3.11.1.1: phosphonoacetaldehyde hydrolase
This is an abbreviated version!
For detailed information about phosphonoacetaldehyde hydrolase, go to the full flat file.
Word Map on EC 3.11.1.1
-
3.11.1.1
-
phosphorus
-
phosphonates
-
carbon-phosphorus
-
dehalogenase
-
phosphonoacetate
-
2-aminoethylphosphonate
-
schiff-base
-
organophosphonate
-
phosphonopyruvate
-
phosphomutase
- 3.11.1.1
- phosphorus
- phosphonates
-
carbon-phosphorus
-
dehalogenase
- phosphonoacetate
- 2-aminoethylphosphonate
-
schiff-base
-
organophosphonate
- phosphonopyruvate
-
phosphomutase
Reaction
Synonyms
2-phosphonoacetaldehyde phosphonohydrolase, 2-phosphonoacetylaldehyde phosphonohydrolase, hydrolase, phosphonoacetylaldehyde, P-Ald hydrolase, phosphonatase
ECTree
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Reference on EC 3.11.1.1 - phosphonoacetaldehyde hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Olsen, D.B.; Hepburn, T.W.; Moos, M.; Mariano, P.S.; Dunaway-Mariano, D.
Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue
Biochemistry
27
2229-2234
1988
Bacillus cereus
La Nauze, J.M.; Coggins, J.R.; Dixon, H.B.F.
Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase
Biochem. J.
165
409-411
1977
Bacillus cereus
La Nauze, J.M.; Rosenberg, H.; Shaw, D.C.
The enzyme cleavage of the carbon-phosphorous bond: purification and properties of phosphonatase
Biochim. Biophys. Acta
212
332-350
1970
Bacillus cereus
Lee, S.L.; Hepburn, T.W.; Swartz, W.H.; Ammon, H.L.; Mariano, P.S.; Dunaway-Mariano, D.
Stereochemical probe for the mechanism of P-C bond cleavage catalyzed by the Bacillus cereus phosphonoacetaldehyde hydrolase
J. Am. Chem. Soc.
114
7346-7354
1992
Bacillus cereus
-
Dumora, C.; Marche, M.; Doignon, F.; Aigle, M.; Cassaigne, A.; Crouzet, M.
First characterization of the phosphonoacetaldehyde hydrolase gene of Pseudomonas aeruginosa
Gene
197
405-412
1997
Pseudomonas aeruginosa, Pseudomonas aeruginosa A237
Baker, A.S.; Ciocci, M.J.; Metcalf, W.W.; Kim, J.; Babbitt, P.C.; Wanner, B.L.; Martin, B.M.; Dunaway-Mariano, D.
Insight into the mechanism of catalysis by the P-C cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis
Biochemistry
37
9305-9315
1998
Bacillus cereus, Salmonella enterica subsp. enterica serovar Typhimurium
Olsen, D.B.; Hepburn, T.W.; Lee, S.l.; Martin, B.M.; Mariano, P.S.; Dunaway-Mariano, D.
Investigation of the substrate binding and catalytic groups of the P-C bond cleaving enzyme, phosphonoacetaldehyde hydrolase
Arch. Biochem. Biophys.
296
144-151
1992
Bacillus cereus, Bacillus cereus AI-2
Morais, M.C.; Zhang, W.; Baker, A.S.; Zhang, G.; Dunaway-Mariano, D.; Allen, K.N.
The crystal structure of Bacillus cereus phosphonoacetaldehyde hydrolase insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily
Biochemistry
39
10385-10396
2000
Bacillus cereus
Zhang, G.; Mazurkie, A.S.; Dunaway-Mariano, D.; Allen, K.N.
Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis
Biochemistry
41
13370-13377
2002
Bacillus cereus (O31156), Bacillus cereus
Zhang, G.; Morais, M.C.; Dai, J.; Zhang, W.; Dunaway-Mariano, D.; Allen, K.N.
Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily
Biochemistry
43
4990-4997
2004
Bacillus cereus (O31156), Bacillus cereus
Morais, M.C.; Zhang, G.; Zhang, W.; Olsen, D.B.; Dunaway-Mariano, D.; Allen, K.N.
X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis
J. Biol. Chem.
279
9353-9361
2004
Bacillus cereus (O31156)
Dumora, C.; Lacoste, A.M.; Cassaigne, A.; Mazat, J.P.
Allosteric regulation of phosphonoacetaldehyde hydrolase by n-butylphosphonic acid
Biochem. J.
280
557-559
1991
Pseudomonas aeruginosa, Pseudomonas aeruginosa A237
Lahiri, S.D.; Zhang, G.; Dai, J.; Dunaway-Mariano, D.; Allen, K.N.
Analysis of the substrate specificity loop of the HAD superfamily cap domain
Biochemistry
43
2812-2820
2004
Bacillus cereus
Ternan, N.G.; Quinn, J.P.
Phosphate starvation-independent 2-aminoethylphosphonic acid biodegradation in a newly isolated strain of Pseudomonas putida, NG2
Syst. Appl. Microbiol.
21
346-352
1998
Klebsiella aerogenes, Pseudomonas putida, Pseudomonas putida NG2, Klebsiella aerogenes IFO 12010
Szefczyk, B.; Kedzierski, P.; Sokalski, W.A.; Leszczynski, J.
Theoretical insights into catalysis by phosphonoacetaldehyde hydrolase
Mol. Phys.
104
2203-2211
2006
Bacillus cereus
-
Szefczyk, B.
Towards understanding phosphonoacetaldehyde hydrolase: an alternative mechanism involving proton transfer that triggers P-C bond cleavage
Chem. Commun. (Camb. )
2008
4162-4164
2008
Bacillus cereus
Cooley, N.A.; Kulakova, A.N.; Villarreal-Chiu, J.F.; Gilbert, J.A.; McGrath, J.W.; Quinn, J.P.
Phosphonoacetate biosynthesis: in vitro detection of a novel NADP(+)-dependent phosphonoacetaldehyde-oxidizing activity in cell-extracts of the marine Roseovarius nubinhibens ISM
Microbiology
80
335-340
2011
Roseovarius nubinhibens
Klimek-Ochab, M.; Mucha, A.; Zymanczyk-Duda, E.
2-Aminoethylphosphonate utilization by the cold-adapted Geomyces pannorum P11 strain
Curr. Microbiol.
68
330-335
2014
Pseudogymnoascus pannorum (A0A093YC30), Pseudogymnoascus pannorum, Pseudogymnoascus pannorum VKM F-3808 (A0A093YC30)
Villarreal-Chiu, J.F.; Quinn, J.P.; McGrath, J.W.
The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment
Front. Microbiol.
3
19
2012
Klebsiella aerogenes, Salmonella enterica subsp. enterica serovar Typhimurium (Q7ZAP3), Pseudomonas putida (Q8RSQ3), Pseudomonas aeruginosa (Q9I433), Pseudomonas putida NG2 (Q8RSQ3)
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