3.2.1.48: sucrose alpha-glucosidase

This is an abbreviated version!
For detailed information about sucrose alpha-glucosidase, go to the full flat file.

Word Map on EC 3.2.1.48

3.2.1.48

border

brush

lactase

enterocytes

disaccharidase

caco-2

mucosal

crypt

jejunal

starch

maltase-glucoamylase

brush-border

glucoamylase

maltose

lactase-phlorizin

ileum

trehalase

microvillus

acarbose

basolateral

postprandial

dipeptidyl

villin

suckling

dipeptidylpeptidase

malabsorption

goblet

3.2.1.20

enterocyte-like

isomaltose

3.4.11.2

intestine-specific

carbohydrase

small-intestinal

aminopeptidase-n

postconfluent

crypt-villus

paneth

1-deoxynojirimycin

bloating

dextrin

agriculture

medicine

Reaction

= 2 D-glucose

Synonyms

alpha-glucosidase, glucosidase, sucrose alpha-, intestinal sucrase, isomaltase, More, PF0132, pro-SI, SI, sucrase, sucrase isomaltase, sucrase-invertase, sucrase-isomaltase, sucrase-isomaltase enzyme complex, sucrase/isomaltase, sucrose alpha-glucohydrolase, sucrose hydrolase, SUH

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.48 sucrose alpha-glucosidase

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Results	in table
6	Activating Compound
26	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
3	Crystallization (Commentary)
676	Disease/ Diagnostics
11	General Information
9	IC50 Value
62	Inhibitors
4	kcat/KM [mM/s]
5	Ki Value [mM]
57	KM Value [mM]
24	Localization
6	Metals/Ions
26	Molecular Weight [Da]
78	Natural Substrates/ Products (Substrates)
67	Organism
7	Pathway
4	PDB ID
18	pH Optimum
7	pH Range
1	pI Value
2	Posttranslational Modification
39	Protein Variants
18	Purification (Commentary)
3	Reaction
1	Reaction Type
66	Reference
36	Source Tissue
18	Specific Activity [micromol/min/mg]
3	Storage Stability
135	Substrates and Products (Substrate)
13	Subunits
40	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
15	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.2.1.48 - sucrose alpha-glucosidase

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112000

Platyrrhini

1 * 112000 + 1* 100000, hetero-dimer, 2 catalytically active sites for maltase and sucrase

136516

130000

Homo sapiens

gel filtration, density gradient, equilibrium centrifugation, sucrase subunit

136505, 136520

140000

4 entries

145000

Homo sapiens

1 * 145000, sucrase + 1* 151000, isomaltase

136517

150000

Sus scrofa

SDS-PAGE, intact pancreatic duct, subunit II

200000

210000

x * 210000, about

220000

245000

fully glycosylated enzyme in the Golgi apparatus

260000

270000

SDS-PAGE

280000

290000

gel filtration, sucrase-isomaltase complex, intestinal mucosa

136498

380000

Anser anser

380000 sucrase + 543000 isomaltase, enzyme complex after solubilisation by emulphogen and papain

136512

64000

Xanthomonas axonopodis

Q6UVM5

1 * 64000, SDS-PAGE

655879

99320

Actinomyces naeslundii

gene coding sucrase cloned in pPNG102 contains a ORF which defines a polypeptide of 99319 Da, the sequence shows similarity to previously sequenced sucrose-hydrolyzing enzymes

136519

additional information

Homo sapiens

The enzyme complex is a pseudo-dimeric assembly of a correctly folded and an enzymatically active pro-SI. The sucrase subunit functions as an intramolecular chaperone implicated in the folding of isomaltase subunit. After acquisition of a correct folding in the sucrase subunit this mature form binds tightly to the isomaltase, disrupting its interaction with calnexin. The consequence is that the isomaltase subunit acquires correct folding and sucrase subunit is no longer secreted into the external milieu.

656071