3.2.1.169: protein O-GlcNAcase

This is an abbreviated version!
For detailed information about protein O-GlcNAcase, go to the full flat file.

Word Map on EC 3.2.1.169

3.2.1.169

o-glcnacylation

streptozotocin

o-glycosylation

nucleocytoplasmic

beta-cell

diabetogenic

perfringens

thiamet

pugnacity

tetratricopeptide

thetaiotaomicron

substrate-assisted

hexosaminidases

medicine

Reaction

[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine

Synonyms

beta-N-acetylglucosaminidase, BtGH84, CP40, CpNagJ, CpOGA, cytoplasmic O-GlcNAcase, endo-beta-N-acetylglucosaminidase, EndoS-like endoglycosidase, glycoside hydrolase O-GlcNAcase, hexosaminidase, hOGA, mNCOAT, NagJ, NCOAT, neutral hexosaminidase C, neutral O-GlcNAcase, O-GlcNAc hydrolase, O-GlcNAc selective N-acetyl-beta-D-glucosaminidase, O-GlcNAc specific beta-N-acetylglucosaminidase, O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase, O-GlcNAc-selective-N-acetyl-beta-D-glucosaminidase, O-GlcNAcase, O-linked beta-N-acetyl glucosaminase, O-linked N-acetylglucosaminase, OGA, OGA-FL, OGA-NV

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.169 protein O-GlcNAcase

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Results	in table
2	Activating Compound
299	AA Sequence
2	Application
17	Cloned(Commentary)
7	Crystallization (Commentary)
11	Disease/ Diagnostics
1	Expression
3	General Information
18	IC50 Value
115	Inhibitors
74	kcat/KM [mM/s]
66	Ki Value [mM]
77	KM Value [mM]
6	Localization
5	Metals/Ions
7	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
36	Organism
1	Pathway
102	PDB ID
11	pH Optimum
1	pH Stability
1	pI Value
41	Protein Variants
16	Purification (Commentary)
2	Reaction
36	Reference
27	Source Tissue
5	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
4	Subunits
84	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
27	Turnover Number [1/s]

KM Value

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KM Value on EC 3.2.1.169 - protein O-GlcNAcase

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0.21 - 0.56

3,4-dinitrophenyl N-acetyl-beta-D-glucosaminide

4 entries

0.3 - 0.73

3-fluoro-4-nitrophenyl N-acetyl-beta-D-glucosaminide

4 entries

0.47 - 0.95

3-nitrophenyl N-acetyl-beta-D-glucosaminide

2 entries

0.56

4-chlorophenyl N-acetyl-beta-D-glucosaminide

Homo sapiens

wild-type

702209

0.08 - 1

4-methylumbelliferyl 2-acetamido-2-deoxy-beta-D-glucopyranoside

2 entries

0.0029 - 1.4

4-methylumbelliferyl N-acetyl-beta-D-glucosaminide

12 entries

0.45

4-methylumbelliferyl N-difluoroacetyl-beta-D-glucosaminide

Homo sapiens

704414

0.49

4-methylumbelliferyl N-fluoroacetyl-beta-D-glucosaminide

Homo sapiens

704414

0.38

4-methylumbelliferyl N-trifluoroacetyl-beta-D-glucosaminide

Homo sapiens

704414

0.0029 - 0.1

4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide

3 entries

0.016 - 36

4-nitrophenyl N-acetyl-beta-D-glucosaminide

36 entries

1.4

4-nitrophenyl N-acetyl-beta-D-thioglucosaminide

Bacteroides thetaiotaomicron

Q89ZI2

705869

2.5 - 5

4-nitrophenyl-beta-D-GlcNAc

Rattus norvegicus

708967

0.0849 - 2.1

fluorescein di(N-acetyl-beta-D-glucosaminide)

2 entries

0.84

N-acetyl-4-aminophenyl N-acetyl-beta-D-glucosaminide

Homo sapiens

wild-type

702209

1.5 - 3.6

N-acetyl-beta-D-glucosamine

2 entries

0.62 - 0.95

phenyl N-acetyl-beta-D-glucosaminide

2 entries