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3.2.1.182: 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase

This is an abbreviated version!
For detailed information about 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, go to the full flat file.

Word Map on EC 3.2.1.182

Reaction

(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside
+
H2O
=
2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one
 +
D-glucose

Synonyms

benzoxazinone-glucoside beta-D-glucosidase, beta-glu, beta-glucosidase, Co-Glu, DIMBOA glucosidase, DIMBOAGlc hydrolase, GDIBOA-glucosidase, LgGLU1, LgGLU2, LgGLU3, LgGLU4, More, SbDhr1, ScGlu, TaGlu1, TaGlu1a, TaGlu1b, TaGlu1c, ZmGlu1

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.182 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase

Inhibitors

Inhibitors on EC 3.2.1.182 - 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(1-(4-(2-cyanophenyl)benzyl-1H-indol-3-yl),2,4-dihydro-1H-benzo(d)(1,3))oxazine
-
slight inhibition
2-(1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
2-(2-butyl-4-chloro-1H-imidazol-5-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
2-(2-methyl-1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
2-fluoro-2-deoxy-beta-D-glucose
3-(2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)-4H-chromen-4-one
-
slight inhibition
3-(6-chloro-2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)-4H-chromen-4-one
-
-
3-(6-methyl-2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)-4H-chromen-4-one
-
slight inhibition
4-(2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)phenol
-
-
4-(7-chloro-2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)phenol
-
anti-hyperglycemic effect via glucose uptake inhibition by the inhibitor in the starved rat model
4-Methylumbelliferone
-
-
4-nitrophenol
-
-
6-chloro-2-(2-phenyl-1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
6-methyl-2-(2-methyl-1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
6-methyl-2-(2-phenyl-1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
7-chloro-2-(1H-indol-3-yl)-2,4-dihydro-1H-benzo[d][1,3]oxazine
-
-
acarbose
-
-
castanospermine
-
-
D-gluconic acid lactone
-
-
Dhurrin
DIMBOA
-
-
additional information
-
synthesis of a library of 1,3-benzoxazine scaffold based aglycones by using 2-aminobenzyl alcohols and aldehydes from one-pot reaction in a chloroacetic acid catalytic system via aerobic oxidative synthesis, inhibitory potencies of the compounds, molecular docking studies, overview
-