3.2.1.169: protein O-GlcNAcase

This is an abbreviated version!
For detailed information about protein O-GlcNAcase, go to the full flat file.

Reaction

Synonyms

beta-N-acetylglucosaminidase, BtGH84, CP40, CpNagJ, CpOGA, cytoplasmic O-GlcNAcase, endo-beta-N-acetylglucosaminidase, EndoS-like endoglycosidase, glycoside hydrolase O-GlcNAcase, hexosaminidase, hOGA, mNCOAT, NagJ, NCOAT, neutral hexosaminidase C, neutral O-GlcNAcase, O-GlcNAc hydrolase, O-GlcNAc selective N-acetyl-beta-D-glucosaminidase, O-GlcNAc specific beta-N-acetylglucosaminidase, O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase, O-GlcNAc-selective-N-acetyl-beta-D-glucosaminidase, O-GlcNAcase, O-linked beta-N-acetyl glucosaminase, O-linked N-acetylglucosaminase, OGA, OGA-FL, OGA-NV

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.169 protein O-GlcNAcase

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Results	in table
2	Activating Compound
299	AA Sequence
2	Application
17	Cloned(Commentary)
7	Crystallization (Commentary)
11	Disease/ Diagnostics
1	Expression
3	General Information
18	IC50 Value
115	Inhibitors
74	kcat/KM [mM/s]
66	Ki Value [mM]
77	KM Value [mM]
6	Localization
5	Metals/Ions
7	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
36	Organism
1	Pathway
102	PDB ID
11	pH Optimum
1	pH Stability
1	pI Value
41	Protein Variants
16	Purification (Commentary)
2	Reaction
36	Reference
27	Source Tissue
5	Specific Activity [micromol/min/mg]
162	Substrates and Products (Substrate)
4	Subunits
84	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
27	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.2.1.169 - protein O-GlcNAcase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

visualization of the reaction coordinate of O-GlcNAc hydrolases

Bacteroides thetaiotaomicron

Q89ZI2

704200

X-ray crystal structure of BtGH84 in complex with the inhibitor NAG-thiazoline. Hanging drop vapor diffusion method

Bacteroides thetaiotaomicron

Q89ZI2

705869

X-ray crystallography

Bacteroides thetaiotaomicron

Q89ZI2

703067

significant sequence homology to the human O-GlcNAcase N-terminus

Clostridium perfringens

Q0TR53

703438

sitting drop vapor diffusion method, using 0.175 M CdSO4 and 0.1 M sodium acetate at pH 7.5

Clostridium perfringens

Q0TR53

749464

enzyme in apo and inhibited states, hanging drop vapor diffusion method

Homo sapiens

O60502

751642

mutant enzyme D175N in complex with alpha-crystallin B, TAB1 protein, ELK1 protein or lamin B1, hanging drop vapor diffusion method, using 0.032 M ammonium citrate tribasic (pH 7.0), 0.02M MES monohydrate, 0.128 M potassium thiocyanate, 0.016M imidazole, 0.002 M zinc sulfate heptahydrate, 12.8% (w/v) polyethylene glycol 3350, 3.2% (w/v) polyethylene glycol monomethyl ether 2000, and 5% (w/v) polyethylene glycol monomethyl ether 550

Homo sapiens

O60502

751664