3.2.1.184: UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

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For detailed information about UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing), go to the full flat file.

Reaction

2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose

Synonyms

Cj1328, LeG, neuC, UDP-Bac2Ac4Ac 2-epimerase, UDP-N-acetylglucosamine 2-epimerase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.184 UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

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Results	in table
290	AA Sequence
2	Cloned(Commentary)
1	KM Value [mM]
2	Organism
3	Pathway
8	PDB ID
1	pH Optimum
2	Purification (Commentary)
3	Reaction
2	Reference
4	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.1.184 - UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

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UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising)

Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2].