3.2.1.123: endoglycosylceramidase

This is an abbreviated version!
For detailed information about endoglycosylceramidase, go to the full flat file.

Word Map on EC 3.2.1.123

3.2.1.123

glycosphingolipids

gangliosides

cgases

n-deacylase

yamagata

ganglio

macrobdella

decora

gm1a

diagnostics

analysis

drug development

medicine

Reaction

Synonyms

ceramidase, endoglycosyl-, ceramide glycanase, EGALC, EGC, EGCase, EGCase I, EGCase II, EGCase III, EGCII, EGCrP1, EGCrP2, endo-glycoceramidase II, endogalactosylceramidase, endoglycoceramidase, endoglycoceramidase I, endoglycoceramidase II, endoglycoceramidase-related protein, glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase, oligogalactosyl-N-acylsphingosine 1,1'-beta-galactohydrolase

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

3.2.1.123 endoglycosylceramidase

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Results	in table
28	Activating Compound
62	AA Sequence
6	Application
1	CAS Registry Number
14	Cloned(Commentary)
3	Crystallization (Commentary)
5	General Stability
32	Inhibitors
11	kcat/KM [mM/s]
3	Ki Value [mM]
27	KM Value [mM]
6	Localization
5	Metals/Ions
16	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
66	Organism
1	Oxidation Stability
11	PDB ID
25	pH Optimum
3	pH Range
4	pH Stability
6	pI Value
1	Posttranslational Modification
39	Protein Variants
16	Purification (Commentary)
1	Reaction
3	Reaction Type
56	Reference
13	Source Tissue
24	Specific Activity [micromol/min/mg]
3	Storage Stability
239	Substrates and Products (Substrate)
12	Subunits
75	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
14	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.2.1.123 - endoglycosylceramidase

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(3R,4R,5R)-4-(beta-D-glucopyranosyl)oxy-3-hydroxy-5-(hydroxymethyl)piperidine

Rhodococcus sp.

677557

(5R,6R,7S,8S)-6-(beta-D-glucopyranosyloxy)-5,6,7,8-tetrahydro-5-(hydroxymethyl)imidazo-[1,2-a]pyridine-7,8-diol

Rhodococcus sp.

677557

1-(4-dimethylamino)benzoylamino-1,2,5-trideoxy-2,5-imino-d-mannitol

Rhodococcus sp.

677557

Ag+

Rhodococcus sp.

1 mM, 63% inhibition of endoglycoceramidase I, 94% inhibition of endoglycoceramidase II

Brij 58

Ca2+

87% inhibition at 5 mM

646702

Cu2+

3 entries

DMSO

Cryptococcus neoformans

inhibits enzyme activity at concentrations higher than 30% (v/v)

732178

ethanol

Cyanea nozakii

excess amounts inhibit

Fe3+

Hg2+

methanol

excess amounts inhibit

646694

SDS

Cyanea nozakii

Q9GV16

complete inhibition at 0.1%

taurodeoxycholate

Tween 20

Zn2+

additional information

2 entries