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3.2.1.106: mannosyl-oligosaccharide glucosidase

This is an abbreviated version!
For detailed information about mannosyl-oligosaccharide glucosidase, go to the full flat file.

Word Map on EC 3.2.1.106

Reaction

Glc3Man9GlcNAc2-[protein]
+
H2O
=
Glc2Man9GlcNAc2-[protein]
 +
beta-D-glucopyranose

Synonyms

(Glc3)-glucosidase, acid alpha-glucosidase, alpha-glucosidase I, CHO-GAA, CWH41, Cwh41p, GAA, GCSI, Glc I, Glc3 oligosaccharide glucosidase, Glc3-glucosidase, Glc3-oligosaccharide glucosidase, Glc3-OS-glucosidase, Glc3Man9GlcNAc2 oligosaccharide glucosidase, Glc3Man9NAc2 oligosaccharide glucosidase, glucosidase 1, glucosidase I, glucosidase, mannosyloligosaccharide, glucosidase-1, glycoengineered acid alpha-glucosidase, HP-GAA, K12 YgjK protein, KNOPF, mannosyl-oligosaccharide glucosidase, mannosylglycerate hydrolase, MOGS, oxime-neo-rhGAA, PGI, processing alpha-glucosidase I, processing exoglucosidase I, processing glucosidase I, rhGAA, tgGAA, trimming enzyme I, trimming glucosidase I, Tt8MGH, YgjK

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.106 mannosyl-oligosaccharide glucosidase

Inhibitors

Inhibitors on EC 3.2.1.106 - mannosyl-oligosaccharide glucosidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-deoxymannojirimycin
-
very slight inhibition, Ki = 0.19 mM
1-deoxynojirimycin
2,5-Dihydroxymethyl-3,4-dihydroxypyrrolidine
-
plant pyrrolidine alkaloid, DMDP, 0.04 mM: 50% inhibition
2,6-anhydro-1-benzamide-D-glycero-D-ido-heptitol
-
18.2% inhibition at 1 mM
4-nitrophenyl-2-deoxy-alpha-D-glucopyranoside
-
56.2% inhibition at 5 mM
4-nitrophenyl-3-deoxy-alpha-D-glucopyranoside
-
71.7% inhibition at 5 mM
4-nitrophenyl-4-deoxy-alpha-D-glucopyranoside
-
18.5% inhibition at 5 mM
4-nitrophenyl-5-deoxy-alpha-D-glucopyranoside
-
22.2% inhibition at 5 mM
4-nitrophenyl-6-deoxy-alpha-D-glucopyranoside
-
32.3% inhibition at 5 mM
Ag+
-
potent inhibitor, inhibition reversed by adding an excess of dithiothreitol
australine
39% inhibition at 0.02 mM
bromoconduritol
22% inhibition at 0.02 mM
castanospermine
chloride
-
inhibitory above 0.3 M, 0.5 M: 30% inhibition
CM-9-78
D-glucose
D-mannose
deoxynojirimycin
-
-
diethyl dicarbonate
-
55% inhibition at 1 mM after 30 min
ethanolamine
-
-
ethyl-3-(3-(dimethylamino)propyl)carbodiimide
-
90% inhibition at 50 mM after 60 min at pH 6.8, 4°C, preincubation with deoxynorjirmycin prevents
glycerol
-
2% or higher: 25% or more inhibition
heavy-metal ions
-
potent inhibitors, inhibition reversed by adding an excess of dithiothreitol
-
Hg2+
-
potent inhibitor, inhibition reversed by adding an excess of dithiothreitol
kojibiose
Man9GlcNAc
-
1 mM thyroglobulin-derived Man9GlcNAc: 22% inhibition
Mg2+
-
slight inhibition
Mn2+
-
slight inhibition
N,N-dimethyl-1-deoxynojirimycin
N-(5-carboxypentyl)-1-deoxynojirimycin
N-(6'-(2'',4''-dinitrophenylamino)hexyl)-1-deoxynojirimycin
-
-
N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin
-
highly potent inhibitor of alpha-glucosidase I
N-5-carboxypentyl-1-deoxymannojirimycin
-
very slight inhibition, Ki = 0.1 mM
N-butyl-1-deoxynojirimycin
-
strong inhibition, Ki = 0.00009 mM
N-butyl-deoxynojirimycin
N-butyldeoxynojirimycin
-
-
N-decanoyl-1-deoxynojirimycin
-
very slight inhibition, Ki = 0.07 mM
N-decyl-1-deoxynojirimycin
-
strong inhibition, Ki = 0.0004 mM
N-dodecyl-1-deoxynojirimycin
-
slight inhibition
N-ethylmaleimide
N-hexyl-1-deoxynojirimycin
-
strong inhibition, Ki = 0.00013 mM
N-methyl-1-deoxymannojirimycin
-
very slight inhibition, Ki = 0.017 mM
N-methyl-1-deoxynojirimycin
N-nonyl-deoxynojirimycin
Nojirimycin
octyl-beta-glucoside
OSL-95II
p-Aminophenyl-beta-thioglucoside
-
100 mM: 73% inhibition
p-nitrophenyl-alpha-D-glucoside
p-nitrophenyl-beta-D-glucoside
PBDNJ0801
PBDNJ0803
PBDNJ0804
phosphate
-
inhibitory above 0.3 M, 0.5 M: 30% inhibition
SDS
-
strong inhibition
sulfate
-
0.1-0.2 M: 15-20% inhibition, somewhate more inhibitory at higher concentrations
tricine
-
-
Tris/maleate
-
10 mM: 60% inhibition
Trypsin
-
up to 40% inhibition in the presence of Lubrol PX, without Lubrol PX: no inhibition
-
additional information
-