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3.2.1.180: unsaturated chondroitin disaccharide hydrolase

This is an abbreviated version!
For detailed information about unsaturated chondroitin disaccharide hydrolase, go to the full flat file.

Word Map on EC 3.2.1.180

Reaction

beta-D-4-deoxy-DELTA4-GlcAp-(1->3)-beta-D-GalNAc6S
+
H2O
=
5-dehydro-4-deoxy-D-glucuronate
 +
N-acetyl-beta-D-galactosamine-6-O-sulfate

Synonyms

Phep_2238, Phep_2649, Phep_2830, SagUGL, SpnUGL, SpyUGL, UGL, unsaturated glucuronyl hydrolase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.180 unsaturated chondroitin disaccharide hydrolase

Inhibitors

Inhibitors on EC 3.2.1.180 - unsaturated chondroitin disaccharide hydrolase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R)-pyrrolidinium-2-carboxylate
-
-
(2R,3R,4S,5S,6R)-3,4,5,6-tetrahydroxypiperidine-2-carboxylic acid
-
competitive
(2S)-pyrrolidinium-2-carboxylate
-
-
(3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid
-
competitive
2-mercaptoethanol
1 mM, 20% inhibition
AlCl3
1 mM, 65% inhibition
CoCl2
1 mM, 55% inhibition
D-galactose
5 mM, 21% inhibition
D-galacturonic acid
D-GlcA
5 mM, 97% inhibition
D-glucose
5 mM, 40% inhibition
D-glucuronic acid
D-mannose
5 mM, 22% inhibition
D-xylose
5 mM, 33% inhibition
KCl
1 mM, 22% inhibition
L-fucose
5 mM, 50% inhibition
L-rhamnose
5 mM, 35% inhibition
LiCl
1 mM, 24% inhibition
MnCl2
1 mM, 27% inhibition
N-acetylglucosamine
5 mM, 17% inhibition
NaCl
1 mM, 22% inhibition
additional information
-
several analogues designed to take advantage ofstrong enzyme binding to the reaction's transition state show little to no inhibition. No inhibition by 17a and 17b
-