3.2.1.113: mannosyl-oligosaccharide 1,2-alpha-mannosidase

This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide 1,2-alpha-mannosidase, go to the full flat file.

Reaction

Synonyms

(alpha1,2)-mannosidase-I, 1,2-alpha-mannosidase, alpha-(1->2)-mannosidase I, alpha-1,2 mannosidase I, alpha-1,2-mannosidase, alpha-1,2-mannosidase IC, alpha-1,2-mannosidaseI, alpha-1-2-mannosidase, alpha-mannosidase, alpha1,2-mannosidase, alpha1,2-mannosidase I, alpha1-2-mannosidase I, At1g51590, At3g21160, class I endoplasmic reticulum 1,2-alpha-mannosidase, D2030.1, endoplasmic reticulum mannosidase I, ER alpha-1,2-mannosidase, ER-Man, exo-alpha-1,2-mannanase, FmanIBp, fungal alpha-1,2-mannosidase, glycoprotein processing mannosidase I, Golgi alpha-mannosidase I, Golgi alpha1,2-mannosidase I, Golgi alpha1,2-mannosidase IA, Golgi alpha1,2-mannosidase IB, Golgi alpha1,2-mannosidase IC, Golgi alpha1,2-mannosidase II, GolgiManI, HMIC, Man(9)-alpha-mannosidase, MAN1A1, MAN1A2, MAN1B1, MAN1C1, Man9 processing alpha-mannosidase, Man9-alpha-mannosidase, Man9-mannosidase, Man9GlcNAc2-specific processing alpha-mannosidase, manE, ManI, MANIa, ManIA2, MANIb, ManIC, mannose-9 processing alpha-mannosidase, mannosidase 1A, mannosidase 1B, mannosidase I, mannosidase, exo-1,2-alpha-, Mas1, MIa, MIa,b,c, MIb, MIc, MII, MIIx, MNS1, Mns1p, MNS2, msdC, N-glycan processing class I alpha-1,2-mannosidase, processing alpha-1,2-mannosidase IC

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.113 mannosyl-oligosaccharide 1,2-alpha-mannosidase

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Results	in table
11	Activating Compound
209	AA Sequence
4	Application
1	CAS Registry Number
18	Cloned(Commentary)
7	Crystallization (Commentary)
34653	Disease/ Diagnostics
3	Expression
20	General Information
4	General Stability
11	IC50 Value
124	Inhibitors
4	Ki Value [mM]
13	KM Value [mM]
72	Localization
43	Metals/Ions
18	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
425	Organism
4	Pathway
30	PDB ID
23	pH Optimum
11	pH Range
4	pH Stability
3	pI Value
6	Posttranslational Modification
28	Protein Variants
27	Purification (Commentary)
10	Reaction
2	Reaction Type
76	Reference
65	Source Tissue
12	Specific Activity [micromol/min/mg]
9	Storage Stability
146	Substrates and Products (Substrate)
22	Subunits
111	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
4	Turnover Number [1/s]

General Information

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General Information on EC 3.2.1.113 - mannosyl-oligosaccharide 1,2-alpha-mannosidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

5 entries

metabolism

5 entries

physiological function

10 entries

malfunction

Mus musculus

-

blocking alpha-1,2-mannosidase in regulatory T cells results in the migration of significantly lower numbers to the peripheral lymph nodes in skin grafted mice following adoptive transfer

706455

malfunction

Homo sapiens

P33908, Q9NR34

aberrant regulation of alpha-1,2 mannosidases can result in cancer. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis

750718

malfunction

Homo sapiens

P33908, Q9NR34

aberrant regulation of alpha-1,2 mannosidases can result in cancer. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis

750718

malfunction

Arabidopsis thaliana

Q8H116, Q9C512

abolishment of two functionally redundant mannosidases, MNS1 and MNS2, responsible for alpha-1,2-mannose trimming on the A and C branches of plant N-glycans lead to severe root growth inhibition under salt stress conditions in Arabidopsis

751608

malfunction

Homo sapiens

O60476, P33908, Q9UKM7

in triple KO (MAN1A1, MAN1A2, and MAN1B1) cells, Man9GlcNAc2 and Man8GlcNAc2 are the major N-glycan structures. Knockout of the MAN1A1 or MAN1A2 gene does not change the glycan profiles. Double KO cells (MAN1A1, MAN1A2) displayed increased high-mannose-type and decreased complex-type glycans. The N-glycan structures on recombinant proteins expressed in triple KO cells are simplified and changed from complex types to high-mannose types at the protein level

751118

metabolism

Homo sapiens

-

part of N-glycan pathway

704576

metabolism

Homo sapiens

Q9NR34

overexpression MAN1C1 shows anti-tumor effect by inducing apoptosis. MAN1C1 overexpression remarkably increases the ratio of Bax/Bcl-2 and inhibits epithelial-mesenchymal transition by increasing the expression of E-CA. In addition, the ratio of Bax/Bcl-2 and E-cadherin is increased in MAN1C1 gene overexpression renal cancer cells compared with the control cells

751168

metabolism

Homo sapiens

Q9UKM7

the enzyme catalyzes the first mannose trimming step in the processing of mammalian Asn-linked oligosaccharides

754053

metabolism

Candida albicans

Q8J0Q0

the enzyme is involved in the processing of N-linked mannans

754617

metabolism

Candida albicans ATCC 26555

-

the enzyme is involved in the processing of N-linked mannans

-

physiological function

Mus musculus

-

alpha-1,2-mannosidase function is not required for the suppressive capacity of regulatory T cells in vitro, but influences regulatory T cell adherence in vitro andmigration in vivo

706455

physiological function

Arabidopsis thaliana

-

either isozyme MANIa or MANIb can function as the Golgi alpha-mannosidase I that produces the Man5GlcNAc2 N-glycan structure necessary for complex N-glycan synthesis

703909

physiological function

Arabidopsis thaliana

Q8H116, Q9C512

in isoforms MNS1/MNS2 double mutant, MNS3 single mutant, accumulation of Man8GlcNAc2 is observed. A triple mutant lacking mannosidases MNS1, MNS2, and MNS3, EC 3.2.1.113, reveals the almost exclusive presence of Man9GlcNAc2 glycans. The MNS triple mutants display short, radially swollen roots and altered cell walls. Pharmacological inhibition of class I alpha-mannosidases in wild-type seedlings results in a similar root phenotype

751841

physiological function

Homo sapiens

P33908, Q9NR34

key enzyme in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1A1 represents an oncogene. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis

750718

physiological function

Homo sapiens

P33908, Q9NR34

key enzymes in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis

750718

physiological function

Arabidopsis thaliana

Q8H116, Q9C512

the enzyme is responsible for alpha-1,2-mannose trimming on the A and C branches of plant N-glycans. MNS1/MNS2-mediated mannose trimming of N-glycans is crucial in modulating glycoprotein abundance to withstand salt stress in plants

751608

physiological function

Penicillium citrinum

P31723

comparison of the molecular structure of the Penicillium citrinum Golgi enzyme, and yeast and human endoplasmic reticulum enzymes. There is a greater degree of freedom to bind the oligosaccharide in the active site of the fungal enzyme than in the yeast and human ER alpha1,2-mannosidases

754067

physiological function

Homo sapiens

-

enzyme is capable of rapidly cleaving the terminal mannose linkage of the alpha-1,6-alpha-1,6 branch in the absence of a terminal mannose in the alpha-1,6-alpha-1,3 branch. The enzyme hydrolyzes the alpha-l,2-mannose residues on the alpha-1,3 branch at a rate of approximately 80times faster than it hydrolyzes those on the alpha-1,6 branch

754220

physiological function

Arabidopsis thaliana

Q8H116, Q9C512

mutation results in Man(8)GlcNAc(2) accumulation in the Mns1 single mutant. In the Mns1/Mns2/Mns3 triple mutant, Man(9)GlcNAc(2) glycans are almost exclusively present. The Mns triple mutants display short, radially swollen roots and altered cell walls

751841

physiological function

Arabidopsis thaliana

Q8H116, Q9C512

mutation results in Man(8)GlcNAc(2) accumulation in the Mns2 single mutant. In the Mns1/Mns2/Mns3 triple mutant, Man(9)GlcNAc(2) glycans are almost exclusively present. The Mns triple mutants display short, radially swollen roots and altered cell walls

751841