3.2.1.46: galactosylceramidase

This is an abbreviated version!
For detailed information about galactosylceramidase, go to the full flat file.

Reaction

Synonyms

beta-galactocerebrosidase, beta-galactosylceramidase, ceramidase, galacatosyl-, ceramide galactosidase, cerebroside beta-galactosidase, cerebroside galactosidase, galactoceramidase, galactocerebrosidase, galactocerebroside beta-galactosidase, galactocerebroside galactosidase, galactocerebroside-beta-D-galactosidase, Galactosylceramidase, galactosylceramidase I, galactosylceramide beta-galactosidase, galactosylcerebrosidase, GALC, galcerase, GM1 ganglioside beta-galactosidase, lactosylceramidase, lactosylceramidase I

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.46 galactosylceramidase

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Results	in table
15	Activating Compound
2042	AA Sequence
23	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
1040	Disease/ Diagnostics
8	General Information
2	General Stability
22	Inhibitors
15	KM Value [mM]
9	Localization
1	Metals/Ions
19	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
39	Organism
2	Pathway
15	PDB ID
15	pH Optimum
5	pH Range
1	Posttranslational Modification
9	Protein Variants
11	Purification (Commentary)
1	Reaction
5	Reaction Type
38	Reference
55	Source Tissue
20	Specific Activity [micromol/min/mg]
99	Substrates and Products (Substrate)
4	Subunits
29	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.2.1.46 - galactosylceramidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-methylumbelliferyl beta-galactoside + H2O

methylumbelliferone + beta-D-galactose

2 entries

4-methylumbelliferyl-beta-D-galactopyranoside + H2O

4-methylumbelliferone + beta-D-galactopyranose

2 entries

5-bromo-3-chloro-beta-galactopyranoside + H2O

?

Mus musculus

-

-

652984

-

652984

?

6-hexadecanoylamino-4-methylumbelliferyl-beta-D-galactopyranoside + H2O

6-hexadecanoylamino-4-methylumbelliferone + beta-D-galactopyranose

3 entries

D-galactosyl-alkyl-acyl-glycerol + H2O

?

Mus musculus

-

a precursor of the seminolipid

664853

-

-

?

D-galactosyl-N-acylsphingosine + H2O

?

4 entries

D-galactosyl-N-acylsphingosine + H2O

D-galactose + N-acylsphingosine

4 entries

D-galactosylceramide + H2O

D-galactose + ceramide

Mus musculus

-

-

664853

-

-

?

D-galactosylsphingoside + H2O

D-galactose + sphingosine

Mus musculus

-

i.e. psychosine

664853

-

-

?

galactocerebroside + H2O

D-galactose + N-acylceramide

4 entries

galactosylceramide + H2O

D-galactose + N-acylceramide

3 entries

GM1 ganglioside + H2O

D-galactose + N-acylceramide

2 entries

lactosylsphingosine + H2O

lactose + sphingosine

2 entries

N-stearoyl psychosine + H2O

D-galactose + N-stearoylsphingosine

Rattus norvegicus

-

-

171513

-

-

?

psychosine + H2O

D-galactose + sphingosine

2 entries

additional information

?

-

Mus musculus

-

the enzyme is required for normal sperm maturation and function, enzyme deficiency leads to degeneration of oligodendrocytes, severe demyelination, and causes sperm abnormalities in the mouse model of human globoid cell leukodystrophy or Krabbe disease, mutant twitcher mice show reduced size of testis and sperm acrosomal membrane which is redundant, detached from the nucleus and folded over

664853

-

-

?

4-methylumbelliferyl beta-galactoside + H2O

methylumbelliferone + beta-D-galactose

Homo sapiens

-

-

171510, 171512, 171514, 171515, 171516, 171518

-

-

?

4-methylumbelliferyl beta-galactoside + H2O

methylumbelliferone + beta-D-galactose

Mus musculus

-

-

171514

-

-

?

4-methylumbelliferyl-beta-D-galactopyranoside + H2O

4-methylumbelliferone + beta-D-galactopyranose

Homo sapiens

-

pH 4.0, 30 min, 37°C

697390

-

-

?

4-methylumbelliferyl-beta-D-galactopyranoside + H2O

4-methylumbelliferone + beta-D-galactopyranose

Mus musculus

-

pH 4.0, 30 min, 37°C

697390

-

-

?

6-hexadecanoylamino-4-methylumbelliferyl-beta-D-galactopyranoside + H2O

6-hexadecanoylamino-4-methylumbelliferone + beta-D-galactopyranose

Homo sapiens

-

-

171519

-

-

?

6-hexadecanoylamino-4-methylumbelliferyl-beta-D-galactopyranoside + H2O

6-hexadecanoylamino-4-methylumbelliferone + beta-D-galactopyranose

Homo sapiens

-

fluorogenic substrate

171517

-

-

?

6-hexadecanoylamino-4-methylumbelliferyl-beta-D-galactopyranoside + H2O

6-hexadecanoylamino-4-methylumbelliferone + beta-D-galactopyranose

Mus musculus

-

fluorogenic substrate

171517

-

-

?

D-galactosyl-N-acylsphingosine + H2O

?

Homo sapiens

-

-

171506, 171507, 171508, 171509, 171510, 171511, 171512, 171514, 171515, 171516, 171517, 171518, 171519, 171522

-

-

?

D-galactosyl-N-acylsphingosine + H2O

?

Macaca mulatta

O02791

-

171521

-

-

?

D-galactosyl-N-acylsphingosine + H2O

?

Mus musculus

-

-

171507, 171514, 171517

-

-

?

D-galactosyl-N-acylsphingosine + H2O

?

Rattus norvegicus

-

-

171509, 171513

-

-

?

D-galactosyl-N-acylsphingosine + H2O

D-galactose + N-acylsphingosine

Homo sapiens

-

-

171506, 171507, 171508, 171509, 171510, 171511, 171512, 171514, 171515, 171516, 171517, 171518, 171519, 171522

-

-

?

D-galactosyl-N-acylsphingosine + H2O

D-galactose + N-acylsphingosine

Macaca mulatta

O02791

-

171521

-

-

?

D-galactosyl-N-acylsphingosine + H2O

D-galactose + N-acylsphingosine

Mus musculus

-

-

171507, 171514, 171517, 683453, 683796

-

-

?

D-galactosyl-N-acylsphingosine + H2O

D-galactose + N-acylsphingosine

Rattus norvegicus

-

-

171509, 171513

-

-

?

galactocerebroside + H2O

D-galactose + N-acylceramide

Homo sapiens

-

-

171506, 171507, 171508, 171509, 171510, 171511, 171512, 171514, 171515, 171516, 171517, 171518, 171519, 171522

-

-

?

galactocerebroside + H2O

D-galactose + N-acylceramide

Macaca mulatta

O02791

-

171521

-

-

?

galactocerebroside + H2O

D-galactose + N-acylceramide

Mus musculus

-

-

171507, 171514, 171517

-

-

?

galactocerebroside + H2O

D-galactose + N-acylceramide

Rattus norvegicus

-

-

171509, 171513

-

-

?

galactosylceramide + H2O

D-galactose + N-acylceramide

Homo sapiens

-

-

171511, 171512, 171514, 171518, 171519, 171522

-

-

?

galactosylceramide + H2O

D-galactose + N-acylceramide

Macaca mulatta

O02791

-

171521

-

-

?

galactosylceramide + H2O

D-galactose + N-acylceramide

Mus musculus

-

-

171514

-

-

?

GM1 ganglioside + H2O

D-galactose + N-acylceramide

Homo sapiens

-

-

171514, 171519

-

-

?

GM1 ganglioside + H2O

D-galactose + N-acylceramide

Mus musculus

-

-

171514

-

-

?

lactosylsphingosine + H2O

lactose + sphingosine

Homo sapiens

-

-

171506, 171512, 171514

-

-

?

lactosylsphingosine + H2O

lactose + sphingosine

Mus musculus

-

-

171514

-

-

?

psychosine + H2O

D-galactose + sphingosine

Homo sapiens

-

-

171506, 171518

-

-

?

psychosine + H2O

D-galactose + sphingosine

Mus musculus

-

galactosylsphingosine

683453, 683796

-

-

?