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3.2.1.36: hyaluronoglucuronidase

This is an abbreviated version!
For detailed information about hyaluronoglucuronidase, go to the full flat file.

Word Map on EC 3.2.1.36

Reaction

hyaluronic acid hexasaccharide
+
H2O
=
GlcAbeta(1-3)GlcNAcbeta(1-4)GlcA
+
GlcNAcbeta(1-4)GlcAbeta(1-3)GlcNAc

Synonyms

glucuronoglucosaminoglucan hyaluronate lyase, HAase, HAase-B, hyaluronate lyase HylP2, hyaluronate lyase HylP3, hyaluronidase, HYase, LHase, orgelase, VesT2a, VesT2b

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.36 hyaluronoglucuronidase

Substrates Products

Substrates Products on EC 3.2.1.36 - hyaluronoglucuronidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
chondroitin sulfate A + H2O
?
show the reaction diagram
chondroitin sulfate A + H2O
oligosaccharides + ?
show the reaction diagram
chondroitin sulfate C + H2O
?
show the reaction diagram
chondroitin sulfate D + H2O
?
show the reaction diagram
dermatan sulfate + H2O
?
show the reaction diagram
-
chondroitin sulfate B, low activity
-
-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
show the reaction diagram
hyaluronan + H2O
?
show the reaction diagram
hyaluronan + H2O
hyaluronan tetrasaccharides + hyaluronan hexasaccharides
show the reaction diagram
hyaluronan is mainly degraded into hyaluronan tetrasaccharides and hyaluronan hexasaccharides. The proportion of hyaluronan tetrasaccharides and hyaluronan hexasaccharides is accurately controlled by amount of enzyme. Higher yield of hyaluronan tetrasaccharides is achieved with higher activity of the enzyme
-
-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
show the reaction diagram
hyaluronic acid + H2O
?
show the reaction diagram
hyaluronic acid + H2O
hyaluronic acid oligomers
show the reaction diagram
additional information
?
-