3.11.1.3: phosphonopyruvate hydrolase

This is an abbreviated version!
For detailed information about phosphonopyruvate hydrolase, go to the full flat file.

Reaction

Synonyms

PalA, PPH

ECTree

3 Hydrolases

3.11 Acting on carbon-phosphorus bonds

3.11.1 Acting on carbon-phosphorus bonds (only sub-subclass identified to date)

3.11.1.3 phosphonopyruvate hydrolase

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Results	in table
1	Activating Compound
100	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Stability
19	Inhibitors
4	Ki Value [mM]
3	KM Value [mM]
12	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
2	Pathway
2	pH Optimum
1	pI Value
2	Protein Variants
2	Purification (Commentary)
1	Reaction
8	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
4	Storage Stability
12	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.11.1.3 - phosphonopyruvate hydrolase

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3-phosphonopropionic acid

2 entries

Aminomethylphosphonic acid

Burkholderia cepacia

10 mM, 19% inhibition

Ca2+

competitive

Cu2+

5 mM, 41% loss of activity

EDTA

Fe2+

5 mM, 94% inhibition

glyphosate

10 mM, 23% inhibition

667335

hydroxymethylphosphonic acid

Variovorax sp.

Q84G06

5 mM, 25% loss of activity

Mn2+

oxalate

competitive

phosphoenolpyruvate

competitive

Phosphonoacetate

10 mM, 30% inhibition

667335

phosphonobutyric acid

Burkholderia cepacia

10 mM, 14% inhibition

667335

Phosphonoformate

Burkholderia cepacia

10 mM, 37% inhibition

667335

Phosphonoformic acid

Variovorax sp.

Q84G06

5 mM, 76% loss of activity

sulfopyruvate

competitive