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3.2.1.144: 3-deoxyoctulosonase

This is an abbreviated version!
For detailed information about 3-deoxyoctulosonase, go to the full flat file.

Reaction

3-deoxyoctulosonyl-lipopolysaccharide
+
H2O
=
3-deoxyoctulosonic acid
+
lipopolysaccharide

Synonyms

3-deoxy-D-manno-oct-2-ulosonic acid alpha-ketoside hydrolase, 3-deoxy-octulo-sonase, alpha-Kdo-ase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.144 3-deoxyoctulosonase

Natural Substrates Products

Natural Substrates Products on EC 3.2.1.144 - 3-deoxyoctulosonase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
re-lipopolysaccharide + H2O
3-deoxy-D-manno-octulosonic acid + lipopolysaccharide
show the reaction diagram
-
-
-
?
additional information
?
-
the recombinant alpha-Kdo-ase effectively hydrolyzes the alpha-ketoside in the core-oligosaccharide of the structurally defined lipopolysaccharide (LPS), Re-LPS (Kdo2-lipid A) from Salmonella minnesota strain R595 and Escherichia coli strain D31m4, while Rd-LPS from Salmonella minnesota strain R7, that contains an extra outer core phosphorylated heptose, is only slowly hydrolyzed. The complex type LPS from Neisseria meningitides strains A1 and M992 that contain extra 5-6 sugar units at the outer core are refractory to recombinnat alpha-Kdo-ase
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?