3.11.1.1: phosphonoacetaldehyde hydrolase

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For detailed information about phosphonoacetaldehyde hydrolase, go to the full flat file.

Reaction

Synonyms

2-phosphonoacetaldehyde phosphonohydrolase, 2-phosphonoacetylaldehyde phosphonohydrolase, hydrolase, phosphonoacetylaldehyde, P-Ald hydrolase, phosphonatase

ECTree

     3 Hydrolases

         3.11 Acting on carbon-phosphorus bonds

             3.11.1 Acting on carbon-phosphorus bonds (only sub-subclass identified to date)

                3.11.1.1 phosphonoacetaldehyde hydrolase

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Results	in table
3	Activating Compound
4988	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
4	Crystallization (Commentary)
20	General Information
2	General Stability
17	Inhibitors
2	Ki Value [mM]
22	KM Value [mM]
10	Metals/Ions
2	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
35	Organism
4	Pathway
4	PDB ID
5	pH Optimum
1	pH Range
2	pH Stability
23	Protein Variants
2	Purification (Commentary)
14	Reaction
4	Reaction Type
31	Reference
1	Renatured (Commentary)
7	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
32	Substrates and Products (Substrate)
1	Subunits
17	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
25	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 3.11.1.1 - phosphonoacetaldehyde hydrolase

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SYSTEMATIC NAME

IUBMB Comments

2-oxoethylphosphonate phosphonohydrolase

This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. The mechanism is similar to that used by EC 4.1.2.13, fructose-bisphosphate aldolase, to break a C-C bond. Belongs to the haloacetate dehalogenase family.