3.2.1.111: 1,3-alpha-L-fucosidase
This is an abbreviated version!
For detailed information about 1,3-alpha-L-fucosidase, go to the full flat file.
Word Map on EC 3.2.1.111
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3.2.1.111
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transfucosylation
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oligosaccharides
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lacto-n-tetraose
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fucosylated
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perfringens
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3.2.1.51
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lacto-n-fucopentaose
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milk
-
glycoside
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glycomics
-
infant
-
3-fucosyllactose
- 3.2.1.111
-
transfucosylation
- oligosaccharides
- lacto-n-tetraose
-
fucosylated
- perfringens
-
3.2.1.51
- lacto-n-fucopentaose
- milk
- glycoside
-
glycomics
- infant
- 3-fucosyllactose
Reaction
Synonyms
AfcB, almond emulsin fucosidase I, alpha(1,3/4)-transfucosidase, alpha-1,3/4-L-fucosidase, alpha-L-fucosidase I, alphafuc, BbAfcB, cFase I, core fucosidase I, CpAfc2, fucosidase, 1,3-alpha-L-
ECTree
3.2.1.111 1,3-alpha-L-fucosidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.2.1.111 - 1,3-alpha-L-fucosidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-fucosyllactose + H2O
D-fucose + D-Gal-beta-(1->4)-D-Glc
-
-
-
?
asialoorosomucoid + H2O
?
-
specifically hydrolyzes fucose in alpha-1,3-linkage to N-acetylglucosamine of Asn-linked oligosaccharide chain branches
-
-
?
L-Fuc-alpha-(1->2)-D-Gal-beta-(1->3)-[L-Fuc-alpha-(1->4)]-GlcNAc + H2O
L-fucose + L-Fuc-alpha-(1->2)-D-Gal-beta-(1->3)-D-GlcNAc
-
i.e. Lewis b tetrasaccharide, 14% of the activity with 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->2)-D-Gal-beta-(1->4)-[L-Fuc-alpha-(1->3)]-D-GlcNAc + H2O
L-fucose + L-Fuc-alpha-(1->2)-D-Gal-beta-(1->4)-D-GlcNAc
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i.e. Lewis y tetrasaccharide, 128% of the activity with 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->3)-[D-Gal-beta-(1->4)]-D-Glc + H2O
L-fucose + D-Gal-beta-(1->4)-D-Glc
-
i.e. 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->3)-[D-Gal-beta-(1->4)]-D-GlcNAc + H2O
L-fucose + D-Gal-beta-(1->4)-D-GlcNAc
-
i.e. Lewis a trisaccharide, 160% of the activity with 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->3)-[D-Gal-beta-(1->4)]-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc + H2O
L-fucose + D-Gal-beta-(1->4)-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc
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i.e. lacto-N-fucopentaose III, 159% of the activity with 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->4)-D-Gal-beta-(1->3)-D-GlcNAc-beta-(1->3)-D-Gal-beta-(1->4)-D-Glc + H2O
L-fucose +
-
i.e. lacto-N-fucopentaose II, 186% of the activity with 3-fucosyllactose
-
-
?
L-Fuc-alpha-(1->4)-[D-Gal-beta-(1->3)]-D-GlcNAc + H2O
L-fucose + D-Gal-beta-(1->3)-D-GlcNAc
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i.e. Lewis a trisaccharide, 166% of the activity with 3-fucosyllactose
-
-
?
lactoferrin + H2O
?
-
hydrolyzes only alpha-1,3-linkages between fucose and N-acetylglucosamine
-
-
?
Lewis X trisaccharide + H2O
?
-
15448.5% activity compared to 4-nitrophenyl alpha-L-fucoside
-
-
?
3-fucosyllactose + H2O
L-fucose + lactose
-
1328.6% activity compared to 4-nitrophenyl alpha-L-fucoside
-
-
?
3-fucosyllactose + H2O
L-fucose + lactose
-
1328.6% activity compared to 4-nitrophenyl alpha-L-fucoside
-
-
?
3-O-fucosyllactose + 2'-fucosyllactose
lactodifucotetraose + ?
-
-
-
?
3-O-fucosyllactose + 2'-fucosyllactose
lactodifucotetraose + ?
-
-
-
?
3-O-fucosyllactose + lacto-N-fucopentaose I
lacto-N-difucohexaose + lactose
-
-
-
?
3-O-fucosyllactose + lacto-N-fucopentaose I
lacto-N-difucohexaose + lactose
-
-
-
?
3-O-fucosyllactose + lacto-N-neotetraose
lacto-N-fucopentaose III + lactose
-
-
-
?
3-O-fucosyllactose + lacto-N-neotetraose
lacto-N-fucopentaose III + lactose
-
-
-
?
3-O-fucosyllactose + lacto-N-tetraose
lacto-N-fucopentaose-II + lactose
-
-
-
?
3-O-fucosyllactose + lacto-N-tetraose
lacto-N-fucopentaose-II + lactose
-
-
-
?
4-nitrophenyl alpha-L-fucoside + H2O
4-nitrophenol + L-fucose
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100% activity
-
-
?
4-nitrophenyl alpha-L-fucoside + H2O
4-nitrophenol + L-fucose
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100% activity
-
-
?
4-nitrophenyl fucoside + H2O
4-nitrophenol + L-fucose
-
-
-
-
?
4-nitrophenyl fucoside + H2O
4-nitrophenol + L-fucose
-
-
-
-
?
horseradish type VI horseradish peroxidase + H2O
?
-
-
-
-
?
lacto-N-fucopentaitol + H2O
?
-
lacto-N-fucopentaitol II or III, no substrate: lacto-N-fucopentaitol I
-
-
?
additional information
?
-
-
Bifidobacteria are predominant bacteria present in the intestines of breast-fed infants and offer important health benefits for the host. alpha-L-Fucosidase AfcB play essential roles in degrading alpha1,3/4-fucosylated milk oligosaccharides, respectively, and also glycoconjugates, in the gastrointestinal tracts
-
-
?
additional information
?
-
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enzyme specifically releases alpha-1,3- and alpha-1,4-linked fucosyl residues from 3-fucosyllactose, various Lewis blood group substances, and lacto-N-fucopentaose II and III. The enzyme does not act on glycoconjugates containing alpha-1,2-fucosyl residue or on synthetic alpha-fucoside, i.e. p-nitrophenyl-alpha-L-fucoside
-
-
?
additional information
?
-
the enzyme can catalyse formation of the human milk oligosaccharide lacto-N-fucopentaose II through regioselective transfucosylation of lacto-N-tetraose with 3-fucosyllactose as donor substrate
-
-
?
additional information
?
-
-
the enzyme can catalyse formation of the human milk oligosaccharide lacto-N-fucopentaose II through regioselective transfucosylation of lacto-N-tetraose with 3-fucosyllactose as donor substrate
-
-
?
additional information
?
-
the enzyme can catalyse formation of the human milk oligosaccharide lacto-N-fucopentaose II through regioselective transfucosylation of lacto-N-tetraose with 3-fucosyllactose as donor substrate
-
-
?
additional information
?
-
-
the enzyme can catalyse formation of the human milk oligosaccharide lacto-N-fucopentaose II through regioselective transfucosylation of lacto-N-tetraose with 3-fucosyllactose as donor substrate
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl beta-L-fucoside, 4-nitrophenyl beta-D-fucoside, 4-nitrophenyl beta-D-glucoside, 4-nitrophenyl alpha-D-glucoside, 4-nitrophenyl alpha-D-galactoside, 4-nitrophenyl beta-D-galactoside, 4-nitrophenyl beta-D-lactoside, 4-nitrophenyl beta-D-xyloside, 4-nitrophenyl alpha-D-xyloside, 4-nitrophenyl beta-D-mannoside, 4-nitrophenyl alpha-D-mannoside, 4-nitrophenyl alpha-D-N-acetyl-glucoside, 4-nitrophenyl beta-D-N-acetyl-glucoside, 4-nitrophenyl alpha-D-N-acetyl-galactoside, 4-nitrophenyl beta-D-N-acetyl-galactoside, and 4-nitrophenyl alpha-D-N-acetyl-neuraminide. The enzyme is also inactive against 2'-fucsoyllactose, 6-fucosyl-N-acetylglucosamine, 6-fucosyl-N,N'-diacetylchitobiose, and Lewis A trisaccharide
-
-
?
additional information
?
-
-
no activity with 4-nitrophenyl beta-L-fucoside, 4-nitrophenyl beta-D-fucoside, 4-nitrophenyl beta-D-glucoside, 4-nitrophenyl alpha-D-glucoside, 4-nitrophenyl alpha-D-galactoside, 4-nitrophenyl beta-D-galactoside, 4-nitrophenyl beta-D-lactoside, 4-nitrophenyl beta-D-xyloside, 4-nitrophenyl alpha-D-xyloside, 4-nitrophenyl beta-D-mannoside, 4-nitrophenyl alpha-D-mannoside, 4-nitrophenyl alpha-D-N-acetyl-glucoside, 4-nitrophenyl beta-D-N-acetyl-glucoside, 4-nitrophenyl alpha-D-N-acetyl-galactoside, 4-nitrophenyl beta-D-N-acetyl-galactoside, and 4-nitrophenyl alpha-D-N-acetyl-neuraminide. The enzyme is also inactive against 2'-fucsoyllactose, 6-fucosyl-N-acetylglucosamine, 6-fucosyl-N,N'-diacetylchitobiose, and Lewis A trisaccharide
-
-
?
additional information
?
-
-
no hydrolysis of fucose alpha-1,6 or alpha-1,2-linkages to N-acetylglucosamine, as in IgG glycopeptides or 2'-fucosyllactitol
-
-
?
additional information
?
-
-
no substrates are alpha2-macroglobulin (MW 72600), bovine IgG glycopeptides or milk oligosaccharide 2'-fucosyllactose
-
-
?
additional information
?
-
-
the enzyme hydrolyzes fucose alpha-1,3 or alpha-1,4-linkages to N-acteylglucosamine
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-
?
additional information
?
-
-
the enzyme hydrolyzes fucose alpha-1,3 or alpha-1,4-linkages to N-acteylglucosamine
-
-
?
