3.2.1.33: amylo-alpha-1,6-glucosidase
This is an abbreviated version!
For detailed information about amylo-alpha-1,6-glucosidase, go to the full flat file.
Word Map on EC 3.2.1.33
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3.2.1.33
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glycogenosis
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myopathy
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hepatomegaly
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maltase
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gsd-iii
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maltotetraosyl
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maltooligosaccharide
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maltotriosyl
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medicine
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synthesis
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nutrition
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analysis
- 3.2.1.33
- glycogenosis
- myopathy
- hepatomegaly
- maltase
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gsd-iii
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maltotetraosyl
- maltooligosaccharide
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maltotriosyl
- medicine
- synthesis
- nutrition
- analysis
Reaction
Synonyms
1,4-glucan-4-glucosyltransferase/amylo-1,6-glucosidase, 4-alpha-glucano-transferase amylo-1,6-glucosidase, alpha-(1,6)-glucosidase, alpha-1,6-glucosidase, amylo-1,6-glucosidase, amylo-1,6-glucosidase-oligo-1,4-1,4-transferase, amylo-1,6-glucosidase/1,4-alpha-glucan 4-alpha-glucan 4-alpha-glycosyltransferase, amylo-1,6-glucosidase/1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glycosyltransferase, amylo-1,6-glucosidase/4-alpha-glucanotransferase, amylo-1,6-glucosidase/oligo-1,4-1,4-glucantransferase, amylo-alpha-1,6-glucosidase, amylo-alpha-1,6-glucosidase activity, amyloglucosidase, amylopectin 1,6-glucosidase, debrancher enzyme, debrancher protein, dextrin 6-alpha-D-glucosidase, dextrin 6-alpha-glucosidase, dextrin 6-glucanohydrolase, dextrin 6-glucohydrolase, dextrin-1,6-glucosidase, dextrin:6-glucohydrolase, GDE, GDE amylo-alpha-1,6-glucosidase, glucosidase, amylo-1,6-, glucosidase/transferase, glycogen debranching enzyme, glycogen debranching system, glycogen phosphorylase dextrin 6-glucanohydrolase, glycogen phosphorylase limit dextrin alpha-1,6-glucohydrolase, glycogen phosphorylase limit dextrin debranching system, indirect debranching enzyme, NPDE, oligo-alpha-1,4-glucan:alpha-1,4-glucan-4-glycosyltransferase-amylo-1,6-glucosidase, SSO2094, transferase-glucosidase, TreX
ECTree
3.2.1.33 amylo-alpha-1,6-glucosidaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.2.1.33 - amylo-alpha-1,6-glucosidase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1,4-diaminobutane
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putrescine, glycogen debranching enzyme, slight inhibition
2-(2-hydroxyethylamino)-2-hydroxymethyl-1,3-propanediol
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hydroxyethyltris
2-deoxy-2-fluoro-alpha-glucosyl fluoride
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very poor inhibitor, 56 mM: 17% inhibition
2-hydroxyethyl-3-hydroxypropylamine
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HEPA, glycogen debranching enzyme
5-amino-D-glucose
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nojirimycin, potent inhibitor, noncompetitive
cyclohexaamylose
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alpha-Schardinger dextrin, debranching enzyme, competitive inhibitor
D-glucono-1,5-lactone
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glycogen debranching enzyme, noncompetitive with glycogen phosphorylase limit dextrin, competitive with glucose
glucooligosaccharides
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containing one, two, or three glucose, competitive inhibitors
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methanediimine
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carbodiimide in the presence of an amine inhibits glycogen debranching enzyme, transferase activity is inhibited, amylo-1,6-glucosidase , hydrolysis of alpha-glucosyl fluoride, is unaffected by carbodiimide. Slow inactivation of glucosidase activity as measured by [14C]glucose incorporation into glycogen
mono-(2-ethylhexyl)phthalate
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inhibits the activity of oligo-1,4-1,4 glucanotransferase in bifunctional amylo-1,6-glucosidase oligo-1,4-1,4 glucanotransferase, but not that of amylo-1,6-glucosidase
N,N'-bis(tris[hydroxymethyl]methyl)-1,3-diaminopropane
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bis(tris)propane, noncompetitive
N-2-Hydroxyethylpiperazine-N'-2-ethanesulfonic acid
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slight inhibition
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid
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slight inhibition
1-deoxynojirimycin
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in primary rat hepatocytes, the inhibition of glycogen breakdown reaches plateau at 100 microM with 25% inhibition and then remains unchanged
1-S-dimethylarsino-1-thio-beta-D-glucanopyranoside
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DATG, active site-directed irreversible inhibitor, inhibition: mechanism. Inactivation occurs with significant conformational change
1-S-dimethylarsino-1-thio-beta-D-glucanopyranoside
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DATG, active site-directed irreversible inhibitor, inhibition: mechanism. Inactivation occurs with significant conformational change; glycogen phosphorylase limit dextrin and Bis-Tris protect from inactivation
2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
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Bis-Tris, reversible inhibitor
2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
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10 mM: 97% inhibition; Bis-Tris, reversible inhibitor
2,2-bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
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Bis-Tris, reversible inhibitor; noncompetitive with glycogen phosphorylase limit dextrin, competitive with glucose
Amine
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protonated, hydroxylalkyl-substituted, noncompetitive, mechanism of inhibition
Amine
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noncompetitive with glycogen phosphorylase limit dextrin, competitive with glucose; polyhydroxyamines, mechanism of inhibition; protonated, hydroxylalkyl-substituted, noncompetitive, mechanism of inhibition
guanidine
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muscle and liver enzyme: inhibition at very low concentrations
Urea
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muscle enzyme: reversible 95% inhibition by 2 M urea, with higher concentration, 3 M urea: time-dependent irreversible denaturation, liver enzyme: reversible 57% inhibition by 2 M urea
Urea
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muscle enzyme: reversible 95% inhibition by 2 M urea, with higher concentration, 3 M urea: time-dependent irreversible denaturation, liver enzyme: reversible 57% inhibition by 2 M urea; reversible inhibitor below 2 M, 90% inhibition by 2.6 M urea
Urea
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glucosidase-transferase: 31% inhibition at 0.21 M, 72% at 1.6 M, 98% at 3.2 M
additional information
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inhibition mechanism; no inhibition by dithioerythritol, dithiothreitol, cadaverine, spermidine, spermine, D,L-threitol, 1-thio-beta-D-glucose
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additional information
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no inhibition by usual sugar phosphates or nucleotide effectors of glycolysis such as AMP, ADP, ATP, uridine diphosphoglucose, glucose-1-phosphate, glucose-6-phosphate and phosphate
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