3.2.1.14: chitinase

This is an abbreviated version!
For detailed information about chitinase, go to the full flat file.

Reaction

Synonyms

1,4-beta-poly-N-acetylglucosaminidase, AcD1ChiA, acid mammalian chitinase, acidic chitinase, acidic mammalian chitinase, active phase-associated protein I, active phase-associated protein II, AD2PF-ChiA, AgChi, alpha-chitinase, AMCase, antifreeze protein, APAP1, APAP2, APAPI, APAPII, AtChiC, B220, bacterial-type chitinase, Bbchit1, BChi14, beta-1,4-poly-N-acetyl glucosamidinase, BjCHI1, BJL200-ChiC1, CF-AG, CF-antigen, CGCHI3, CH5B, ChBDChiC, CHI, Chi-1, CHI-26, Chi-A, Chi-h, Chi1, Chi18A, Chi18B, Chi18C, Chi19, CHI2, Chi2 enzyme, Chi21, Chi22, Chi3, Chi31, Chi35, Chi40, Chi44, Chi46, Chi54, CHI60, Chi67, Chi70, Chi72, Chi78, ChiA, ChiA Nima, ChiA protein, ChiA-HD73, ChiA-Hh59, ChiA-Mt45, ChiA1, ChiA74, ChiB, ChiC, ChiCW, ChiD, ChiE, ChiEN1, ChiF, ChiF1, ChiG, ChiNCTU2, Chit, CHIT 1A, CHIT 1B, CHIT1, Chit1b, Chit33, CHIT42, Chit62, ChitA, ChitIII-1, ChitIII-2, chitinase, chitinase 1, chitinase 18C, chitinase 2, chitinase 60, chitinase 92, chitinase A, chitinase A1, chitinase B, chitinase C, chitinase C1, chitinase Chi255, chitinase F1, chitinase G, chitinase I, chitinase II, chitinase III, chitinase-A, chitinases A, chitinolytic enzyme, chitodextrinase-N-, chitotriosidase, ChiW, CHT1, Cht4, CHT7, ChtII, ChtIII, CiX1, class I chitinase, class II chitinase, class III chitinase, class IV chitinase, class V chitinase, Complement-fixation antigen, CpCHI, CrChi1, CTS1, ECH, ECH1, Ech42, ech46, ELC, endo-chitinase, endochitinase, endochitinase 1, endochitinase-1, endochitinase-2, exochitinase, GAC1, GAC2, GH18 chitinase, group I chitinase, group II chitinase, group III chitinase, hevamine, HoChiA, HoChiB, HoChiC, HschiA1, Is-chiB, LlChi18A, LpChiA, MACase, MF1 antigen, MmChi60, More, MsChi386, MsChi535, NaCHIT1, NaCHIT3, NtChitIV, NtChiV, OfChtI, OsChia1b, OsChia1c, OsChia1cDELTAChBD, OsChia1d, OsChia2a, OsChia2b, OsChia4a, OsChib1a, PF1233, PjChi-1, plant class III chitinase, PLC-A, PLC-B, PLChiA, poly-beta-1, 4-[2-acetamido-2-deoxy]-delta-glucoside glycanohydrolase, poly-beta-glucosaminidase, PrChi-A, Ptchi19p, Ra-ChiC, RCB4, RHBC, sAMC, SCChi-1, SI-CLP, SjChi, SsChi50, stabilin-1 interacting chitinase-like protein, STK_09390, TBC-1, Tfu_0580, Tk-ChiA, TKU028 chitinase, TmChi, TSA1902, UDA, V-CHIA, VpChiA, WIN6, YlCts1p, Ym1

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.14 chitinase

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Results	in table
54	Activating Compound
21531	AA Sequence
47	Application
1	CAS Registry Number
185	Cloned(Commentary)
39	Crystallization (Commentary)
3723	Disease/ Diagnostics
17	Expression
94	General Information
12	General Stability
8	IC50 Value
448	Inhibitors
35	kcat/KM [mM/s]
18	Ki Value [mM]
186	KM Value [mM]
131	Localization
115	Metals/Ions
296	Molecular Weight [Da]
155	Natural Substrates/ Products (Substrates)
12	Organic Solvent Stability
817	Organism
5	Pathway
372	PDB ID
274	pH Optimum
106	pH Range
91	pH Stability
53	pI Value
26	Posttranslational Modification
262	Protein Variants
216	Purification (Commentary)
15	Reaction
1	Reaction Type
554	Reference
2	Renatured (Commentary)
249	Source Tissue
243	Specific Activity [micromol/min/mg]
28	Storage Stability
1350	Substrates and Products (Substrate)
337	Subunits
449	Synonyms
1	Systematic Name
221	Temperature Optimum [°C]
65	Temperature Range [°C]
193	Temperature Stability [°C]
165	Turnover Number [1/s]

Reaction

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Reaction on EC 3.2.1.14 - chitinase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

chitopentaose + H2O = chitobiose + chitotriose

15 entries

chitopentaose + H2O = chitobiose + chitotriose

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-

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-

chitopentaose + H2O = chitobiose + chitotriose

catalytic reaction mechanism involving Glu119, overview

Homo sapiens

Q9BZP6

664134

chitopentaose + H2O = chitobiose + chitotriose

exo-type substrate cleavage mechanism

Trichoderma reesei

-

663742

chitopentaose + H2O = chitobiose + chitotriose

reaction mechanism, Glu315 is the acid/base during hydrolysis, the side-chain of the preceding Asp313 helps to position the N-acetyl moiety of the glycosyl sugar undergoing hydrolysis correctly, mutation of the conserved Tryp167 in the chitin-binding cleft of chitinase A enhances transglycosylation, transglycosylation reaction scheme, overview

Serratia marcescens

P07254

664383

chitopentaose + H2O = chitobiose + chitotriose

the enzyme shows endo- and exo-hydrolytic activity, as well as transglycosylation activity

Aspergillus fumigatus

-

663496

chitopentaose + H2O = chitobiose + chitotriose

catalytic mechanism, overview

Carica papaya

P85084

690990

chitopentaose + H2O = chitobiose + chitotriose

catalytic mechanism with an important role of Trp-33 on enzyme processivity, CHI60 preferentially uses the endo-type mode on soluble and amorphous substrates and the exo-type mode on crystalline substrate, the enzyme hydrolyzes crystalline substrates with an exo-type mode processively while remaining tightly bound to the substrate. The prevalent mode of hydrolysis mediated by CHI60 is regulated by ionic strength

Serratia sp.

Q93LF1

691649

chitopentaose + H2O = chitobiose + chitotriose

chitooligosaccharide-binding modes and catalytic mechanism, overview

Vibrio harveyi

-

693891

chitopentaose + H2O = chitobiose + chitotriose

mode of action of ChiG, family 19 chitinases use a single-displacement reaction with inversion of the configuration of the anomeric carbon, overview

Streptomyces coelicolor

-

691185

chitopentaose + H2O = chitobiose + chitotriose

double displacement reaction mechanism, overview

Serratia marcescens

E5FGC5

729155

chitopentaose + H2O = chitobiose + chitotriose

mode of action of ChiG, family 19 chitinases use a single-displacement reaction with inversion of the configuration of the anomeric carbon, overview

Streptomyces coelicolor A3(2)

-

-

chitopentaose + H2O = chitobiose + chitotriose

double displacement reaction mechanism, overview

Serratia marcescens B4A

-

-

chitopentaose + H2O = chitobiose + chitotriose

exo-type substrate cleavage mechanism

Trichoderma reesei PC-3-7

-

-

chitopentaose + H2O = chitobiose + chitotriose

the enzyme shows endo- and exo-hydrolytic activity, as well as transglycosylation activity

Aspergillus fumigatus YJ-407

-

-

chitopentaose + H2O = chitobiose + chitotriose

catalytic mechanism with an important role of Trp-33 on enzyme processivity, CHI60 preferentially uses the endo-type mode on soluble and amorphous substrates and the exo-type mode on crystalline substrate, the enzyme hydrolyzes crystalline substrates with an exo-type mode processively while remaining tightly bound to the substrate. The prevalent mode of hydrolysis mediated by CHI60 is regulated by ionic strength

Serratia sp. TU09

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