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3.2.1.33: amylo-alpha-1,6-glucosidase

This is an abbreviated version!
For detailed information about amylo-alpha-1,6-glucosidase, go to the full flat file.

Word Map on EC 3.2.1.33

Reaction

6-O-alpha-D-glucosyl cyclomaltoheptaose
+
H2O
=
D-glucose
 +
cyclomaltoheptaose

Synonyms

1,4-glucan-4-glucosyltransferase/amylo-1,6-glucosidase, 4-alpha-glucano-transferase amylo-1,6-glucosidase, alpha-(1,6)-glucosidase, alpha-1,6-glucosidase, amylo-1,6-glucosidase, amylo-1,6-glucosidase-oligo-1,4-1,4-transferase, amylo-1,6-glucosidase/1,4-alpha-glucan 4-alpha-glucan 4-alpha-glycosyltransferase, amylo-1,6-glucosidase/1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glycosyltransferase, amylo-1,6-glucosidase/4-alpha-glucanotransferase, amylo-1,6-glucosidase/oligo-1,4-1,4-glucantransferase, amylo-alpha-1,6-glucosidase, amylo-alpha-1,6-glucosidase activity, amyloglucosidase, amylopectin 1,6-glucosidase, debrancher enzyme, debrancher protein, dextrin 6-alpha-D-glucosidase, dextrin 6-alpha-glucosidase, dextrin 6-glucanohydrolase, dextrin 6-glucohydrolase, dextrin-1,6-glucosidase, dextrin:6-glucohydrolase, GDE, GDE amylo-alpha-1,6-glucosidase, glucosidase, amylo-1,6-, glucosidase/transferase, glycogen debranching enzyme, glycogen debranching system, glycogen phosphorylase dextrin 6-glucanohydrolase, glycogen phosphorylase limit dextrin alpha-1,6-glucohydrolase, glycogen phosphorylase limit dextrin debranching system, indirect debranching enzyme, NPDE, oligo-alpha-1,4-glucan:alpha-1,4-glucan-4-glycosyltransferase-amylo-1,6-glucosidase, SSO2094, transferase-glucosidase, TreX

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.33 amylo-alpha-1,6-glucosidase

Engineering

Engineering on EC 3.2.1.33 - amylo-alpha-1,6-glucosidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G1448R
mutation detected in patient with Glycogen Storage Disease Type III. Significant loss in both enzymatic activites and carbohydrate binding ability, as well as enhancing targeting for proteasomal degradation
L620P
mutation detected in patient with Glycogen Storage Disease Type III. Mutation abolishes transferase activity
R1147G
mutation detected in patient with Glycogen Storage Disease Type III. Mutation impairs glucosidase function
Y1445ins
mutation detected in patient with Glycogen Storage Disease Type III. Significant loss in both enzymatic activites and carbohydrate binding ability, as well as enhancing targeting for proteasomal degradation
D318A
sharp increasein alpha-1,4-transferase activity
E94A
minor change in the amylo-1,6-glucosidase activity
D1086N
-
loss of glucosidase activity
D1147N
-
loss of glucosidase activity
D535N
-
loss of transferase activity
D670N
-
loss of transferase activity
E564Q
-
loss of transferase activity