3.2.1.106: mannosyl-oligosaccharide glucosidase
This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide glucosidase, go to the full flat file.
Word Map on EC 3.2.1.106
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3.2.1.106
-
pompe
-
lysosomal
-
glycogen
-
infantile
-
n-linked
-
late-onset
-
cardiac
-
maltase
-
cardiomyopathy
-
mannose
-
myopathy
-
glycogenosis
-
castanospermine
-
infantile-onset
-
neuromuscular
-
mannosidase
-
alglucosidase
-
gsdii
-
ventilation
-
asparagine-linked
-
3.2.1.20
-
n-glycans
-
mannose-6-phosphate
-
high-mannose
-
glucosidases
-
1-deoxynojirimycin
-
swainsonine
-
acarbose
-
lipid-linked
-
limb-girdle
-
n-butyldeoxynojirimycin
-
isomaltose
-
analysis
-
cardiomegaly
-
endoglucosaminidase
-
deoxymannojirimycin
-
turanose
-
glycogen-storage
-
ventilator-free
-
alpha-glucoside
-
pharmacology
-
medicine
-
cardiorespiratory
-
ci-mpr
-
n-glycoproteins
-
pseudodeficiency
-
cation-independent
-
amyloglucosidase
- 3.2.1.106
- pompe
- lysosomal
- glycogen
-
infantile
-
n-linked
-
late-onset
- cardiac
- maltase
- cardiomyopathy
- mannose
- myopathy
- glycogenosis
- castanospermine
-
infantile-onset
- neuromuscular
-
mannosidase
-
alglucosidase
-
gsdii
-
ventilation
-
asparagine-linked
-
3.2.1.20
- n-glycans
- mannose-6-phosphate
-
high-mannose
- glucosidases
- 1-deoxynojirimycin
- swainsonine
- acarbose
-
lipid-linked
-
limb-girdle
- n-butyldeoxynojirimycin
- isomaltose
- analysis
- cardiomegaly
-
endoglucosaminidase
- deoxymannojirimycin
- turanose
-
glycogen-storage
-
ventilator-free
- alpha-glucoside
- pharmacology
- medicine
-
cardiorespiratory
-
ci-mpr
- n-glycoproteins
-
pseudodeficiency
-
cation-independent
- amyloglucosidase
Reaction
Synonyms
(Glc3)-glucosidase, acid alpha-glucosidase, alpha-glucosidase I, CHO-GAA, CWH41, Cwh41p, GAA, GCSI, Glc I, Glc3 oligosaccharide glucosidase, Glc3-glucosidase, Glc3-oligosaccharide glucosidase, Glc3-OS-glucosidase, Glc3Man9GlcNAc2 oligosaccharide glucosidase, Glc3Man9NAc2 oligosaccharide glucosidase, glucosidase 1, glucosidase I, glucosidase, mannosyloligosaccharide, glucosidase-1, glycoengineered acid alpha-glucosidase, HP-GAA, K12 YgjK protein, KNOPF, mannosyl-oligosaccharide glucosidase, mannosylglycerate hydrolase, MOGS, oxime-neo-rhGAA, PGI, processing alpha-glucosidase I, processing exoglucosidase I, processing glucosidase I, rhGAA, tgGAA, trimming enzyme I, trimming glucosidase I, Tt8MGH, YgjK
ECTree
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Reference on EC 3.2.1.106 - mannosyl-oligosaccharide glucosidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grinna, L.S.; Robbins, P.W.
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins
J. Biol. Chem.
255
2255-2258
1980
Rattus norvegicus
Bause E.; Erkens, R.; Schweden, J.; Jaenicke, L.
Purification and characterization of trimming glucosidase I from Saccharomyces cerevisiae
FEBS Lett.
206
208-212
1986
Bos taurus, Saccharomyces cerevisiae
-
Kilker, R.D.Jr.; Saunier, B.; Tkacz, J.S.; Herscovics, A.
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2
J. Biol. Chem.
256
5299-5303
1981
Saccharomyces cerevisiae, Saccharomyces cerevisiae X-2180
Hettkamp, H.; Legler, G.; Bause, E.
Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides
Eur. J. Biochem.
142
85-90
1984
Bos taurus
Grinna, L.S.; Robbins, P.W.
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides
J. Biol. Chem.
254
8814-8818
1979
Rattus norvegicus
Michael, J.M.; Kornfeld, S.
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides
Arch. Biochem. Biophys.
199
249-258
1980
Bos taurus
Zamarripa-Morales, S.; Villagomez-Castro, J.C.; Calvo-Mendez, C.; Flores-Carreon, A.; Lopez-Romero, E.
Entamoeba histolytica: identification and properties of membrane-bound and soluble alpha-glucosidases
Exp. Parasitol.
93
109-115
1999
Entamoeba histolytica, Entamoeba histolytica HM1:IMSS
Herscovics, A.
Importance of glycosidases in mammalian glycoprotein biosynthesis
Biochim. Biophys. Acta
1473
96-107
1999
Homo sapiens, Mammalia
Herscovics, A.
Processing glycosidases of Saccharomyces cerevisiae
Biochim. Biophys. Acta
1426
275-285
1999
Saccharomyces cerevisiae, Mammalia
Palcic, M.M.; Scaman, C.H.; Otter, A.; Szpacenko, A.; Romaniouk, A.; Li, Y.X.; Vijay, I.K.
Processing alpha-glucosidase I is an inverting glycosidase
Glycoconj. J.
16
351-355
1999
Bos taurus, Saccharomyces cerevisiae
Rush, J.S.; Waechter, C.J.
Topological studies on the enzymes catalyzing the biosynthesis of Glc-P-dolichol and the triglucosyl cap of Glc3Man9GlcNAc2-P-P-dolichol in microsomal vesicles from pig brain: use of the processing glucosidases I/II as latency markers
Glycobiology
8
1207-1213
1998
Rattus norvegicus, Sus scrofa
Kosuge, T.; Tamura, T.; Nariuchi, H.; Toyoshima, S.
Effect of inhibitors of glycopotein processing on cytokine secretion and production in anti CD3-stimulated T cells
Biol. Pharm. Bull.
23
1-5
2000
Mus musculus, Mus musculus C57BL/6
Elting, J.J.; Chen, W.W.; Lennarz, W.J.
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains
J. Biol. Chem.
255
2325-2331
1980
Gallus gallus
Szumilo, T.; Kaushal, G.P.; Elbein, A.D.
Purification and properties of glucosidase I from mung bean seedlings
Arch. Biochem. Biophys.
247
261-271
1986
Vigna radiata
Hettkamp, H.; Bause, E.; Legler, G.
Inhibition by nojirimycin and 1-deoxynojirimycin of microsomal glucosidases from calf liver acting on the glycoprotein oligosaccharides Glc1-3Man9GlcNAc2
Biosci. Rep.
2
899-906
1982
Bos taurus
Liu, T.; Stetson, B.; Turco, S.J.; Hubbard, S.C.; Robbins, P.W.
Arrangement of glucose residues in the lipid-linked oligosaccharide precursor of asparaginyl oligosaccharides
J. Biol. Chem.
254
4554-4559
1979
Talaromyces funiculosus, Rattus norvegicus, Talaromyces funiculosus QM474
Kalz-Fuller, B.; Bieberich, E.; Bause, E.
Cloning and expression of glucosidase I from human hippocampus
Eur. J. Biochem.
231
344-351
1995
Homo sapiens, Sus scrofa
Kalz-Fuller, B.; Heidrich-Kaul, C.; Nöthen, M; Bause, E.; Schwanitz, G.
Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids
Genomics
34
442-443
1996
Homo sapiens
Simons, J.F.; Ebersold, M.; Helenius, A.
Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p
EMBO J.
17
396-405
1998
Saccharomyces cerevisiae
Romero, P.A.; Dijkgraaf, G.J.P.; Shahinian, S.; Herscovics, A.; Bussey, H.
The yeast CWH41 gene encodes glucosidase I
Glycobiology
7
997-1004
1997
Saccharomyces cerevisiae
Jiang, B.; Sheraton, J.; Ram, A.F.J.; Dijkgraaf, G.J.P.; Klis, F.M.; Bussey, H.
CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in beta1,6-glucan assembly
J. Bacteriol.
178
1162-1171
1996
Saccharomyces cerevisiae
Shailubhai, K.; Pratta, M.A.; Vijay, I.K.
Purification and characterization of glucosidase I involved in N-linked glycoprotein processing in bovine mammary gland
Biochem. J.
247
555-562
1987
Bos taurus, Cavia porcellus, Mus musculus, Rattus norvegicus
Shailubhai, K.; Pukazhenthi, B.S.; Saxena, E.S.; Varma, G.M.; Vijay, I.K.
Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain
J. Biol. Chem.
266
16587-16593
1991
Rattus norvegicus
Bause, E.; Schweden, J.; Gross, A.; Orthen, B.
Purification and characterization of trimming glucosidase I from pig liver
Eur. J. Biochem.
183
661-669
1989
Bos taurus, Homo sapiens, Sus scrofa
Schweden, J.; Borgmann, C.; Legler, G.; Bause, E.
Characterization of calf liver glucosidase I and its inhibition by basic sugar analogs
Arch. Biochem. Biophys.
248
335-340
1986
Bos taurus
Boisson, M.; Gomord, V.; Audran, C.; Berger, N.; Dubreucq, B.; Granier, F.; Lerouge, P.; Faye, L.; Caboche, M.; Lepiniec, L.
Arabidopsis glucosidase I mutants reveal a critical role of N-glycan trimming in seed development
EMBO J.
20
1010-1019
2001
Arabidopsis thaliana
Dhanawansa, R.; Faridmoayer, A.; Van der Merwe, G.; Li, Y.X.; Scaman, C.H.
Overexpression, purification, and partial characterization of Saccharomyces cerevisiae processing alpha glucosidase I
Glycobiology
12
229-234
2002
Saccharomyces cerevisiae, Saccharomyces cerevisiae AH22
Hakamata, W.; Muroi, M.; Nishio, T.; Oku, T.; Takatsuki, A.
Recognition properties of processing alpha-glucosidase I and alpha-glucosidase II
J. Carbohydr. Chem.
23
27-39
2004
Rattus norvegicus
-
Gillmor, C.S.; Poindexter, P.; Lorieau, J.; Palcic, M.M.; Somerville, C.
Alpha-glucosidase I is required for cellulose biosynthesis and morphogenesis in Arabidopsis
J. Cell. Biol.
156
1003-1013
2002
Arabidopsis thaliana (F4HTM3)
Faridmoayer, A.; Scaman, C.H.
An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41
Protein Expr. Purif.
33
11-18
2004
Saccharomyces cerevisiae
Tonozuka, T.; Uechi, A.; Mizuno, M.; Ichikawa, K.; Nishikawa, A.; Sakano, Y.
Crystallization and preliminary X-ray analysis of Escherichia coli K12 YgjK protein, a member of glycosyl hydrolase family 63
Acta Crystallogr. Sect. D
60
1284-1285
2004
Escherichia coli
Faridmoayer, A.; Scaman, C.H.
Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I
Glycoconj. J.
24
429-437
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae AH22
Ruddock, L.W.; Molinari, M.
N-glycan processing in ER quality control
J. Cell Sci.
119
4373-4380
2006
Homo sapiens, Mus musculus
Saint-Jore-Dupas, C.; Nebenfuehr, A.; Boulaflous, A.; Follet-Gueye, M.L.; Plasson, C.; Hawes, C.; Driouich, A.; Faye, L.; Gomord, V.
Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway
Plant Cell
18
3182-3200
2006
Arabidopsis thaliana
McVie-Wylie, A.J.; Lee, K.L.; Qiu, H.; Jin, X.; Do, H.; Gotschall, R.; Thurberg, B.L.; Rogers, C.; Raben, N.; OCallaghan, M.; Canfield, W.; Andrews, L.; McPherson, J.M.; Mattaliano, R.J.
Biochemical and pharmacological characterization of different recombinant acid alpha-glucosidase preparations evaluated for the treatment of Pompe disease
Mol. Genet. Metab.
94
448-455
2008
Cricetulus griseus
Kurakata, Y.; Uechi, A.; Yoshida, H.; Kamitori, S.; Sakano, Y.; Nishikawa, A.; Tonozuka, T.
Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63
J. Mol. Biol.
381
116-128
2008
Escherichia coli
Zhu, Y.; Jiang, J.L.; Gumlaw, N.K.; Zhang, J.; Bercury, S.D.; Ziegler, R.J.; Lee, K.; Kudo, M.; Canfield, W.M.; Edmunds, T.; Jiang, C.; Mattaliano, R.J.; Cheng, S.H.
Glycoengineered Acid alpha-Glucosidase With Improved Efficacy at Correcting the Metabolic Aberrations and Motor Function Deficits in a Mouse Model of Pompe Disease
Mol. Ther.
17
954-963
2009
Homo sapiens
Chang, J.; Wang, L.; Ma, D.; Qu, X.; Guo, H.; Xu, X.; Mason, P.M.; Bourne, N.; Moriarty, R.; Gu, B.; Guo, J.T.; Block, T.M.
Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses
Antimicrob. Agents Chemother.
53
1501-1508
2009
Bovine viral diarrhea virus 1, Dengue virus, West Nile virus
Frade-Perez, M.D.; Hernandez-Cervantes, A.; Flores-Carreon, A.; Mora-Montes, H.M.
Biochemical characterization of Candida albicans alpha-glucosidase I heterologously expressed in Escherichia coli
Antonie van Leeuwenhoek
98
291-298
2010
Candida albicans (Q2V621), Candida albicans
Boulaflous, A.; Saint-Jore-Dupas, C.; Herranz-Gordo, M.; Pagny-Salehabadi, S.; Plasson, C.; Garidou, F.; Kiefer-Meyer, M.; Ritzenthaler, C.; Faye, L.; Gomord, V.
Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER
BMC Plant Biol.
9
144
2009
Arabidopsis thaliana (F4HTM3)
Rawlings, A.; Lomas, H.; Pilling, A.; Lee, M.; Alonzi, D.; Rountree, J.; Jenkinson, S.; Fleet, G.; Dwek, R.; Jones, J.; Butters, T.
Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin glucosidase inhibitors
ChemBioChem
10
1101-1105
2009
Rattus norvegicus
Miyazaki, T.; Matsumoto, Y.; Matsuda, K.; Kurakata, Y.; Matsuo, I.; Ito, Y.; Nishikawa, A.; Tonozuka, T.
Heterologous expression and characterization of processing alpha-glucosidase I from Aspergillus brasiliensis ATCC 9642
Glycoconj. J.
28
563-571
2011
Aspergillus brasiliensis (G1UJA9), Aspergillus brasiliensis ATCC 9642 (G1UJA9)
Sadat, M.A.; Moir, S.; Chun, T.W.; Lusso, P.; Kaplan, G.; Wolfe, L.; Memoli, M.J.; He, M.; Vega, H.; Kim, L.J.; Huang, Y.; Hussein, N.; Nievas, E.; Mitchell, R.; Garofalo, M.; Louie, A.; Ireland, D.C.; Grunes, C.; Cimbro, R.; Patel, V.; Holzapfel, G.; Salahuddin, D.; Bristol, T.; Adams, D.; Marciano, B.E.
Glycosylation, hypogammaglobulinemia, and resistance to viral infections
N. Engl. J. Med.
370
1615-1625
2014
Homo sapiens
Wang, S.; Xu, Y.; Li, Z.; Zhang, S.; Lim, J.M.; Lee, K.O.; Li, C.; Qian, Q.; Jiang, d.e..A.; Qi, Y.
OsMOGS is required for N-glycan formation and auxin-mediated root development in rice (Oryza sativa L.)
Plant J.
78
632-645
2014
Oryza sativa
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