3.2.1.176: cellulose 1,4-beta-cellobiosidase (reducing end)

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For detailed information about cellulose 1,4-beta-cellobiosidase (reducing end), go to the full flat file.

Reaction

2 cellohexaose + 2 H2O = 2 cellotriose +

Synonyms

1,4-beta-D-glucan cellobiohydrolase I, 1,4-beta-D-glucan-cellobiohydrolase I, CBH, CBH I, CBH Ib, CBH-1, CBH1, CBH2, Cbh3, Cbh7B, CbhA, CBHI, CbhI.1, Cel48A, Cel48C, Cel48S, Cel48S cellulase, Cel48Y cellulase, Cel6A, Cel7A, Cel7B, Cel7D, Cel9B, cellobiohydrolase, cellobiohydrolase 1, cellobiohydrolase A, cellobiohydrolase CelS, cellobiohydrolase class I, cellobiohydrolase I, cellobiohydrolase I-I, cellobiohydrolase I-II, cellobiohydrolase II, cellobiohydrolase II-I, Celluclast, Cellulase SS, CelO, celS, CelSS, CelY, Ct-Cel5F, DDB0202233, DICPUDRAFT_151874, EG I, EgxS, endoglucanase, endoglucanase SS, exo-1,4-beta-glucanase, exo-acting cellulase, exo-beta-1,4-glucanase, exocellulase, exocellulase E4, exocellulase E6, exoglucanase, exoglucanase S, exoglucanase-1, GH7 CBH, More, reducing end acting processive exocellulase, reducing end-acting CBH, Tfu_1959, ThCel7A, THITE_62596, Tr-Cel7A

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.176 cellulose 1,4-beta-cellobiosidase (reducing end)

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Results	in table
8	Activating Compound
155	AA Sequence
25	Application
59	Cloned(Commentary)
32	Crystallization (Commentary)
2	Expression
25	General Information
2	General Stability
1	IC50 Value
79	Inhibitors
23	kcat/KM [mM/s]
45	Ki Value [mM]
111	KM Value [mM]
11	Localization
10	Metals/Ions
36	Molecular Weight [Da]
56	Natural Substrates/ Products (Substrates)
248	Organism
2	Pathway
21	PDB ID
46	pH Optimum
6	pH Range
6	pH Stability
12	pI Value
29	Posttranslational Modification
131	Protein Variants
57	Purification (Commentary)
5	Reaction
1	Reaction Type
183	Reference
1	Renatured (Commentary)
5	Source Tissue
46	Specific Activity [micromol/min/mg]
447	Substrates and Products (Substrate)
49	Subunits
328	Synonyms
1	Systematic Name
40	Temperature Optimum [°C]
7	Temperature Range [°C]
48	Temperature Stability [°C]
78	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.1.176 - cellulose 1,4-beta-cellobiosidase (reducing end)

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SYSTEMATIC NAME

IUBMB Comments

4-beta-D-glucan cellobiohydrolase (reducing end)

Some exocellulases, most of which belong to the glycoside hydrolase family 48 (GH48, formerly known as cellulase family L), act at the reducing ends of cellulose and similar substrates. The CelS enzyme from Clostridium thermocellum is the most abundant subunit of the cellulosome formed by the organism. It liberates cellobiose units from the reducing end by hydrolysis of the glycosidic bond, employing an inverting reaction mechanism [2]. Different from EC 3.2.1.91, which attacks cellulose from the non-reducing end.