3.2.1.113: mannosyl-oligosaccharide 1,2-alpha-mannosidase

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For detailed information about mannosyl-oligosaccharide 1,2-alpha-mannosidase, go to the full flat file.

Reaction

Synonyms

(alpha1,2)-mannosidase-I, 1,2-alpha-mannosidase, alpha-(1->2)-mannosidase I, alpha-1,2 mannosidase I, alpha-1,2-mannosidase, alpha-1,2-mannosidase IC, alpha-1,2-mannosidaseI, alpha-1-2-mannosidase, alpha-mannosidase, alpha1,2-mannosidase, alpha1,2-mannosidase I, alpha1-2-mannosidase I, At1g51590, At3g21160, class I endoplasmic reticulum 1,2-alpha-mannosidase, D2030.1, endoplasmic reticulum mannosidase I, ER alpha-1,2-mannosidase, ER-Man, exo-alpha-1,2-mannanase, FmanIBp, fungal alpha-1,2-mannosidase, glycoprotein processing mannosidase I, Golgi alpha-mannosidase I, Golgi alpha1,2-mannosidase I, Golgi alpha1,2-mannosidase IA, Golgi alpha1,2-mannosidase IB, Golgi alpha1,2-mannosidase IC, Golgi alpha1,2-mannosidase II, GolgiManI, HMIC, Man(9)-alpha-mannosidase, MAN1A1, MAN1A2, MAN1B1, MAN1C1, Man9 processing alpha-mannosidase, Man9-alpha-mannosidase, Man9-mannosidase, Man9GlcNAc2-specific processing alpha-mannosidase, manE, ManI, MANIa, ManIA2, MANIb, ManIC, mannose-9 processing alpha-mannosidase, mannosidase 1A, mannosidase 1B, mannosidase I, mannosidase, exo-1,2-alpha-, Mas1, MIa, MIa,b,c, MIb, MIc, MII, MIIx, MNS1, Mns1p, MNS2, msdC, N-glycan processing class I alpha-1,2-mannosidase, processing alpha-1,2-mannosidase IC

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase

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Results	in table
11	Activating Compound
209	AA Sequence
4	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Crystallization (Commentary)
34653	Disease/ Diagnostics
3	Expression
20	General Information
4	General Stability
11	IC50 Value
124	Inhibitors
4	Ki Value [mM]
13	KM Value [mM]
72	Localization
43	Metals/Ions
18	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
425	Organism
4	Pathway
30	PDB ID
23	pH Optimum
11	pH Range
4	pH Stability
3	pI Value
6	Posttranslational Modification
28	Protein Variants
27	Purification (Commentary)
10	Reaction
2	Reaction Type
76	Reference
65	Source Tissue
12	Specific Activity [micromol/min/mg]
9	Storage Stability
146	Substrates and Products (Substrate)
22	Subunits
111	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.2.1.113 - mannosyl-oligosaccharide 1,2-alpha-mannosidase

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SYSTEMATIC NAME

IUBMB Comments

Man9GlcNAc2-[protein] alpha-2-mannohydrolase (configuration-inverting)

This family of mammalian enzymes, located in the Golgi system, participates in the maturation process of N-glycans that leads to formation of hybrid and complex structures. The enzymes catalyse the hydrolysis of the four (1->2)-linked alpha-D-mannose residues from the Man9GlcNAc2 oligosaccharide attached to target proteins as described in reaction (1). Alternatively, the enzymes act on the Man8GlcNAc2 isomer formed by EC 3.2.1.209, endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase, as described in reaction (2). The enzymes are type II membrane proteins, require Ca2+, and use an inverting mechanism. While all three human enzymes can catalyse the reactions listed here, some of the enzymes can additionally catalyse hydrolysis in an alternative order, generating additional isomeric intermediates, although the final product is the same. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7].