3.2.1.180: unsaturated chondroitin disaccharide hydrolase
This is an abbreviated version!
For detailed information about unsaturated chondroitin disaccharide hydrolase, go to the full flat file.
Word Map on EC 3.2.1.180
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3.2.1.180
-
glucuronyl
-
disaccharides
-
lyases
-
streptococcal
-
glycosaminoglycans
-
polysaccharide
-
agalactiae
-
trimethylation
-
priming
-
histone
-
oncogenesis
-
trimethylase
- 3.2.1.180
-
glucuronyl
- disaccharides
-
lyases
- streptococcal
- glycosaminoglycans
- polysaccharide
- agalactiae
-
trimethylation
-
priming
- histone
-
oncogenesis
-
trimethylase
Reaction
Synonyms
Phep_2238, Phep_2649, Phep_2830, SagUGL, SpnUGL, SpyUGL, UGL, unsaturated glucuronyl hydrolase
ECTree
3.2.1.180 unsaturated chondroitin disaccharide hydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.2.1.180 - unsaturated chondroitin disaccharide hydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4,6-trichlorophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
2,4-dinitrophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
2,5-dinitrophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
2-(acetylamino)-2-deoxy-3-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-4-O-sulfo-D-galactopyranose + H2O
?
-
-
-
-
?
2-(acetylamino)-2-deoxy-3-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-6-O-sulfo-D-galactopyranose + H2O
?
-
-
-
-
?
2-(acetylamino)-2-deoxy-3-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-D-galactopyranose + H2O
?
-
-
-
-
?
2-acetamido-2-deoxy-3-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-6-O-sulfo-D-galactopyranose + H2O
2-acetamido-2-deoxy-6-O-sulfo-D-galactopyranose + 4-deoxy-alpha-L-threo-hex-4-enopyranose
-
high activity, a substrate with sulfation of the primary alcohol on carbon 6 of its N-acetylgalactosamine moiety
-
-
?
2-deoxy-4-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-2-(sulfoamino)-D-glucopyranose + H2O
?
-
-
-
-
?
3-nitrophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
4-chlorophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl fluoride + H2O
?
-
an unsaturated glucuronyl fluoride giving very low activity
-
-
?
4-deoxy-beta-L-threo-hex-4-enopyranuronosyl fluoride + H2O
?
-
an unsaturated glucuronyl fluoride giving very low activity
-
-
?
4-nitrophenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
4-tert-butylphenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
alpha-D-4-deoxy-DELTA4,5-IdoA-(1->4)-beta-D-GlcNAc + H2O
alpha-D-4-deoxy-DELTA4,5-IdoA + beta-D-N-acetylglucosamine
-
-
-
?
benzyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylglucosamine
beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate
-
-
-
-
?
phenyl 4-deoxy-alpha-L-threo-hex-4-enopyranosiduronic acid + H2O
?
-
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
3.4% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
kcat/Km is 2% of the kcat/Km-value for beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
3.4% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
16% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
10% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine
10% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylgalactosamine-6-O-sulfate
-
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylglucosamine
2% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylglucosamine
1.1% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GlcNAc + H2O
4-deoxy-L-threo-5-hexosulose-uronate + beta-D-N-acetylglucosamine
1.1% of the activity with beta-D-4-deoxy-DELTA4,5-GlcAp-(1->3)-beta-D-GalNAc6S
-
-
?
DELTAGlcUA-beta-(1->3)-GalNAc6S + H2O
?
best substrate
-
-
?
DELTAGlcUA-beta-(1->4)-GlcNAc + H2O
?
best substrate
-
-
?
additional information
?
-
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
-
almost all interactions between the substrate and enzyme are related to the D-glucuronic acid unit, whereas no recognition specificity is observed for the N-acetyl-D-galactosamine unit
-
-
?
additional information
?
-
-
unsaturated glucuronyl hydrolases acts on the unsaturated uronic-acid-containing oligosaccharides to remove the unusual non-reducing terminal monomer units
-
-
?
additional information
?
-
-
no or poor activity with 2-(acetylamino)-2-deoxy-4-O-(4-deoxy-alpha-L-threo-hex-4-enopyranuronosyl)-6-O-sulfo-D-glucopyranose and 2-(acetylamino)-2-deoxy-3-O-(4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronosyl)-D-galactopyranose
-
-
?
additional information
?
-
substrate specificity of type and mutant enzymes with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, substrate docking studies, overview
-
-
?
additional information
?
-
substrate specificity of type and mutant enzymes with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, substrate docking studies, overview
-
-
?
additional information
?
-
substrate specificity of type and mutant enzymes with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, substrate docking studies, overview
-
-
?
additional information
?
-
-
substrate specificity of type and mutant enzymes with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, substrate docking studies, overview
-
-
?
additional information
?
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
the streptococcal unsaturated glucuronyl hydrolases are capable of degrading unsaturated disaccharides derived from mammalian sulfated glycosaminoglycans. This substrate specificity probably enables Streptococci to readily invade mammalian cells through the degradation of extracellular sulfated glycosaminoglycans
-
-
?
additional information
?
-
shows almost no activity with the unsaturated gellan tetrasaccharide (beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp). Streptococcal enzymes prefer sulfated substrates
-
-
?
additional information
?
-
the enzyme acts on unsaturated alpha-iduronic acid as well as unsaturated beta-glucuronic acis residues in substrates, and cleaves both glycoside bonds (1->3) and (1->4)
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant enzymes with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
the streptococcal unsaturated glucuronyl hydrolases are capable of degrading unsaturated disaccharides derived from mammalian sulfated glycosaminoglycans. This substrate specificity probably enables Streptococci to readily invade mammalian cells through the degradation of extracellular sulfated glycosaminoglycans
-
-
?
additional information
?
-
shows almost no activity with the unsaturated gellan tetrasaccharide (beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp). Streptococcal enzymes prefer sulfated substrates
-
-
?
additional information
?
-
the streptococcal unsaturated glucuronyl hydrolases are capable of degrading unsaturated disaccharides derived from mammalian sulfated glycosaminoglycans. This substrate specificity probably enables Streptococci to readily invade mammalian cells through the degradation of extracellular sulfated glycosaminoglycans
-
-
?
additional information
?
-
shows almost no activity with the unsaturated gellan tetrasaccharide (beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp). Streptococcal enzymes prefer sulfated substrates
-
-
?
additional information
?
-
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
the streptococcal unsaturated glucuronyl hydrolases are capable of degrading unsaturated disaccharides derived from mammalian sulfated glycosaminoglycans. This substrate specificity probably enables Streptococci to readily invade mammalian cells through the degradation of extracellular sulfated glycosaminoglycans
-
-
?
additional information
?
-
shows almost no activity with the unsaturated gellan tetrasaccharide (beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp). Streptococcal enzymes prefer sulfated substrates
-
-
?
additional information
?
-
-
substrate specificity with unsaturated chondroitin disaccharides and unsaturated heparin disaccharides, overview
-
-
?
additional information
?
-
the streptococcal unsaturated glucuronyl hydrolases are capable of degrading unsaturated disaccharides derived from mammalian sulfated glycosaminoglycans. This substrate specificity probably enables Streptococci to readily invade mammalian cells through the degradation of extracellular sulfated glycosaminoglycans
-
-
?
additional information
?
-
shows almost no activity with the unsaturated gellan tetrasaccharide (beta-D-4-deoxy-DELTA4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp). Streptococcal enzymes prefer sulfated substrates
-
-
?
