3.10.1.1: N-sulfoglucosamine sulfohydrolase

This is an abbreviated version!
For detailed information about N-sulfoglucosamine sulfohydrolase, go to the full flat file.

Word Map on EC 3.10.1.1

3.10.1.1

mucopolysaccharidosis

lysosomal

sanfilippo

mps-iiia

naglu

n-sulfate

sulfate-derived

heparinum

medicine

oestrone

hgsnat

sumf1

iduronate

sulfatases

ubiquitin-positive

drug development

pharmacology

diagnostics

Reaction

Synonyms

2-desoxy-2-sulphamido-D-glucose sulphamidase, 2-desoxy-D-glucoside-2-sulphamate sulphohydrolase, heparan N-sulfatase, heparan-N-sulfatase, heparan-N-sulphatase, heparin sulfamidase, N-sulfoglucosamine sulfohydrolase, N-sulphoglucosamine, SGSH, sulfamate sulfohydrolase, sulfamidase, sulfoglucosamine sulfamidase, sulphamate sulphohydrolase, sulphamidase, sulphohydrolase

ECTree

3 Hydrolases

3.10 Acting on sulfur-nitrogen bonds

3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

3.10.1.1 N-sulfoglucosamine sulfohydrolase

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Results	in table
1	Activating Compound
69	AA Sequence
14	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
608	Disease/ Diagnostics
11	General Information
2	IC50 Value
10	Inhibitors
8	KM Value [mM]
9	Localization
2	Metals/Ions
14	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
181	Organism
4	Pathway
10	PDB ID
12	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
5	Posttranslational Modification
12	Protein Variants
11	Purification (Commentary)
2	Reaction
1	Reaction Type
42	Reference
27	Source Tissue
1	Storage Stability
40	Substrates and Products (Substrate)
6	Subunits
42	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

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Source Tissue on EC 3.10.1.1 - N-sulfoglucosamine sulfohydrolase

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highly vacuolated

primary, cultured

additional information

Mus musculus

sulphamidase activity is undetectable in liver, kidney, brain, and spleen from untreated mucopolysaccharidosis type IIIA mice, whereas levels of sulphamidase activity in the liver, kidney, and spleen of mucopolysaccharidosis type IIIA mice treated with the sulphamidase vector averaged 68%, 5%, and 186% of normal activity, respectively

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