3.2.1.180: unsaturated chondroitin disaccharide hydrolase
This is an abbreviated version!
For detailed information about unsaturated chondroitin disaccharide hydrolase, go to the full flat file.
Word Map on EC 3.2.1.180
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3.2.1.180
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glucuronyl
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disaccharides
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lyases
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streptococcal
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glycosaminoglycans
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polysaccharide
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agalactiae
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trimethylation
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priming
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histone
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oncogenesis
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trimethylase
- 3.2.1.180
-
glucuronyl
- disaccharides
-
lyases
- streptococcal
- glycosaminoglycans
- polysaccharide
- agalactiae
-
trimethylation
-
priming
- histone
-
oncogenesis
-
trimethylase
Reaction
Synonyms
Phep_2238, Phep_2649, Phep_2830, SagUGL, SpnUGL, SpyUGL, UGL, unsaturated glucuronyl hydrolase
ECTree
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General Information
General Information on EC 3.2.1.180 - unsaturated chondroitin disaccharide hydrolase
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evolution
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the enzyme is a member of the glycoside hydrolase family 88, GH88
metabolism
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the enzyme is involved in the metabolic pathway for degradation of glycosaminoglycans
physiological function
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unsaturated glucuronyl hydrolases acts on the unsaturated uronic-acid-containing oligosaccharides to remove the unusual non-reducing terminal monomer units
additional information
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a hydration-initiated mechanism with a transition state with positive charge at carbon 5 and the endocyclic oxygen is proposed, transition-state structure for the first irreversible step of this mechanism, overview
additional information
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glycosaminoglycan degradation mechanism, combined quantum mechanical and molecular mechanical method and simulation, modelling, two pathways, detailed overview. Almost all interactions between the substrate and enzyme are related to the D-glucuronic acid unit, whereas no recognition specificity is observed for the N-acetyl-D-galactosamine unit