on EC 3.2.1.50

Reaction

(GlcNAcalpha(1-4))n
+
H2O
=
(GlcNAcalpha(1-4))n-1
+
2-(acetylamino)-2-deoxy-beta-D-glucopyranose

Synonyms

2-acetamido-2-deoxy-alpha-D-glucoside acetamidodeoxyglucohydrolase, AgnB, AgnC, alpha-acetylglucosaminidase, alpha-N-acetylglucosaminidase, BMN 250, exo-glycosidase, glycosidase, heparan N-sulfatase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, NAGase, NAGLU, Sanfilippo b corrective factor

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.50 alpha-N-acetylglucosaminidase

Cloned

Cloned on EC 3.2.1.50 - alpha-N-acetylglucosaminidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination of Sanfilippo type B syndrome patients
-
expressed in Chinese hamster ovary cells
-
expressed in CHO cells
expressed in Escherichia coli BL21(lambdaDE3) cells
-
expression in CHO-K1 cells
-
expression in Escherichia coli
expression of active alpha-N-acetylglucosaminidase/TAT chimerae in cultured Spodoptera frugiperda cells, establishment of an expression method for optimization of scale-up
-
NAGLU-encoding gene, located on chromosome 17q21.1, DNA and amino acid sequence determination and analysis, genotyping
-
R297X and F48L mutant alleles are engineered into the wild-type alpha-N-acetylglucosaminidase and expressed in Chinese hamster ovary cells. Wild-type enzyme and F48L mutant alleles are retrovirally expressed in mucopolysaccharidosis type IIIB skin fibroblasts
-